Causes of Diabetes Insipidus

• Central (Neurogenic):

• Idiopathic

• Autoimmune: Lymphocytic Hypohysitis

• Traunatic

• Mailignant: Primary: Craniopharyngioma, Dysgerminoma, meningioma, Glioma, Astrocytoma

• Secondary: Lung, Breast, lymphoma

• Granulomas Sarcoid, Granulomatous hypophysitis, Langerhan’s Cell Histiocytosis

• Infectious: Viral encephalitis, Bacterial Meningitis, Tuberculosis, Fungal

• Vascular: Shehan’s syndrome, Aneuuysm, Hematoma

• Heriditary: Autosomal ADH-neurophysin gene mutations, DIDMOAD (Wolfram’s syndrome) mitochondrial wolframin gene mututaion

• Drugs: ETOH, V2 antagonists

• Nephrogenic:

• Recovery ATN

• Pharmacologic: Lithium, Demeclocine, Methoxyflurane

• Metabolic: Hypokalemia, Hypercalcemia

• Sickle Cell

• Obstructive uropathy

• Myeloma

• Sarcoid

• X-linked V2 receptor mutation

• Vasopressinase: Pregnancy

• Primary Polydipsia:

• Psychogenic

• Dipsogenic: Traumatic, Neurosarcoid, Vasculitis