Hypothalamus

• Functional Hypothalamic Hypogonadism

• Congenital: GNRH Deficiency/Action (Kallmann syndrome)

• Kal 1, FGFR1, GNRHR, GPR 54, Lep, SF-1, DAX-1, NELF

• Tumors:

• Benign: Meningioma, Enchondroma

• Cell Rest: Craniopharyngima, Rathke’s Cleft Cyst, Epidermoid, Chordoma, Colloid Cyst, Lipoma

• Germ Cell: Astrocytoma, Dermoid, Dysgerminoma, Ependyoma, Germinoma, Oligodendrogioma, Teratoma

• Metastatic: Breast, Lung, Melanoma, Lymphoma

• Infiltrative: Langerhans Cell (Hand-Schuller-Christian, Eosinophilic Granuloma), Sarcoid

• Infectious: Abscess, TB, Mycoses

• Vascular: Aneurysm, Hemorrhage

• Trauma: Surgery, Irradiation, Chemotherapy