Publications from 1995-2005

Shen, J.,Terry, M.B., Gammon, M.D., Wang, L.W., Wang,Q., Zhang, F.F., Teitelbaum, S.L., Neugut, A., Santella, R.M. Genetic polymorphisms in the DNA repair gene XRCC1 and, interaction with PAH-DNA adducts on breast cancer risk Cancer Epi. Biomarkers & Prevention 14, 336-42, 2005

Zhang, Y.J., Chen, Y., Ahsan,H., Lunn, RM., Chen, S.Y., Lee,P.H., Chen, C.J. and Santella, R.M. Silencing of glutathione S-transferase P1 by promoter hypermethylation and its relationship to environmental chemical carcinogens in hepatocellular carcinoma. Cancer Letters 221, 135-143, 2005.

Ahsan, H., Whittemore, A.S., Chen, Y., Senie,R.T., Hamilton, S.P., Wang, Q., Gurvich, I., Santella,R.M. Variants in estrogen-biosynthesis genes CYP17 and Cyp 19 and breast cancer risk: a family-based genetic association study. Breast Cancer Research 7, R71-R81, 2005.

Kennedy, D.O., Agrawal, M., Shen, J., Terry, M.B., Zhang, F.F., Senie, R.T., Motykiewicz, G., and Santella, R.M. DNA repair capacity of lymphoblastoid cell lines from sisters discordant for breast cancer. Journal of the National Cancer Institute 97, 127-132, 2005.    

Kelley, M.J., Glaser, E.M., Herndon, J.E, Becker, F., Zhang, Y-J., Santella, R.M., Carmella, S.G., Hecht, S.S., Gallot, L., Schilder,L., Crowell, J.A., Perloff, M., Folz, R.J., and Bergan, R.C. Safety and efficacy of weekly oral oltipraz in chronic smokers. Cancer Epidemiology, Biomarkers & Prevention Cancer Epi. Biiomarkers & Prevention 14 892-899, 2005.

Chen, J., Gammon, M.D., Chan, W., Palomeque, C., Wetmur, J.G., Kabat, G.C., Teitelbaum, S.T., Britton, J.A., Terry, M.B., Neugut, A.I., and Santella, R.M. One-Carbon metabolism, MTHFR polymorphisms and risk of breast cancer. Cancer Research 65,1606-1614, 2005.

Kristal, A.R., King, I.B., Albanes, D., Pollak, M.N., Stanzyk, F.Z., Santella, R.M., and Hoque, A. Centralized blood processing for the Selenium and Vitamin E Cancer Prevention Trial: Effect of delayed processing on carotenoids, tocopherols, insulin-like growth factor-1, insulin-like growth factor binding protein3, steroid hormones and lymphocyte viability. Cancer Epi. Biomarkers & Prevention 14, 727-730, 2005.

Machella, N., Regoli, F., Santella, R.M. Immunofluorescent detection of 8-oxo-dG and PAH bulky adducts in fish liver and mussel digestive gland. Aquatic Toxicology 71 335-343, 2005.

Wolff, M.S., Teitelbaum, S.L., Lioy, P.J., Santella, R.M., Wang, R.Y., Jones, R.L., Caldwell, K.L., Sjodin, A., Turner, W.E., Li, W., Georgopoulos, P., and Berkowitz, G.S. Exposures among pregnant women near the World Trade Center site on 11 September 2001. Environ. Health Perspectives 113, 739-748, 2005.

Gammon, M.D., Eng, S.M., Teitelbaum, S.L., Britton, J.A., Kabat, G.C., Hatch, M., Paykin, A.B., Neugut, A.I. and Santella, R. M. Environmental Tobacco Smoke and Breast Cancer Incidence. Environmental Research 92, 176-185, 2004.

Chen, S.Y., Liu, T.Y., Shun, C.T., Wu, M.S., Lu, T.H., Lin, J.T., Sheu, J.C., Santella, R.M. and Chen, C.J. Modification effects of GSTM1, GSTT1 and CYP2E1 polymorphisms on associations between raw salted food and incomplete intestinal metaplasia in a high-risk area of stomach cancer. Int. J. Cancer 108, 606-612, 2004.

Machella, N., Regoli, F., Cambria, A., and Santella, R.M. Application of an immunoperoxidase staining method for detection of 7,8-dihydro-8-oxodeoxyguanosine as a biomarker of chemical-induced oxidative stress in marine organisms. Aquatic Toxicology 67, 23-32,2004.

Terry, M.B., Gammon, M.D., Eng, S., Paykin, A., Wang, Q., Hayes, S., Neugut, A., Teitelbaum, S.L., and Santella, R.M. Polymorphism in the DNA repair gene XPD, polycyclic aromatic hydrocarbon-DNA adducts, cigarette smoking and breast cancer risk. Cancer Epi. Biomarkers & Prevention 13, 2053-2058, 2004.

