Genetics of developmental disorders

Identify genetic causes of developmental disorders by statistical genetics of rare variants and integration of biological mechanisms.

Genome sequencing

Develop computational and statistical methods for analyzing genome sequencing data and optimizing study design in genetic studies.

Immunogenomics

Computational analysis and mathematical modeling to understand clonal dynamics of immune cells in human under normal conditions and profound perturbation such as organ transplantation or cancer. Experimentally we use TCR sequencing, single cell RNA-Seq and other functional genomics approaches.