Kavli Institute for Brain Science
W3005y/W4005 Neurobiology II: Neural circuits Spring 2015
Lectures: Tu./Th. 4:10-5:25 Room: FAYERWEATHER 310
Course website: https://courseworks.columbia.edu/
Office Hours: Tuesdays and Thursdays from 3-4 pm, 906 NWC building or by appointment Teaching Assistants:
Auditors: allowed only after permission is granted by Professor
REQUIREMENTS: This course is the "capstone" course for the Neurobiology and Behavior undergraduate major at Columbia University and will be taught by the Directors of the Kavli Institute for Brain Science at Columbia. It is designed for advanced undergraduate and graduate students. Knowledge of Cellular Neuroscience (how an action potential is generated and how a synapse works) will be assumed. It is strongly recommended that students take w3004 Neurobiology 1: Molecular and Cellular Neuroscience, or a similar course, before enrolling in w3005. Students unsure about their backgrounds should check a representative syllabus of w3004 in http://www.columbia.edu/cu/biology/courses/w3004/index.html
Required: Kandel et al., Principles of Neural Science, Fifth Edition, McGraw Hill http://www.mhprofessional.com/product.php?isbn=0071390111
During the course we will cover the book, reading most of the chapters. The text is available at the Columbia Bookstore and in also in Book Culture. Several copies should be on reserve at the NWC Science Library.
Also recommended: Kandel, In Search of Memory, Norton. http://books.wwnorton.com/books/In-Search-of-Memory/
Kindle: http://www.amazon.com/Search-Memory-Emergence-Science-Mind- ebook/dp/B002PQ7B5O/ref=tmm_kin_title_0?_encoding=UTF8&sr=&qid=
Papeback: http://www.amazon.com/In-Search-Memory-Emergence- Science/dp/0393329372/ref=tmm_pap_title_0
PAPERS: During the weekly recitations, students will present and discuss papers from the primary literature posted on the course website: https://courseworks.columbia.edu/
EXAMS: Three tests will be given, without a final exam. The first two tests covers material discussed in class. Extra credit will be given for questions related to additional reading of material not covered in class. The last test will also include the research articles discussed in the recitations. The tests take place during class. Rescheduling is only granted under exceptional circumstances, in cases of serious illness or personal crisis, and the student is required to present a letter from the undergraduate dean as well as other supporting evidence (such as doctor’s notes, etc.). Please note all test dates ASAP and make travel arrangements accordingly.
RECITATIONS: Students read and discuss in depth selected research papers posted in the Courseworks website. Weekly attendance at the recitations is mandatory for a passing grade and active participation counts in the final grade. Recitation material will also be part of the third test. Recitations will take place on:
Mondays 5:45-7pm, Fairchild 9000, TBA Tuesdays 5:45-7pm, Fairchild 1000, TBA Wednesdays 5:45-7pm, Fairchild 1000, TBA Thursdays 5:45-7pm, Fairchild 1000, TBA
Graduate students recitation, Thursdays 5:45-7pm, Fairchild 9000, Darcy Kelley
All students need to sign up for one recitation with the corresponding TA and are required to attend that recitation till the end of the semester. The first recitations will be January 26th-29th
GRADING: Each exam will contribute 30% towards the final grade. Participation in the recitations is required for a passing grade and will determine the remaining 10%.
