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Paradigm for Personalized Research


CGH = comparative genomic hybridization to determine copy number differences.

Full Genome = full genome sequencing.

Many other molecular paramaters such as global or alelle-specific DNA methylation, gene expression levels, and microRNA expression levels can also be considered.

"Informatic analysis" refers to analytic strategies based on sophisticated pattern recognition technology such as support vector machines.

"Skin-derived neurons" refers to subject-specific neurons derived from induced pluripotent stem cells (iPS cells) from skin fibroblasts.

Predictions of the subject-specific theory of illness are tested in therapeutic maneuvers with new or existing drugs, in in vitro studies of subject-specific brain cells, and in molecular studies of relatives.