Machella, N., Regoli, F., Cambria, A., and Santella, R.M. Oxidative damage to DNA:an immunohistochemical approach for detection of 7,8-dihydro-8-oxodeoxyguanosine in marine organisms. Marine Environmental Res. 58, 725-729, 2004.

Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Lee, P.H., Chen,C.J., and Santella, R.M. Inactivation of the DNA repair gene 0⁶-Methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B₁- DNA adducts and p53 mutation in hepatocellular carcinoma Int. J. Cancer 103, 440-444, 2003.

Singh, R., McEwan, M., Lamb, J.H., Santella, R.M. and Farmer, P.B. An improved liquid chromatography-mass spectrometry/mass spectrometry method for the determination of 8-hydroxy-2'-deoxyguanosine in DNA samples using immunoaffinity column purification. Rapid Communications in Mass Spectrometry 17; 126-134, 2003.

Gaspari. L., Chang, S-S., Santella, R.M., Garte, S., Pedotti, P. and Taioli, E. Polycyclic aromatic hydrocarbon-DNA adducts in human sperm as a marker of DNA damage and infertility. Mutation Research, Genetic Toxicology and Environmental Mutagenesis 535, 155-160, 2003.

Krebs, C., Koestner, W., Nissen, M., Welge, V., Parusel,I., Malavasi, F., Leiter, E., Santella, R.M., Haag, F. and Koch-Nolte,F. Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine Analytical Biochem 314: 108-115, 2003.

Faraglia, B., Chen,S.Y., Gammon, M.D., Zhang, Y.J., Teitelbaum, S., Neugut, A.I., Ahsan, H., Garbowski, G.C., Hibshoosh, H., Lin, D., Kadlubar, F.F., and Santella, R.M. Evaluation of 4-aminobiphenyl-DNA adducts in human breast cancer: The influence of tobacco smoke Carcinogenesis 24, 719-725, 2003.

Gammon, M.D. and Santella, R.M. Correspondence re:Gammon et. al., Environmental toxins and breast cancer on Long Island. I. Polycyclic aromatic hydrocarbon DNA adducts. Cancer Epidemiology, Biomarkers & Prevention 11, 677-685, 2003.

Ahsan, H., Chen, Y., Wang, Q., Slovkovich, V., Graziano, J.H., and Santella, R.M. DNA Repair Gene XPD and Susceptibility to Arsenic-induced Hyperkeratosis. Toxicology Letters 143, 123-131, 2003.

Weiserbs, K.F., Jacobson, J.S., Begg, M.D., Wang, L.W., Wang, Q., Agrawal, M., Norkus, E.P., Young, T.L. and Santella, R.M. A cross-sectional study of polycyclic aromatic hydrocarbon-DNA adducts and polymorphism of glutathione S-transferases among heavy smokers by race/ethnicity. Biomarkers 8, 142-155, 2003.

Rahman, M.H., Arslan, M.I., Chen, Y., Ali, S., Parvin, T., Wang, L.W., Santella, R.M., Ahsan, H. Polycyclic aromatic hydrocarbon-DNA adducts among rickshaw drivers in Dhaka City, Bangladesh. Int. Arch. Occup. Environ. Health 2003.

Singh, R., McEwan, M., Lamb, J.H., Santella, R.M. and Farmer, P.B. An improved liquid chromatography-mass spectrometry/mass spectrometry method for the determination of 8-hydroxy-2'-deoxyguanosine in DNA samples using immunoaffinity column purification. Rapid Communications in Mass Spectrometry 17; 126-134, 2003.

Carlson, N., Lechago, J., Richter, J., Sampliner, R.E., Peterson, L., Santella, R.M., Goldblum, J., Falk, G., Ertan, A. and Younes,M. Acid suppression therapy (AST) may not alter malignant progression in Barrett's metaplasia (BM) showing p53 protein accumulation Amer. J. Gastroenterlogy 97, 340-345, 2002.

Perera, F.P., Hemminki, K., Jedyrychowski, W., Whyatt, R., Hsu, Y., Campbell, R. Santella,R.M., O'Neill, P. DNA Damage from environmental carcinogens is associated with somatic gene mutation in newborns. Cancer Epi. Biomarkers & Prevent. 11, 1134-1137, 2002.

Kessel, M., Liu, S.X., Xu, A., Santella, R. and Hei, T.K. Arsenic induces oxidative DNA damage in mammalian cells Molecular and Cellular Biochemistry 234/235 301-308, 2002.

Zhang, Y.J., Ahsan, H., Chen, Y., Lunn, R., Wang, L.Y., Chen, S.Y., Lee, P.H., Chen, C.J. and Santella, R.M. High frequency of promoter hypermethylation of the RASSF1A and p16 genes and its relationship to aflatoxin B1-DNA adduct levels in human hepatocellular carcinoma Molecular Carcinogenesis35, 85-92, 2002.

