AIN

• Clinical Presentation:

• Fever 27%

• Eosinophilia 23%

• Rash 15

• Triad 10%

• Etiology:

• Drugs 71% :

• NSAIDS*, Beta lactam, Bactrim, Quinolines, Rifampin, Allopurinol, Cimetidine, Indanovir, Omeprazole, Mesalamine, Lasix, Thiazides

• Infections 15%

• Mycobacteria, Rickettsia, Legionella, Leptospira, Syphilis, EBV, CMV, Hantavirus

• Tubulointerstitial Nephritis and Uveitis (TINU) 5%

• Sarcoid 1%

• Diagnosis:

• Eosinophiluria

• Gallium Scan

• Renal Biopsy

• Treatment:

• Stop offending drug/Treat infection

• Steroids

• Mycophenolate

• * NSAIDS: AIN, CIN, Acute Papillary Necrosis, Minimal Change, Membranous, Prernal (Efferent Consriction), Hyponatrenia, Hyperkalemia, HTN