******************************************************************************** MEME - Motif discovery tool ******************************************************************************** MEME version 4.9.1 (Release date: Fri Aug 23 16:49:42 2013 +1000) For further information on how to interpret these results or to get a copy of the MEME software please access http://meme.nbcr.net. This file may be used as input to the MAST algorithm for searching sequence databases for matches to groups of motifs. MAST is available for interactive use and downloading at http://meme.nbcr.net. ******************************************************************************** ******************************************************************************** REFERENCE ******************************************************************************** If you use this program in your research, please cite: Timothy L. Bailey and Charles Elkan, "Fitting a mixture model by expectation maximization to discover motifs in biopolymers", Proceedings of the Second International Conference on Intelligent Systems for Molecular Biology, pp. 28-36, AAAI Press, Menlo Park, California, 1994. ******************************************************************************** ******************************************************************************** TRAINING SET ******************************************************************************** DATAFILE= sequences ALPHABET= ACDEFGHIKLMNPQRSTVWY Sequence name Weight Length Sequence name Weight Length ------------- ------ ------ ------------- ------ ------ ABL1_HUMAN 1.0000 91 FYN_HUMAN 1.0000 98 HCK_HUMAN 1.0000 98 SHC1_HUMAN 1.0000 92 SRC_HUMAN 1.0000 98 TEC_HUMAN 1.0000 99 ******************************************************************************** ******************************************************************************** COMMAND LINE SUMMARY ******************************************************************************** This information can also be useful in the event you wish to report a problem with the MEME software. command: meme sequences -protein -oc . -nostatus -time 18000 -maxsize 60000 -mod oops -nmotifs 3 -minw 6 -maxw 50 -minsites 6 -maxsites 6 model: mod= oops nmotifs= 3 evt= inf object function= E-value of product of p-values width: minw= 6 maxw= 50 minic= 0.00 width: wg= 11 ws= 1 endgaps= yes nsites: minsites= 6 maxsites= 6 wnsites= 0.8 theta: prob= 1 spmap= pam spfuzz= 120 global: substring= yes branching= no wbranch= no em: prior= dmix b= 0 maxiter= 50 distance= 1e-05 data: n= 576 N= 6 sample: seed= 0 seqfrac= 1 Dirichlet mixture priors file: prior30.plib Letter frequencies in dataset: A 0.045 C 0.017 D 0.045 E 0.057 F 0.040 G 0.083 H 0.043 I 0.038 K 0.059 L 0.104 M 0.010 N 0.033 P 0.033 Q 0.036 R 0.075 S 0.094 T 0.062 V 0.052 W 0.012 Y 0.059 Background letter frequencies (from dataset with add-one prior applied): A 0.045 C 0.018 D 0.045 E 0.057 F 0.040 G 0.082 H 0.044 I 0.039 K 0.059 L 0.102 M 0.012 N 0.034 P 0.034 Q 0.037 R 0.074 S 0.092 T 0.062 V 0.052 W 0.013 Y 0.059 ******************************************************************************** ******************************************************************************** MOTIF 1 width = 27 sites = 6 llr = 314 E-value = 1.4e-020 ******************************************************************************** -------------------------------------------------------------------------------- Motif 1 Description -------------------------------------------------------------------------------- Simplified A 2::::2:::2:::::73::::2::::2 pos.