Zhang, Y.J., Chen, Y., Ahsan, H., Lunn, R.M., Lee, P.H., Chen,C.J., and Santella, R.M. Inactivation of the DNA repair gene 06-Methylguanine-DNA methyltransferase by promoter hypermethylation and its relationship to aflatoxin B1- DNA adducts and p53 mutation in hepatocellular carcinoma Int. J. Cancer.

Sun, C.A., Wu, D.M., Wang, L.Y., Chen, C.J., You, S.L. and Santella, R.M. Determinants of formation of aflatoxin-albmin adducts: a seven-township study in Taiwan British J Cancer 87: 966-970, 2002

Motykiewicz, G., Faraglia, B. Wand, L., Terry, M.B., Senie, R.T. and Santella, R.M. Removal of benzo(a)pyrene diol epoxide (BPDE)-DNA adducts as a measure of DNA-repair capacity in lymphoblastoid cell lines from sisters discordant for breast cancer. Environmental and Molecular Mutagenesis 40, 93-100, 2002.

Gammon, M.D., Santella, R.M., Neugut, A.I., Eng, S.M., Paykin, A., Teitelbaum, S.L., Levin, B., Terry, M.B., Young, T.L., Wang, L., Wang, Q., Britton, J.A., Wolff, M.S., Stellman, S.D., Hatch, M., Kabat, G., Senie, R., Garbowski, G., Maffeo, C., Montalvan, P., Kemeny, M., Citron, M., Schnabel, F., Schuss, A., Vinceguerra, V. PAH-DNA adducts and the risk of breast cancer among women on Long Island. Cancer Epi. Biomarkers & Prevention, 11, 677-685, 2002.

Gammon, M.D., Wolff, M.S., Neugut, A. I., Eng, S.M., Teitelbaum, S.L., Britton, J.A., Terry, M.B.,Levin, B., Stellman, S.D., Kabat, G., Hatch, M., Senie, R., Berkowitz, G., Bradlow, H.L., Garbowski, G., Maffeo, C., Montalvan, P. Kemeny, M., Citron. M., Schnabel, F., Schuss, A., Hajdu, S., Vinceguerra, V. , Niguidula, N., Ireland, K. and Santella, R.M.,Environmental Toxins and breast cancer on Long Island. II. Organochlorine compound levels in blood. Cancer Epi. Biomarkers & Prevention 11, 686-691, 2002.

Gammon, M.D., Neugut, A.I., Santella, R.M., Teitelbaum, S.L., Britton J.A., Terry, M.B., Eng, S.M., Wolff, M.S., Stellman, S.D., Kabat, G., Levin, B., Bradlow, H.L., Hatch, M., Beyea, J., Camann, D., Trent, M., Senie, R., Maffeo, C., Montalvan, P., Garbowski, G., Berkowitz, G., Kemeny, M., Citron, M., Schnabel, F., Schuss, A., Hajdu, S., Vinceguerra, V. The Long Island Breast Cancer Study Project: description of a multi-institutional collaboration to identify environmental risk factors for breast cancer. Breast Cancer Research and Treatment 74, 235-254, 2002.

Zhang, Y.J., Chang, S.Y., Hsu, T.M., and Santella, R.M. Immunohistochemical detection of malondialdehyde-DNA adducts in human oral mucosa cells. Carcinogenesis, 23, 207-211, 2002.

Chen, S.Y., Wang, L.Y., Lunn, R.M., Tsai, W.Y., Lee, P.H., Lee, C.S., Ahsan, H., Zhang, Y.J., Chen, C.J., Santella, R.M. Polycyclic aromatic hydrocarbon-DNA adducts in liver tissues of hepatocellular carcinoma patients and controls. Int. J. Cancer 99, 14-21, 2002.

Zhang, Y.J., Chen, S.Y., Chen, C.J., Santella, R.M. Polymorphism of the cyclin D1 gene in hepatocellular carcinoma. Molecular Carcinogenesis 33, 125-129, 2002.

Chen, S.Y., Chen, C.J., Chou, S.R., Hsieh, L.L., Wang, L.Y., Tsai, W.Y., Ahsan, H., Santella, R.M. Association of aflatoxin B1-albumin adduct levels with hepatitis B surface antigen status among adolescents in Taiwan. Cancer Epi. Biomarkers & Prevention 10, 1223-1226, 2001.

Ahsan, H., Wang, L.Y., Chen, C.J., Tsai, W.Y., Santella, R.M. Intraindividual variability in aflatoxin-albumin adduct levels and effects of hepatitis B and C virus infection and glutathione S-transferase M1 and T1 genotype. Envir. Health Persp. 109, 833-837, 2001.

