Causes of Diabetes Insipidus

• Neurogenic:

• Idiopathic

• Autoimmune: Lymphocytic Hypohysitis

• Traumatic

• Malignant:

• Primary: Craniopharyngioma, Dysgerminoma, Meningioma,

• Glioma, Astrocytoma

• Secondary: Lung, Breast, lymphoma

• Granulomas: Sarcoid, Granulomatous hypophysitis, Langerhan’s

• Cell Histiocytosis

• Infectious: Viral encephalitis, Bacterial Meningitis, Tuberculosis,

• Fungal

• Vascular: Sheehan’s syndrome, Aneurysm, Hematoma

• Hereditary: Autosomal ADH- neurophysin gene mutations,

• DIDMOAD (Wolfram’s syndrome) mitochondrial

• wolframin gene mutation

• Drugs: ETOH, V2 antagonists

• Dipsogenic: Traumatic, Neurosarcoid, Vasculitis