-specific C :::::::::::::::::::52:::::7 probability D :::::::::2:::2::5:::::::::: matrix E ::3:::5::2:::2::::::::::2:: F :a::::::::::::::::::::::::: G ::2:::::::::::2::8::::2:::: H ::::::2::255:222::::2::2::: I ::::2::23:::::::::23::::::: K ::::::::::::33:::::::2::::: L ::::7::8::::::::2:8:::8::2: M ::::::::::::2:::::::::::::: N ::3:::::::::::32::::::::::: P :::::2:::::::::::2:::::::7: Q 3::::53::2::::::::::2:::::: R 3:::::::::::::2::::::5:2::: S ::25:2:::2::5:::::::2::3::: T 2::5:::::::::2::::::32:22:: V ::::2:::7:::::2::::2:::2322 W ::::::::::::::::::::::::::: Y ::::::::::55::::::::::::3:: bits 6.4 5.8 5.1 4.5 * Relative 3.8 * * * Entropy 3.2 * * * ** * * * ** (75.5 bits) 2.6 ********* *** ***** * ** 1.9 *************************** 1.3 *************************** 0.6 *************************** 0.0 --------------------------- Multilevel QFESLQELVxHHSKNADGLCTRLSVPC consensus R NT Q I YYK A I Y sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------------- FYN_HUMAN 72 1.42e-27 NGGYYITTRA QFETLQQLVQHYSERAAGLCCRLVVPC SRC_HUMAN 72 6.58e-26 SGGFYITSRT QFNSLQQLVAYYSKHADGLCHRLTTVC HCK_HUMAN 72 2.70e-24 NGGFYISPRS TFSTLQELVDHYKKGNDGLCQKLSVPC ABL1_HUMAN 65 2.61e-22 DGKLYVSSES RFNTLAELVHHHSTVADGLITTLHYPA TEC_HUMAN 73 9.61e-21 PKKYYLAEKH AFGSIPEIIEYHKHNAAGLVTRLRYPV SHC1_HUMAN 61 3.27e-16 PEGVVRTKDH RFESVSHLISYHMDNHLPIISAGSELC LQQPV -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- FYN_HUMAN 1.4e-27 71_[1] SRC_HUMAN 6.6e-26 71_[1] HCK_HUMAN 2.7e-24 71_[1] ABL1_HUMAN 2.6e-22 64_[1] TEC_HUMAN 9.6e-21 72_[1] SHC1_HUMAN 3.3e-16 60_[1]_5 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 1 width=27 seqs=6 FYN_HUMAN ( 72) QFETLQQLVQHYSERAAGLCCRLVVPC 1 SRC_HUMAN ( 72) QFNSLQQLVAYYSKHADGLCHRLTTVC 1 HCK_HUMAN ( 72) TFSTLQELVDHYKKGNDGLCQKLSVPC 1 ABL1_HUMAN ( 65) RFNTLAELVHHHSTVADGLITTLHYPA 1 TEC_HUMAN ( 73) AFGSIPEIIEYHKHNAAGLVTRLRYPV 1 SHC1_HUMAN ( 61) RFESVSHLISYHMDNHLPIISAGSELC 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 20 w= 27 n= 420 bayes= 6.10852 E= 1.4e-020 140 -244 -98 -38 -265 -235 -153 -177 25 -238 -38 -37 -162 262 160 -136 86 -163 -256 -282 -270 -240 -416 -427 444 -478 -439 -183 -444 -182 -95 -373 -347 -423 -497 -375 -411 -237 -175 -135 -97 -302 4 213 -343 66 -182 -301 -107 -361 -168 299 -202 -83 -221 62 -157 -280 -356 -338 -77 -166 -277 -333 -325 -318 -369 -233 -272 -366 -125 -107 -255 -256 -320 243 254 -232 -338 -410 -207 -240 -458 -399 -142 -484 -437 172 -390 267 91 -364 -344 -307 -408 -413 -276 121 -292 -371 111 -224 -143 -62 -304 -256 -144 -221 -105 -267 -54 -83 148 371 -181 0 -156 -200 -282 -344 -89 -371 -11 275 -380 -296 114 -274 -84 -323 -119 -95 -206 297 -198 -217 -201 -246 -361 -387 -235 -265 -458 -392 -124 -495 -427 136 -383 291 112 -370 -335 -290 -392 -422 -301 -80 -276 -366 -112 -192 -411 -396 -263 -472 -469 282 -406 -161 -40 -361 -354 -394 -445 -413 -219 354 -413 -461 141 -243 132 136 -237 -202 111 -170 -1 -227 -23 4 -128 173 -105 39 -86 -149 -245 -253 -290 -298 -345 -376 32 -443 328 -274 -367 -297 -153 -195 -354 -209 -343 -360 -354 -294 -58 284 -290 -298 -345 -376 32 -443 328 -274 -367 -297 -153 -195 -354 -209 -343 -360 -354 -294 -58 284 -47 -224 -130 -79 -264 -250 -187 -166 198 -241 298 -54 -187 -33 -78 194 -69 -161 -266 -295 -8 -250 136 138 -247 -203 113 -178 188 -235 -32 5 -135 13 -105 -105 84 -157 -254 -262 -34 -238 -63 -43 -239 16 125 -162 -20 -236 -38 302 -158 -14 50 -120 -109 77 -249 -255 366 -131 -109 -147 -283 -183 87 -212 -152 -292 -97 153 -242 -143 -242 -112 -161 -129 -305 -344 206 -234 337 -19 -278 -257 -251 -163 -144 -16 -83 -47 -222 -110 -244 -186 -179 -158 -310 -339 -121 -316 -235 -315 -433 337 -398 -382 -313 -493 -264 -178 45 -337 -358 -274 -346 -352 -361 -474 -235 -265 -458 -392 -124 -495 -427 136 -383 291 112 -370 -335 -290 -392 -422 -301 -80 -276 -366 -159 431 -481 -448 -236 -476 -511 302 -442 -145 -18 -378 -399 -412 -500 -413 -237 202 -388 -416 -41 187 -124 -95 -244 -257 94 -144 -81 -247 -33 -39 -182 129 -171 87 238 -137 -264 -286 97 -275 -197 -131 -342 -304 -198 -238 122 -295 -106 -107 -224 -49 280 -219 46 -238 -278 -346 -199 -262 -411 -368 -159 -21 -410 -46 -355 292 80 -329 -318 -282 -374 -366 -291 -119 -290 -368 -14 -188 -98 -54 -212 -231 91 -117 -34 -206 -8 -29 -155 -27 37 155 125 78 -237 -253 -21 -131 -158 85 -23 -258 -160 5 -114 -114 63 -98 -181 -92 -192 -163 79 203 -144 192 -65 -260 -260 -247 -280 -327 -337 -149 -239 -41 -104 -240 436 -205 -310 -227 -214 52 -357 -418 19 551 -469 -449 -392 -393 -509 -208 -481 -378 -198 -379 -388 -421 -488 -328 -299 -19 -462 -530 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 20 w= 27 nsites= 6 E= 1.4e-020 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.333333 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.500000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.000000 0.000000 0.166667 0.000000 0.166667 0.166667 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.166667 0.000000 0.000000 0.166667 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.166667 0.000000 0.000000 0.166667 0.000000 0.000000 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.166667 0.333333 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.333333 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.333333 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.666667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.166667 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 1 regular expression -------------------------------------------------------------------------------- [QR]F[EN][ST]LQ[EQ]L[VI]x[HY][HY][SK]KNA[DA]GL[CI]TRLS[VY]PC -------------------------------------------------------------------------------- Time 0.33 secs. ******************************************************************************** ******************************************************************************** MOTIF 2 width = 21 sites = 6 llr = 253 E-value = 2.3e-018 ******************************************************************************** -------------------------------------------------------------------------------- Motif 2 Description -------------------------------------------------------------------------------- Simplified A :::::::::28:2:::22::: pos.-specific C ::2:::::::::::::::::: probability D :::::::::3::::::::22: matrix E :::::::::3:a:::::22:2 F :35::::::::::::::2::2 G :::72:2::::::::::25:2 H ::3:::::::::::::::::: I :::::3::::::::::::2:: K :::25:::32:::::::::2: L :::::3:::::::7a52:::: M :::::2::::::::::::::2 N ::::2:2:2:::::::22:7: P ::::2::::::::::::2::3 Q ::::::::::::23:2::::: R :::2:::a3:::5::2::::: S ::::::5:2:2::::25:::: T ::::::2:::::::::::::: V :::::2::::::::::::::: W a:::::::::::::::::::: Y :7::::::::::2:::::::: bits 6.4 * 5.8 * 5.1 * 4.5 * Relative 3.8 * * ** Entropy 3.2 *** * ** * * (60.7 bits) 2.6 ****** * ****** ** 1.9 ********************* 1.3 ********************* 0.6 ********************* 0.0 --------------------- Multilevel WYFGKISRKDAERLLLSxGNP consensus FH L RE Q sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------------- FYN_HUMAN 1 2.87e-21 . WYFGKLGRKDAERQLLSFGNP RGTFLIRESE HCK_HUMAN 1 1.39e-20 . WFFKGISRKDAERQLLAPGNM LGSFMIRDSE SRC_HUMAN 1 4.11e-20 . WYFGKITRRESERLLLNAENP RGTFLVRESE SHC1_HUMAN 1 1.51e-17 . WFHGKLSRREAEALLQLNGDF LVRESTTTPG ABL1_HUMAN 1 5.90e-17 . WYHGPVSRNAAEYLLSSGING SFLVRESESS