Sun, C.A., Wang, L.Y., Chen, C.J., Lu, S.N., You, S.L., Wang, L.W., Wang, Q., Wu, D.M., Santella, R.M. Genetic polymorphisms of glutathione S-transferase M1 and T1 associated with susceptibility to aflatoxin-related hepatocarcinogenesis among chronic hepatitis B carriers: A nested case-control study in Taiwan. Carcinogenesis 22, 1289-1294, 2001.

Motykiewicz, G., Malusecka, E., Michalsecka, E., Kalinowska, E., Wloch, J., Butkiewicz, D., Mazurek, A., Lange, D., Perera, F.P., Santella, R.M. Immunoperoxidase detection of polycylic aromatic hydrocarbon-DNA adducts in breast tissue sections. Cancer Detection and Prevention 25, 328-335, 2001.

Simpson, C.D., Wu, M.T., Christiani, D.C., Santella, R.M., Carmella, S.G. and Hecht, S.S. Determination of r-7,t-8,9,c-10-tetrahydrozy-7,8,9,10-tetrahydrobenzo[a]pyrene in human urine by gas chromatography-negative ion chemical ionization-mass spectrometry. Chem. Res. Toxicol. 13, 271-280, 2000.

Chen, S.Y., Chen, C.J., Tsai, W.Y., Ahsan, H., Liu, T.Y., Lin, J.T. Santella, R.M. Associations of plasma aflatoxin B1-albumin adducts level with plasma selenium level and genetic polymorphisms of glutathione S-transferase M1 and T1. Nutrition and Cancer 38, 179-185, 2000.

Banerjee, R., Caruccio, L., Zhang, Y.J., McKercher, S., Santella, R.M. Effects of carcinogen induced transcription factors on the activation of hepatitis B virus expression in human hepatoblastoma HEPG2 cells and its implication on hepatocellular carcinomas. Hepatology 2000.

Zhang, Y.J., Chen, S.Y., Tsai, W.Y., Ahsan, H., Lunn, R.M., Wang, L.Y., Chen,C.J. and Santella, R.M. Expression of cytochrome P450 1A1/2 and 3A4 in liver tissues of hepatocellular carcinoma cases and controls from Taiwan and their relationship to Hepatitis B virus and aflatoxin B1- and 4-aminobiphenyl-DNA adducts. Biomarkers 2000.

Santella, R.M., Gammon, M., Motykiewicz, G., Young T.L., Zhang,Y.J., Hayes, S.C., Terry, M.B., Schoenberg, J.A., Brinton, L.A., Bose, S., Teitelbaum, S.L., Hibshoosh, H. Immunohistochemical analysis of polycyclic aromatic hydrocarbon-DNA adducts in breast tumor tissue. Cancer Letters 154, 143-149, 2000.

Poirier, M.C., Santella, R.M. and Weston, A. Carcinogen macromolecular adducts and their measurement. Carcinogenesis 21, 353-359, 2000.

Whyatt,R.M., Perera, F.P., Jedrychowski, W., Santella, R.M., Garte, S., Bell,D.A. Association between polycyclic aromatic hydrocarbon-DNA adduct levels in maternal and newborn white blood cells and glutathione S-transferase P1 and CYP1A1 polymorphisms. Cancer Epi, Biomarkers, & Prevention 8, 207-212, 2000.

Fontana, R.J., Lown, K.S., Paine, M.F., Fortlage, L., Santella, R.M., Felton, J.S., Knize, M.G., Greenberg, A., Watkins, P.B. Effects of a chargrilled meat diet on expression of CYP3A4, CYP1A, and P-glycoprotein levels in healthy voluneteers. Gastroenterology 11 789-98, 1999.

Xu, A., Wu, L.J., Santella, R.M. and Hei, T. Role of oxyradiacals in mutagenicity and DNA damage induced by crocidolite asbestos in mammalian cells Cancer Res. 59, 5922-5926, 1999.

Yao, Y., Slosberg, E.D., Wang, L., Hibshoosh, H., Zhang, Y.J., Xing, W.Q., Santella, R.M., and Weinstein, I.B. Increased susceptibility to carcinogen-induced mammary tumors in MMTV-Cdc25B transgenic mice Oncogene 18, 5159-5166, 1999.

Northridge, M.E., Yankura, J., Kinney, P.L., Santella, R.M., Shepard, P., Riojas, Y., Aggarwal, M., Strickland, P., and the Earth Crew Diesel exhaust exposure among adolescents in Harlem: a community-driven study. Amer. J. Public Health 89, 998-1002, 1999.

Santella, R.M. Immunologic methods for detection of DNA damage in humans. Cancer Epi, Biomarkers & Prevention 8, 733-739, 1999.

