An R package dfcrm containing functions for the implementation and calibration of the continual reassessment method (CRM) and the time-to-event CRM with for phase I clinical trials can be downloaded from the Comprehensive R Archive Network (CRAN) .

For Windows, the library can be downloaded from within R GUI (version 2.8.1 or later): click Packages/Install package(s), choose a mirror site, and look for dfcrm. For those who have previously installed the R package titecrm, you are strongly encouraged to install dfcrm which is a superset of titecrm and contains much expanded functionality.

The time-to-event continual reassessment method (TITE-CRM) is a fully sequential design that updates our belief about dose-toxicity relationship as we accrue patients during a trial. The dfcrm library also features sensitivity analysis and calibration of a dose-toxicity model in the CRM, coherence of a two-stage CRM, and CRM simulators.

Query regarding the codes, the literature, and the application of the TITE-CRM is most welcome! Click here to contact me.

Last modified: Thu Aug 30 2006 by Ken Cheung