TEC_HUMAN 1 4.45e-15 . WYCRNMNRSKAEQLLRSEDKE GGFMVRDSSQ -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- FYN_HUMAN 2.9e-21 [2]_77 HCK_HUMAN 1.4e-20 [2]_77 SRC_HUMAN 4.1e-20 [2]_77 SHC1_HUMAN 1.5e-17 [2]_71 ABL1_HUMAN 5.9e-17 [2]_70 TEC_HUMAN 4.4e-15 [2]_78 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 2 width=21 seqs=6 FYN_HUMAN ( 1) WYFGKLGRKDAERQLLSFGNP 1 HCK_HUMAN ( 1) WFFKGISRKDAERQLLAPGNM 1 SRC_HUMAN ( 1) WYFGKITRRESERLLLNAENP 1 SHC1_HUMAN ( 1) WFHGKLSRREAEALLQLNGDF 1 ABL1_HUMAN ( 1) WYHGPVSRNAAEYLLSSGING 1 TEC_HUMAN ( 1) WYCRNMNRSKAEQLLRSEDKE 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 20 w= 21 n= 456 bayes= 6.22882 E= 2.3e-018 -326 -324 -382 -401 -127 -439 -431 -339 -394 -273 -178 -334 -387 -339 -402 -444 -403 -321 606 -235 -205 -247 -336 -331 278 -413 -124 -211 -329 -250 -105 -244 -310 -276 -350 -317 -319 -233 -32 330 -217 253 -366 -370 350 -418 242 -174 -352 -224 -88 -243 -337 -270 -372 -336 -309 -201 -67 39 -123 -320 -217 -251 -416 320 -326 -342 18 -428 -214 -146 -306 -205 -28 -262 -304 -322 -341 -435 -71 -279 -52 -67 -308 35 -178 -237 275 -298 -100 185 156 -47 -112 -143 -144 -223 -303 -314 -182 -234 -402 -385 -161 -446 -434 352 -363 121 280 -315 -354 -324 -417 -367 -243 155 -288 -346 -77 -175 -166 -246 -321 -57 -309 -278 -223 -366 -153 100 -233 -217 -291 269 124 -295 -337 -378 -276 -276 -407 -422 -451 -426 -280 -345 -126 -413 -261 -271 -301 -213 361 -399 -378 -429 -291 -481 -92 -294 -141 -92 -330 -269 -179 -231 232 -282 -87 178 -211 -20 183 36 -161 -220 -288 -322 141 -403 250 254 -391 -288 -255 -277 108 -337 -139 -93 -198 -24 -231 -212 -196 -240 -394 -395 403 -75 -323 -303 -299 -179 -402 -216 -320 -302 -102 -253 -305 -289 -361 15 -178 -94 -318 -428 -411 -548 -186 408 -591 -540 -532 -469 -532 -624 -436 -369 -557 -344 -590 -564 -531 -511 -559 -655 94 -256 -165 -107 -283 -285 -184 -209 3 -274 -84 -90 -205 128 277 -196 -172 -210 -258 27 -208 -270 -369 -298 -135 -439 -377 -32 -252 268 87 -300 -324 221 -307 -373 -285 -113 -270 -333 -263 -295 -462 -411 -154 -491 -440 -45 -400 307 81 -385 -347 -310 -408 -439 -332 -129 -298 -382 -60 -226 -145 -85 -201 -268 -189 -89 -5 189 27 -76 -189 151 64 16 -136 -111 -244 -280 116 -162 -163 -157 -259 -250 -258 -174 -143 -49 -70 123 -199 -132 -225 243 31 -173 -287 -323 144 -221 -44 117 103 28 -133 -146 -3 -212 -12 169 160 12 -104 -95 -81 -130 -231 -209 -88 -312 88 85 -361 282 -275 69 -156 -365 -160 -76 -241 -125 -256 -208 -227 -261 -338 -388 -209 -312 78 -195 -366 -260 -174 -287 13 -417 -222 440 -273 -175 -310 -174 -218 -331 -337 -392 -14 -194 -115 85 99 4 -188 -87 -69 -178 275 -67 320 -50 -162 -140 -111 -89 -233 -215 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 20 w= 21 nsites= 6 E= 2.3e-018 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.000000 0.166667 0.000000 0.000000 0.500000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.500000 0.000000 0.000000 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.333333 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.500000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.166667 0.000000 0.000000 0.333333 0.166667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.333333 0.333333 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.500000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 1.