Yu, M.W., Chiu, Y.H., Yang, S.Y., Santella, R.M., Chern, H.D., Liaw,Y.F., Chen, C.J. Cytochrome P4501A1 genetic polymorphisms and risk of hepatocellular carcinoma among chronic hepatitis B carriers Brit. J. Cancer 80, 598-603, 1999.

Hoque, A., Patt, Y.Z., Yoffe, B., Groopman, J.D., Greenblatt, M.S., Zhang, Y.J., and Santella, R.M. Does aflatoxin B1 play a role in the etiology of hepatocellular carcinoma (HCC) in the United States (U.S.)? Nutrition and Cancer 35, 27-33, 1999.

Romano, G., Sgambato, A., Boninsegna, A., Flamini, G., Curigliano, G., Yang, Q., LaGioia, V., Signorelli, C., Ferro, A., Capelli, G., Santella, R.M., and Cittadini, A. Evaluation of polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral cells by an immunohistochemical assay. Cancer Epi. Biomarkers & Prevention 8, 91-96, 1999.

Zhao,J.F., Zhang,Y.J., Kubilus, J., Jin, X.H., Santella, R.M., Athar, M., Wang, Z.Y., Bickers, D.R. Reconstituted 3-dimenstional human skin as a novel in vitro model for studies of carcinogenesis Biochem. Biophys. Res. Commun. 254 49-53, 1999.

Calderon-Garciduenas, L., Wang, L.W., Zhang, Y.J., Rodriguez-Alcaraz, A., Osnaya, N., Villarreal-Calderon, A., Santella, R.M. 8-Hydroxy-2'deoxyguanosine, a major mutagenic oxidative DNA lesion and DNA strand breaks in nasal respiratory epithelium of children exposed to urban pollution. Environ. Health Persp. 107, 469-474, 1999.

Yu, M.W., Chiu, Y.H., Chiang, Y.C., Chen, C.H., Lee, T.H., Santella, R.M., Chern, H.D., Liaw, Y.F., and Chen, C.J. Plasma carotenoids, glutatione S-transferase M1 and T1 genetic polymorphisms and risk of hepatocellular carcinoma: independent and interactive effects. Amer. J. Epi.149, 621-629, 1999.

Yao, Y.J., Zhang, H., Lee, P.K., Ahsan, H., Chen,C.J., Lee, P.O., Peacocke, M., Santella, R.M., and Tsou,H.C. PTEN/MMAC1 mutations in hepatocellular carcinomas. Oncogene 18, 3181-3185, 1999.

Tang, D.L., Rundle, A., Warburton, D., Santella, R.M., Tsai, W.Y., Chiamprasert, S., Hsu, Y.Z., and Perera, F.P. Associations between both genetic and environmental biomarkers and lung cancer: evidence of a greater risk of lung cancer in women smokers. Carcinogenesis 19, 1949-1954, 1998.

Begemann, M., Kashimawo, S.A., Lunn, R.M., Delohery, T., Choi, Y.J.A., Kim, S., Heitjan, D.F., Santella, R.M., Schiff, P.B., Bruce, J.N., and Weinstein, I.B. Growth inhibition induced by Ro31-8220 and calphostin C in human glioblastoma cell lines is associated with apoptosis and inhibition of CDC2 kinase. Anticancer Res. 18, 3139-3152, 1998.

Zhang, Y.J., Weksler, B.B., Wang, L.Y., Schwartz, J. and Santella, R.M. Immunohistochemical detection of polycyclic aromatic hydrocarbon-DNA damage in human blood vessels of smokers and non-smokers Atherosclerosis 140, 325-331, 1998.

Motykiewicz, G., Michalska, J., Pendzich, J., Malusecka, E., Strozyk,M., Kalinowska, E., Butkiewicz, D., Mielzynska, D., Midro, A., Santella, R.M., Chorazy, M. A molecular epidemiology study in women from Upper Silesia, Poland. Toxicology Let. 96,97, 195-202, 1998.

Whyatt, R.M., Bell, D.A., Jedrychowski, W., Santella, R.M., Garte, S.J., Cosma,G., Manchester, D.K., Young, T.L., Cooper, T.B., Ottman, R., Perera, F.P. Polycyclic aromatic hydrocarbon-DNA adducts in human placenta and modulation by CYP1A1 induction and genotype. Carcinogenesis 19, 1389-1392, 1998.

Sgambato, A., Zhang, Y.J., Ciaparrone, M., Soh, J.W., Cittadini, A., Santella, R.M., and Weinstein, I.B. Overexpression of p27Kip1 inhibits the growth of both normal and transformed human mammary epithelial cells. Cancer Res. 58, 3448-3454, 1998.

