Biochemical Diagnosis: Performance

• Sens Spec

• 24 hr urine:

• VMA 64 95

• Total Metanephrine 77 93

• Fractionated Metanephrines 97 69

• Catecholamines 86 88

• Plasma Metanephrines 99 89

• (+ Liklihood Ratio 5.77/-- Liklihood Ratio .02)*

• Chromogranin A 83 96

• Lenders et al JAMA 2002;287:1427

• * Guller et al Ann Surg 2006;243:102