Herpes Simplex: Treatment

• 1st episode (gingivostomatitis)

• • acyclovir 5-10mg/kg IV q8hrs x 7-10 days

• Recurrences

• • valacyclovir 2000mg bid x 1 day

• Genital (1st episode)

• • acyclovir 200mg 5x/day x 10 days
  • valacyclovir 1000mg bid x 7-10 days

• Genital (recurrent)

• • acyclovir 200mg 5x/day x 5 days

• Chronic suppression

• • acyclovir 400mg bid
  • valacyclovir 500mg qd <9/year; 1000mg qd if more