Whyatt, R.M., Santella, R.M., Jedrychowski, W., Garte, S.J., Bell, D.A., Ottman, R., Gladek-Yarborough, A., Cosma, G., Young, T.L., Cooper, T.B., Randall, M.C., Manchester, D.K., Perera, F.P. Relationship between ambient air pollution and DNA damage in Polish mothers and newborns Envir. Health Perspect. 106, 821-826, 1998.

Flamini, G., Romano, Gianpiero, R., Curigliano, G., Chiominto, A., Capelli, G., Boninsegna, A., Signorelli, C., Ventura, L., Santella, R.M., Sgambato, A., and Cittadini, A. 4-Aminobiphenyl-DNA adducts in laryngeal tissue and smoking habits: an immunohistochemical study. Carcinogenesis 19, 353-357, 1998.

Perera, F.P., Whyatt, R.M., Jedrychowski, W., Rauh, V., Manchester, D., Santella, R.M., and Ottman,R. Recent developments in molecular epidemiology - A study of the effects of environmental polycyclic aromatic hydrocarbons on birth outcomes in Poland Amer J. Epi. 147, 309-314, 1998.

Wang, L-Y, Chen, C.J., Zhang,Y-J., Tsai W-Y., Lee P-H., Feitelson, M.A., Lee, C-S., Santella, R.M. 4-Aminobiphenyl-DNA damage in liver tissue of hepatocellular carcinoma patients and controls. Amer, J. Epi. 147, 315-323, 1998.

Dickey, C., Santella, R.M., Hattis, D., Tang, D., Hsu, Y., Cooper, T., Young, T.L., and Perera, F.P. Variability in PAH-DNA adduct measurements in peripheral mononuclear cells: implications for quantitative cancer risk assessment. Risk Analysis 17, 649-656, 1997.

Romano, G., Mancini, R., Fedele, P., Curigliano, G., Flamini, G., Giovagnoli, M.R., Malara, N., Boninsegna, A., Vecchione, A, Santella, R.M., Cittadini, A. Immunohistochemical analysis of 4-aminobiphenyl-DNA adducts in oral mucosal cells of smokers and nonsmokers. Anticancer Research 17, 2827-2830, 1997.

Yu, M.W., Lien, H.P., Chiu, Y.H., Santella, R.M., Liaw, Y.F., and Chen, C.J. Effect of aflatoxin metabolism and DNA adduct formation on hepatocellular carcinoma among chronic hepatitis B carriers in Taiwan. J. Hepatology 27, 320-330, 1997.

Zhang, Y.J., Geacintov, N.E., and Santella, R.M. Development of monoclonal antibody recognizing benzo[c]phenanthrenediol epoxide-DNA adducts: application to immunohistochemical detection of DNA damage. Chem. Res. Tox. 10, 948-952, 1997.

Mathieu, A., Payne, J.F., Fancey, L.L., Santella, R.M., and Young, T.L. Polycyclic aromatic hydrocarbon DNA adducts in Beluga whales from the Artic. J. Toxicol. Environ. Health 51, 1-4, 1997.

Santella, R.M. DNA damage as an intermediate biomarker in intervention studies Exper. Med. Biol. 216, 166-171, 1997.

Sgambato, A. Zhang, Y.J., Santella, R.M., and Weinstein, I.B. Deregulated expression of p27Kip1 in human breast cancer. Clin. Cancer Res. 3, 1879-1887, 1997.

Lunn, R.M., Zhang, Y.J., Wang, L.Y., Chen, C.J., Lee, P.H., Lee, C.S., Tsai, W.Y., and Santella, R.M. P53 mutations, chronic hepatitis B virus infection, and aflatoxin exposure in hepatocellular carcinoma in Taiwan. Cancer Res. 57, 3471-3477, 1997.

Bowman, E.D., Rothman,N., Hackl,C., Santella, R.M. and Weston, A. Interindividual variation in the levels of certain urinary polycylic aromatic hydrocarbon metabolites following medicinal exposure to coal tar ointment. Biomarkers 2, 321-327, 1997.

Santella, R.M., Chen, C.J., Zhang, Y.J., Yu, M.W. and Wang, L.Y. Biological markers of aflatoxin B1 in hepatocellular cancer in Taiwan in Biomarkers Medical and Workplace Applications Mendelson, M.L., Mohr, L.C., and Peeters, J.P. editors, Joseph Henry Press Washington DC 355-364, 1998.

Mooney, L.A., Bell, D.A., Santella, R.M., Van Bennekum, A.M., Ottman, R., Paik, M., Blaner, W.S., Lucier, G.W., Covey, L., Young, T-L., Cooper, T.B., Glassman, A.H., Perera, F.P. Contribution of genetic and nutritional factors to DNA damage in heavy smokers. Carcinogensis 18, 101-107, 1997.

