Selected peer-reviewed publications
- Cheung, YK and Klotz, JH (1997).
The Mann Whitney Wilcoxon distribution using linked lists.
Statistica Sinica 7, 805-813.
- Cheung, YK and Chappell, RJ (2000).
Sequential designs for phase I clinical trials with late-onset toxicities.
Biometrics 56, 1177-1182.
- Cheung, YK (2002). On the use of nonparametric curves in phase I trials
with low toxicity tolerance. Biometrics 58, 671-674.
- Cheung, YK (2005). Exact two-sample inference with missing data.
Biometrics 61, 524-531.
- Cheung, YK (2005). Coherence principles in dose-finding studies.
Biometrika 92, 863-873. [
PDF ]
- Cheung, YK, Inoue, LYT, Wathen, JK, and Thall, PF (2006).
Continuous Bayesian adaptive randomization based on event times with
covariates. Stat in Med 25, 55-70.
[
link ]
- Cheung, YK, Gordon, PH, and Levin, B (2006). Selecting promising
ALS therapies in clinical trials. Neurology 67, 1748-1751.
- Cheung, YK (2007). Sequential implementation of stepwise procedures for identifying the maximum
tolerated dose. Journal of the American Statistical Association
102, 1448-1461.
- Cheung, YK (2010). Stochastic approximation and modern model-based
designs for dose-finding clinical trials. Statistical Science
25, 191-201.
[ PDF ]
- Cheung, K and Kaufmann, P (2011). Efficiency perspectives on adaptive designs in
stroke clinical trials. Stroke 42, 2990-2994.
[
Link ]
- Cheung YK (2014). Simple benchmark for complex dose finding studies. Biometrics
70, 389-397. [ Link via
PubMed Central ]
- Cheung K, Duan N (2014). Design of implementation studies for quality improvement programs: an effectiveness-cost-effectiveness
framework. Am J Public Health 104(1), e23-e30. doi: 10.2105/AJPH.2013.301579. Epub 2013 Nov 14.
[ Link via PubMed Central ]
Softwares:
Click here for an R package (dfcrm).
Books
Cheung, YK (2011). Dose Finding by the Continual Reassessment Method.
Chapman & Hall/CRC. [ CRC link ]
[
Amazon Link ]
Take a sample
ERRATA:
Numerical errors in Table 10.3 in Chapter 10 in the printed version. Click
here for a corrected version of Chapter 10 with corrected table
and the corresponding texts.
The abovementioned errors were due to a bug in the function "cohere" in the R package "dfcrm"
with the "logistic" model. The bug has been fixed, and a corrected
dfcrm package (v0.1-5)
is now available on
CRAN. NOTES: The errors were
specifically tied with the use of "logistic" model in "cohere"; the function with "empiric"
model yields correct computations.
Presentations:
Coherence principles in dose-finding studies. ENAR 2007 (March).
Specification of a CRM model. MRC Dose-finding Workshop at Reading University 2010 (March).
Stochastic approximation with virtual observations. ENAR 2011 (March).
Sample size determination under finite patient horizon: potential implications for implementation studies.
NYSPI Biostatistics
Seminar 2012 (April 24). [ abstract ]
CRM calibration and sample size.
Adaptive Designs and Benchmark.
Dose Finding Benchmark. JSM 2014 (August) Boston.
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Last modified: Sat Jul 20 2013 by Ken Cheung