Viral Hepatits: E

• Single-stranded RNA (Calicivirus)

• Highest prevalence in Asia, Central America, Africa

• Fecal-oral transmission, 1-2 weeks incubation

• Similar presentation to Hep A

• Fulminant hepatitis 20% mortality during pregnancy

• Serology: Anti IgG or IgM Ab, HEV RNA

• No specific treatment

• Vaccine recently developed (Shreshta et al NEJM 356: 895-903)