Gammon, M.D., Wolff, M.S., Neugut, A.I., Terry, M.B., Papadopoulos,K, Levin,B., Wang, Q, Santella, R.M. Temporal variation in chlorinated hydrocarbons in healthy women. Cancer Epidemiology, Biomarkers & Prevention. 6, 327-332, 1997.

Rousset, S., Nocentini, S., Santella, R.M., Moustacchi, E., 6,4,4'-Trimethylangelicin photoadduct immunodetection in DNA: induction and repair in fanconi anemia and normal human fibroblasts. J. Photochem. Photobiol. 38, 220-227, 1997.

Hsu, T-M., Zhang, Y-J., Santella, R.M. Immunoperoxidase quantitation of 4-aminobiphenyl- and polycyclic aromatic hydrocarbon-DNA adducts in exfoliated oral and urothelial cells of smokers and nonsmokers. Cancer Epi., Biomarkers & Prevention 6, 193-199, 1997.

Motykiewicz, G., Perera, F.P., Santella, R.M., Hemminki, K., Seemayer, N.H., Chorazy, M. Assessment of cancer hazard from environmental pollution in Silesia. Toxicology Let., 88, 169-173, 1996.

Gammon, M.D., Wolff, M.S., Neugut, A.I., Terry, M.B., Britton, J.A., Greenebaum, E., Hibshoosh, H., Levin, B., Wang, Q., Santella, R.M., Treatment for breast cancer and blood levels of chlorinated hydrocarbons. Cancer Epidemiology, Biomarkers & Prevention 5, 457-459. 1996.

Mumford, J.L., Williams, K., Wilcosky, T.C., Everson, R.B., Young, T.L., Santella, R.M., A sensitive color ELISA for detecting polycyclic aromatic hydrocarbon-DNA adducts in human tissues. Mutation Research, 359, 171-177, 1996.

Wang, L-Y., Hatch, M., Chen, C-J., Levin, B., You, S-L., Wu, M-H., Wu, W-P., Wang, L-W., Wang, Q., Huang, G-T., Yang, P-M., Lee, H-S., Santella, R.M. Aflatoxin exposure and the risk of hepatocellular carcinoma in Taiwan. Int. J. Cancer, 67, 620-625, 1996.

Burgeot, T., Bocquene, G., Porte, C., Dimeet, J., Santella, R.M., Garcia de la Parra, L.M., Pihol-Leszkowicz, A., Raoux, C., Galgani, R.F. Bioindicators of pollutant exposure in the Northwestern Mediterranean Sea. Mar. Ecol. Prog. Ser. 131, 124-141, 1996.

Widlak, P., Gryzbowska, E., Hemminki, K., Santella, R.M., Chorazy, M. 32P postlabelling of bulky human DNA adducts enriched by different methods including immunoaffinity chromatography. Chem.-Biol. Interactions 99, 99-107, 1996.

Curigliano, G., Zhang, Y-J., Wang, L-Y., Flamini, G., Alcini, A., Ratto, C, Giustacchini, M., Alcini, E., Cittadini, A., Santella, R.M. Immunohistochemical quantitation of 4-aminobiphenyl-DNA adducts and p53 nuclear overexpression in T1 bladder cancer of smokers and nonsmokers. Carcinogenesis 17, 911-916, 1996.

Chen, C-J., Yu, M-W., Liaw, Y-F., Wang, L-W., Chiamprasert, S., Matin, F., Hirvonen, A., Bell, D.A., Santella, R.M. Chronic hepatitis B carriers with null genotypes of glutathione S-transferase M1 and T1 who are exposed to aflatoxin are at increased risk of hepatocellular carcinoma. Amer. J. Human Genetic 59, 128-134. 1996.

Santella, R.M., Zhang, Y-J., Yarborough, A., Motykiewixz, G., Hsu, T-M., Lunn, R., Al-Atrash, J., Antisera to carcinogen-DNA adducts and their application in molecular epidemiology, Acta Medic Romana 34, 229-237, 1996.

Yarborough, A., Zhang, Y-J., Hsu, T-M., Santella, R.M. Immunoperoxidase detection of 8-hydroxydeoxyguanosine in aflatoxin B1-treated rat liver and human oral mucosal cells. Cancer Research 56, 683-688, 1996.

Chen, D-J., Wang, L-Y., Lu, S-N., Wu, M-H., You, S-L., Zhang,Y-J., Wang, L-W., Santella, R.M. Elevated aflatoxin exposure and increased risk of hepatocellular carcinoma. Hepatology 24, 38-42, 1996.

Sgambato, A., Han, E.K-H, Zhang, Y-J, Moon, R.C., Santella, R.M., Weinstein, I.B. Deregulated expression of cyclin D1 and other cell cycle-related genes in carcinogen-induced rat mammary tumors. Carcinogenesis 16, 2193-2198, 1995.

