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Aminotransferase Elevations in Healthy Adults
Methods: 145 Adults received 4 gm Acetaminophen alone or in combination with opiates daily for 2 weeks
Incidence of ALT Elevations X 3 vs placebo 31-44%
Incidence of ALT Elevations X 5 vs placebo 19%
Highest ALT Acetaminophen Alone 575
Highest ALT Acetaminophen with Opiates 636
Trough Acetaminophen Levels did not exceed therapeutic levels in any subject
All elevated levels returned to normal after acetaminophen discontinued
(Watkins et al JAMA 2006, 296: 87-93)