Not offered this academic year  Biology G4054. Mammalian cell genetics. 3.0 pts. L. Chasin. The genetic manipulation of cultured mammalian cells and how such approaches are directed toward problems in cell and molecular biology. Topics include the isolation and exploitation of mutant cells; genome juxtaposition using heterokaryons and hybrids formed by cell fusion; gene transfer and gene isolation by transfection; and homologous recombination. The current and classic literature is studied through a combination of lectures and student presentations.

Not offered this academic year  Biology G4058. Molecular biology of viruses. 4.5 pts. J. L. Manley, C.L. Prives. Current topics in animal virology, with emphasis on viruses that can cause human disease. Mechanisms of viral replication and regulated gene expression are considered in detail. Special emphasis is placed on interactions between viral and cellular gene products. In particular, the roles of viral oncogenes in malignant cell transformation and tumorigenesis, and the structure and replication of HIV (AIDS virus) are major areas of concentration.

Spring 2001 Biology W4065. Molecular biology of disease. 3.0 pts. R. Pollack. Tu 2:10 - 4:00 pm.  Molecular and cellular basis of cystic fibrosis, sickle-cell anemia, retinoblastoma, colorblindness and other diseases examined in discussions based on current literature. Lectures, discussions, and student presentations.  (Undergraduates receive priority for registration.)

Not offered this academic year  Biology G4158. Seminar in nucleic acids and related topics. 2.0 pts. G.L. Zubay. Focuses on a topical area of molecular genetics. Current problems and research in nucleic acids, protein synthesis, mechanisms of regulating the synthesis of macromolecules, and control of genetic activity in chromosomes.

Spring 2001  Biology-Chemistry G4170. Biophysical chemistry. 4.5 pts. A. McDermott. MW 4:15 - 5:30 pm Prerequisite: elementary physical and organic chemistry. Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance; analysis of the conformation of proteins and nucleic acids, hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

Not offered this academic year  Biology G4205. Origins of life. 3.0 pts. G. Zubay.  Recommended one term of biology and one year of chemistry. This course is divided into four areas of study: (1) a brief description of the events that took place from the time of the big bang to the formation of a habitable planet (2) a brief description of the basic strategies of living systems (3) a side-by-side description of how basic chemistry works in living systems and a parallel description of how these systems might have evolved in the prebiotic world and (4) the evolution of living systems

Fall 2000  Biology G4600. Signal transduction. 3pts. D. Kalderon, R. Prywes. Th 40:00pm-6:00pm. In each class, a short introductory lecture provides a summary of past approaches to studying cellular communication, in particular the molecules that act as signals, receptors and effectors, and a summary of the current understanding of major signal transduction mechanisms. In the rest of the class, students present and discuss in detail recent papers and background material concerning aspects of signal transduction of particular current interest.

Spring 2001 Biology W4799 Readings in the molecular biology of cancer. 3.0 pts. L. Yamasaki. TuTh 2:40 - 3:55pm. Prerequisite: three terms of biology (genetics and cell biology recommended). Lectures and discussion. Readings tracing the discovery of the role of DNA tumor viruses in cancerous transformation are discussed. Oncogenes and tumor suppressors are analyzed with respect to their function in normal cell cycle, growth control and human cancers. Registrar's listing.

Spring 2002 Molecular Biophysics G4024Y  Structure and Function of Nucleic Acids. Offered: Spring, Even numbered years.   A.M. Pyle 
Prerequisite: Organic chemistry.  The structure, dynamics, catalytic reactivity and biological function of DNA, RNA, and their derivatives. 4 points 

Spring 2001 Molecular Biophysics G6275Y Diffraction Analysis of Macromolecules. Offered: Spring, Odd numbered years   W. Hendrickson 
Prerequisite: Biophysical Chemistry G4170 or the instructors’ permission. Diffraction theory and applications to protein, nucleic acid, and membrane structures. Topics include electron microscopy, x-ray diffraction, protein crystallography, electron and neutron diffraction and electron microscopy.  4.5 points 

Chemistry C3079x-C3080y Physical chemistry, I and II. 4 pts. MWF 11-11:50.
(The first semester is required for Biology graduate students who have not had Physical Chemistry as undergraduates).

