Acidification favors increased aggregation
Protonation of G9 PAMAM dendrimers:
ï 2048 outer (primary) amines with pKa ‚ 7-9
ï 2046 inner (tertiary) amines with pKa ‚ 3-6
all within ~ 5 nm radius
_ dramatic changes of charge & H-bonding with pH
pH 3 pH 6 pH 9
Ö control ionic strength of supernatant ?
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