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.166667 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.166667 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.166667 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.166667 0.000000 0.500000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.166667 0.166667 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 2 regular expression -------------------------------------------------------------------------------- W[YF][FH]GK[IL]SR[KR][DE]AER[LQ]LLSxGNP -------------------------------------------------------------------------------- Time 0.54 secs. ******************************************************************************** ******************************************************************************** MOTIF 3 width = 15 sites = 6 llr = 188 E-value = 6.6e-012 ******************************************************************************** -------------------------------------------------------------------------------- Motif 3 Description -------------------------------------------------------------------------------- Simplified A ::::::::::3:::2 pos.-specific C ::::::::::::2:: probability D :::2::::::::::: matrix E :::8:7::::::::: F ::::::::::::::: G :::::::::8::::: H 2:::::::::::::: I :5:::::::::::2: K ::2:::::522:::: L 7::::::::::::8: M 2:::::::::::::: N ::::::::::::::: P ::::::::5:::::: Q ::::::::::3:::: R ::8::::::::2::: S ::::8:23::2:5:7 T ::::2387::::::2 V :5::::::::::2:: W ::::::::::::::: Y :::::::::::82:: bits 6.4 5.8 5.1 4.5 Relative 3.8 * Entropy 3.2 *** ***** * (45.1 bits) 2.6 *************** 1.9 *************** 1.3 *************** 0.6 *************** 0.0 --------------- Multilevel LIRESETTKGAYSLS consensus V T SP Q sequence -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 sites sorted by position p-value -------------------------------------------------------------------------------- Sequence name Start P-value Site ------------- ----- --------- --------------- FYN_HUMAN 26 3.41e-17 LSFGNPRGTF LIRESETTKGAYSLS IRDWDDMKGD SRC_HUMAN 26 1.07e-16 LNAENPRGTF LVRESETTKGAYCLS VSDFDNAKGL SHC1_HUMAN 22 2.08e-15 EALLQLNGDF LVRESTTTPGQYVLT GLQSGQPKHL HCK_HUMAN 26 4.44e-14 LAPGNMLGSF MIRDSETTKGSYSLS VRDYDPRQGD ABL1_HUMAN 24 1.93e-13 LLSSGINGSF LVRESESSPGQRSIS LRYEGRVYHY TEC_HUMAN 55 2.79e-10 GEGSSGFRHY HIKETTTSPKKYYLA EKHAFGSIPE -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 block diagrams -------------------------------------------------------------------------------- SEQUENCE NAME POSITION P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- FYN_HUMAN 3.4e-17 25_[3]_58 SRC_HUMAN 1.1e-16 25_[3]_58 SHC1_HUMAN 2.1e-15 21_[3]_56 HCK_HUMAN 4.4e-14 25_[3]_58 ABL1_HUMAN 1.9e-13 23_[3]_53 TEC_HUMAN 2.8e-10 54_[3]_30 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 in BLOCKS format -------------------------------------------------------------------------------- BL MOTIF 3 width=15 seqs=6 FYN_HUMAN ( 26) LIRESETTKGAYSLS 1 SRC_HUMAN ( 26) LVRESETTKGAYCLS 1 SHC1_HUMAN ( 22) LVRESTTTPGQYVLT 1 HCK_HUMAN ( 26) MIRDSETTKGSYSLS 1 ABL1_HUMAN ( 24) LVRESESSPGQRSIS 1 TEC_HUMAN ( 55) HIKETTTSPKKYYLA 1 // -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific scoring matrix -------------------------------------------------------------------------------- log-odds matrix: alength= 20 w= 15 n= 492 bayes= 6.33985 E= 6.6e-012 -209 -249 -419 -353 -122 -458 11 -11 -338 283 258 -329 -306 -258 -354 -380 -275 -90 -260 -336 -182 -230 -429 -426 -254 -494 -521 371 -413 -112 -1 -360 -401 -406 -485 -424 -255 283 -401 -427 -258 -269 -392 -379 -445 -415 -263 -329 -23 -395 -238 -248 -292 -181 355 -379 -354 -404 -282 -466 -356 -550 -81 404 -586 -512 -504 -455 -438 -593 -402 -337 -492 -286 -545 -512 -485 -479 -557 -638 -74 -158 -274 -338 -318 -315 -370 -278 -269 -369 -152 -99 -242 -276 -312 296 122 -306 -334 -389 -109 -394 -13 339 -436 -312 -310 -304 -145 -382 -190 -128 -241 -70 -286 -246 173 -269 -442 -449 -115 -184 -289 -337 -330 -366 -368 -175 -272 -357 -82 -110 -282 -230 -327 52 354 -163 -336 -443 -100 -180 -285 -334 -330 -347 -368 -187 -273 -360 -92 -111 -276 -234 -327 136 332 -174 -338 -437 -118 -318 -238 -198 -374 -332 -296 -289 245 -342 -182 -181 393 -143 -163 -253 -244 -274 -372 -426 -121 -321 -222 -300 -427 338 -385 -374 -56 -485 -254 -164 -322 -319 -335 -272 -345 -348 -352 -464 225 -228 -66 -12 -250 -211 -147 -173 127 -233 -31 -16 -144 249 -85 40 -98 -151 -251 -269 -184 -247 -307 -294 73 -387 -132 -212 -222 -258 -106 -223 -296 -237 59 -299 -299 -230 -65 351 -12 216 -266 -243 -125 -268 -270 -27 -220 -147 31 -139 -218 -191 -274 217 -13 113 -202 67 -235 -265 -458 -392 -124 -495 -427 136 -383 291 112 -370 -335 -290 -392 -422 -301 -80 -276 -366 58 -154 -281 -336 -322 -297 -374 -279 -275 -370 -154 -109 -240 -275 -318 287 124 -290 -338 -396 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 position-specific probability matrix -------------------------------------------------------------------------------- letter-probability matrix: alength= 20 w= 15 nsites= 6 E= 6.6e-012 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.666667 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.833333 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.666667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.500000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.333333 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.833333 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.500000 0.000000 0.166667 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.833333 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.166667 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.000000 0.666667 0.166667 0.000000 0.000000 0.000000 -------------------------------------------------------------------------------- -------------------------------------------------------------------------------- Motif 3 regular expression -------------------------------------------------------------------------------- L[IV]RES[ET]T[TS][KP]G[AQ]YSLS -------------------------------------------------------------------------------- Time 0.68 secs. ******************************************************************************** ******************************************************************************** SUMMARY OF MOTIFS ******************************************************************************** -------------------------------------------------------------------------------- Combined block diagrams: non-overlapping sites with p-value < 0.0001 -------------------------------------------------------------------------------- SEQUENCE NAME COMBINED P-VALUE MOTIF DIAGRAM ------------- ---------------- ------------- ABL1_HUMAN 5.78e-42 [2(5.90e-17)]_2_[3(1.93e-13)]_26_\ [1(2.61e-22)] FYN_HUMAN 5.95e-55 [2(2.87e-21)]_4_[3(3.41e-17)]_31_\ [1(1.42e-27)] HCK_HUMAN 5.54e-48 [2(1.39e-20)]_4_[3(4.44e-14)]_31_\ [1(2.70e-24)] SHC1_HUMAN 1.77e-38 [2(1.51e-17)]_[3(2.08e-15)]_24_\ [1(3.27e-16)]_5 SRC_HUMAN 1.11e-51 [2(4.11e-20)]_4_[3(1.07e-16)]_31_\ [1(6.58e-26)] TEC_HUMAN 2.32e-35 [2(4.45e-15)]_33_[3(2.79e-10)]_3_\ [1(9.61e-21)] -------------------------------------------------------------------------------- ******************************************************************************** ******************************************************************************** Stopped because nmotifs = 3 reached. ******************************************************************************** CPU: sten-0-1.local ********************************************************************************