Part I: Introduction
Introduction (Ch. 1- 3) Jan 20th
Neuroscience Laboratory Visit (902 NWC): Peterka Jan 22nd Recitation 1: Jan 26th- 29th: Markram et al 1997
Part II: Cell and Molecular Biology of neurons (Ch. 4-7) Jan 27th
Part III: Synaptic transmission (Ch. 8-14) Jan 29th Recitation 2: Feb 2nd-5th: Sperry 1945
Part VIII: Development
Patterning and differentiation (Ch. 52, 53) Feb 3rd
Axonal growth and Synaptogenesis (Ch. 54, 55) Feb 5th Recitation 3: Feb 9th- 12th Zuo et al 2005
Spinal Cord Development -Jessell Feb 10th
Synaptic refinement and repair (Ch. 56, 57) Feb 12th Recitation 4: Feb 16th- 19th: Wiesel and Hubel 1965
Sexual differentiation and aging (Ch. 58, 59) Feb 17th
Open Q&A Review Feb 19th
No recitations: Feb 23rd- 26th
FIRST TEST Feb 24th
Part V: Perception
The Retina (Ch. 26) Feb 26st
Recitation 5: March 2nd- 5th Hopfield and Tank 1986
Visual Processing (Ch. 25, 27- 29) Mar 3rd
Auditory System (Ch. 30, 31) Mar 5th
Recitation 6: March 9th- 12th Hafting et al 2005
Chemical Senses (Ch. 32) Mar 10th
Somatosensory system and Pain (Ch. 21-24) Mar 12th
SPRING BREAK Mar 17-20th
Recitation 7: March 23rd- 26th Harvey et al 2012 Part VI: Movement
Motor system 1 (Ch. 16, 33-36) Mar 24th
Motor system 2 (Ch. 37 and 38) Mar 26th
Recitation 8: March 30th- April 2nd: Hahnloser et al., 2002
Cerebellum (Ch. 42) Mar 31st
Open Q&A Review April 2nd
No Recitations: April 6th- 9th
SECOND TEST April 7th
Part VII: Information Processing
Emotions and feelings (Ch. 48) April 9th
Recitation 9: April 13th- 16th: Xie et al 2013
Sleep and internal states (Ch. 51) April 14th
Part IX: Language, thought, learning
Learning and memory (Ch. 65-67) April 16th
Recitation 10: April 20-23rd:: Liu et al 2012
Neural Networks (Appendix E, F) April 21st
Memory (Ch. 65-66)-Kandel April 23rd
No Recitations: April 27th-30th
Open Q&A Review April 28th
THIRD TEST April 30th
Markram H, Lubke J, Frotscher M, Sakmann B. (1997) Regulation of synaptic efficacy by coincidence of postsynaptic APs and EPSPs. Science 275:213-5.
Sperry, RW (1945). Restoration of vision after crossing of optic nerves and after contralateral transplantation of eye. J. Physiology, Vol. 8no. 1, 15.
Zuo Y, Yang G, Kwon E, Gan WB. (2005) Long-term sensory deprivation prevents dendritic spine loss in primary somatosensory cortex. Nature 436 :261-5.
Wiesel TN, Hubel DH. (1965). Comparison of the effects of unilateral and bilateral eye closure on cortical unit responses in kittens. J Neurophysiol. Nov;28(6):1029-40.
Hopfield JJ, Tank DW. (1986) Computing with neural circuits: a model. Science 233: 625-33.
Hafting T1, Fyhn M, Molden S, Moser MB, Moser EI. (2005). Microstructure of a spatial map in the entorhinal cortex. Nature Aug 11;436(7052):801-6.
Harvey CD, Coen P, Tank DW. (2012). Choice-specific sequences in parietal cortex during a virtual- navigation decision task. Nature Mar 14;484(7392):62-8
Hahnloser RH, Kozhevnikov AA, Fee MS. (2002) An ultra-sparse code underlies the generation of neural sequences in a songbird. Nature 419:65-70.
Xie L, Kang H, Xu Q, Chen MJ, Liao Y, Thiyagarajan M, O'Donnell J, Christensen DJ, Nicholson C, Iliff JJ, Takano T, Deane R, Nedergaard M.(2013). Sleep drives metabolite clearance from the adult brain. Science. 2013 Oct 18;342(6156):373-7.
Liu X, Ramirez S, Pang PT, Puryear CB, Govindarajan A, Deisseroth K, Tonegawa S. (2012). Optogenetic stimulation of a hippocampal engram activates fear memory recall. Nature Mar 22;484(7394):381-5.