Pheochromocytoma: Symptoms/Signs “5 Ps”

• Pressure* (HTN) 90%

• Paroxysmal 30%

• Susutained 30%

• Sustained with Paroxysms 30%

• Pain (Headache) 43-80%

• Perspiration 37-71%

• Palpitations 44-71%

• Pallor 42-44%

• Other: Fever, Weight loss, Constipation, Polyuria, Hematuria (Bladder), Episodic Hypotension (Epinephrine-producing ), ST/Atrial fibrillation, Dilated Cardiomyopathy (Piecemeal Necrosis), Hyperglycemia, Erythrocytosis, Leukocytosis

• Other Hormones: ANF, Calcitonin, Coticotropin, GHRH, Opiate peptides, PTHrP, Somatostatin, VIP

• * Orthostatic changes secondary increased GFR and volume contraction