Perera, F.P., Mooney, L.A., Dickey, C.P., Santella, R.M., Bell, D., Blaner, W., Tang, D., Whyatt, R.M. Molecular epidemiology in environmental carcinogenesis. Enviromental Health Perspectives 104, 441-443, 1996.

Zhou, P., Jiang, W., Zhang, Y-J., Kahn, S.M., Schieren, J.I., Santella, R.M., Weinstein, I.B. Antisense to cyclin D1 inhibits growth and reverses the transformed phenotype of human esophageal cancer cells. Oncogene, 11, 571-580, 1995.

Tang, D., Santella, R.M., Blackwood, A.M., Young, T-L., Mayer, J., Jaretzki, A., Grantham, S., Tsai, W-Y., Perera, F.P. A molecular epidemiological case-control study of lung cancer. Cancer Epidemiology, Biomarkers & prevention 4, 341-346, 1995.

Hsu, T.M., Liu, T.M., Amin, S., Geacintov, N.E., Santella, R.M. Determination of stereospecificity of benzo[a]pyrene diol epoxide-DNA antisera with site-specifically modified oliogonucleotides. Carcinogenesis 16, 2263-2265, 1995.

Yu, M-W, Yarborough, A.G., Chiamprasert, S., Santella, R.M., Liaw, Y.-F., Chen, C.-J. Cytochrome P-450 2E1 and glutathione S-transferase M1 polymorphisms and susceptibility to hepatocellular carcinoma. Gastroenterology, 109, 1266-1273, 1995.

Mooney, L.A., Santella, R.M., Covey, L., Jeffrey, A.M., Bigbee, W., Randall, M.C., Cooper, T.B., Ottman, R., Tsai, W-Y, Wazneh, L., Glassman, A.H., Young, T-L, Perera, F.P. Decline of DNA damage and other biomarkers in peripheral blood following smoking cessation. Cancer Epidemiology, Biomarkers, and Prevention 4, 579-690, 1995.

Han, E.K-H., Sgambato, A., Jiang, W., Zhang, Y.J., Santella, R.M., Doki, Y., Cacace, A.M., Schieren, I., Weinstein,I.B. Stable overexpression of cyclin D1 in a human mammary epithelial cell line prolongs the S-phase and inhibits growth. Oncogene 10, 953-961, 1995.

Motykiewicz, G., Malusecka, E., Grzybowska, E., Chorazy, M., Zhang, Y-J, Perera, F.P., Santella, R.M. Immunohistochemical quantitation of polycyclic aromatic hydrocarbon-DNA adducts in human lymphocytes. Cancer Research, 55, 1417-1422, 1995.

Al-Atrash, J., Zhang, Y-J., Kin, D., Kadlubar, F.F., Santella, R.M. Quantitative immuno-histochemical analysis of 4-Aminobiphenyl-DNA in cultured cells and mice: Comparison to gas chromatography/mass spectroscopy analysis. Chemical Research in Toxicology, 8, 747-754, 1995.

Yin, B., Whyatt, R.M., Perera, F.P., Randall, R.C., Cooper, T., Santella, R.M. Determination of 8-hydroxydeoxyguanosine by an immunoaffinity chromatography-monoclonal antibody-based ELISA. Free Radical Biology & Medicine, 18, 1023-1032, 1995.

Zhang, Y.J., Hsu, T.M., Santella, R.M. Immunoperoxidase detection of polycyclic aromatic hydrocarbon-DNA adduct in oral mucosa cells of smokers and nonsmokers. Cancer Epidemiology, Biomarkers & Prevention 4, 133-138, 1995.

Santella, R.M. The Epidemiology of primary hepatocellular cancer. New Perspectives in Cancer Diagnoses and Management, 3, 3-14. 1995.

Santella, R.M., Perera, F.P., Young, T.L., Zhang, Y-J, Chiamprasert, S., Deliang, T., Wang, L.W., Beachman, A., Lin, J-H, and DeLeo, V.A. Polycyclic aromatic hydrocarbon DNA and protein adducts in coal tar treated patients and controls and their relationship to glutathione-S-transferase genotype. Mut Research, 334, 117-124. 1995.

Weinstein, I.B., Carothers, A.M., Santella, R.M., Perera, F. Molecular Mechanisms of mutagenesis and multistage carcinogenesis. In: The Molecular Basis of Cancer, Mendelsohn, Howley, Liotta and Israel, (Eds.), 1995.

Weinstein, I.B., Santella, R.M., Perera, F.P. The molecular biology and molecular epidemiology of cancer. In: The Science and Practice of Cancer Prevention and Control, Greenwald, P., Kramer, B.S. and Weed, D.L. (Eds.), Marcel-Dekker, 1995.

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