Prerequisites: CHEM C1403-C1404 or C3045-C3046; PHYS C1401-C1402, or the equivalent; MATH V1101-V1102 or V1105-V1106. Recommended parallel: CHEM C3085-C3086.  An elementary but comprehensive treatment of the fundamental laws governing the behavior of individual atoms and molecules and collections of them.
Syllabus for Physical Chemistry C3079x Fall
The physical chemistry course was revised in 1999 to take into account the interests of its students, the great majority of whom are biochemistry majors, biology majors or chemistry majors who are premeds. The text is PHYSICAL CHEMISTRY: Principles and Applications in Biological Sciences. The writing is sparkling with many applications to biology. The authors are three expert biophysical chemists from Berkeley: Tinoco, Sauer and Wang. The Fall semester will be taught by Richard Bersohn and the Spring by Ken Eisenthal.  The course is not a course in biochemistry or even biophysical chemistry. Thermodynamics will be taught in the Fall Semester.  The lectures in the fall semester will be based on the following chapters:
Chapter 1. Introduction
Chapter 2. The First Law: Energy is Conserved.
Chapter 3. The Second Law: The Entropy of the Universe Increases
Chapter 4. Free Energy and Chemical Equilibria
Chapter 7. Kinetics: Rates of Chemical Reactions
Chapter 8. Enzyme Kinetics

Spring 2001 Biology-Chemistry G4170y Biophysical chemistry 4.5 pts. A. McDermott. Lecture: MW 4:15-5:30. or M 7-10 PM
(This course is not a substitute for Physical Chemistry)
Lab: M 7-10 evening. Prerequisite: elementary physical and organic chemistry.
Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance; analysis of the conformation of proteins and nucleic acids; hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure.

Spring 2001  Chemistry G4172. Bio-organic topics. 4.5 pts. R. Breslow.  TR 10:35-11:50am. Prerequisite: introductory organic chemistry. Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosynthesis of natural products and some other bioorganic topics.

Spring 2001  Computer Science W4761. Computational Genomics. 3 pts. W. Grundy. T 4:10-6:40pm Prerequisite: the instructor’s permission. Course will cover the computational methods used to search for, classify, analyze and model DNA, RNA and protein sequences. Course will also look at methods of analysing other kinds of genomics information, such as data obtained from "gene chips". These methods form the core of an important and rapidly growing field of research, known variously as biosequence analysis, bioinformatics or computational molecular biology.

Fall 2000  EESC/ENVB G6110. Evolution, I. 3 pts. R. DeSalle and B. Hahn. T 11:00am-12:50pm. Prerequisites: Priority given to first-year students in EEB or Conservation Biology Certificate program. Lecture course covering principal topics of evolutionary biology from genetics, genome organization, population and quantitative genetics, the history of evolutionary theory, systematics, speciation and species concepts, co-evolution, and biogeography.

Fall 2000  EE-CS-BME. E4060 Introduction to genomic information science and technology. 3 pts. D. Anastassiou. T 6:50-9:20pm.   This course introduces the "information system paradigm" of molecular biology and genetics, in which biomolecular sequences are viewed as elements of digital information systems and recombination and other biomolecular processes are viewed as mathematical operations with simulation and visualization using simple computer programming in MATLAB. All concepts and methods will be introduced. No previous computer or biology background is required for the course.  Note: Does not count toward the 3-elective requirement for Ph.D. students.

Spring 2001  Genetics G4005. Introduction to mathematical genetics. 3 pts. J. Ott. Time TBA  Prerequisite: calculus. Introductory courses in probability are recommended but are not required. Basic concepts of genetics and population genetics. Genetic linkage. Models of disease transmission. While general genetic principles are covered, emphasis is on human genetics and on human genetic linkage.

Not offered this academic year  Genetics G4027. Principles of developmental biology. 3 pts. D. Wolgemuth and staff. Required for first-year Genetics and Development students. Open to students from all departments, but students from outside the Genetics Department should consult the instructor before registering. The course emphasizes the molecular control of vertebrate embryogenesis. Divided into three main areas: early embryogenesis, developmental neurobiology, and the development and differentiation of specialized organs or lineages. A combination of faculty lectures and presentations by participating students.

Fall 2000  Genetics G4050. Advanced eukaryotic molecular genetics. 4 pts. A. Efstratiadis. W 4:00-7:00pm. Required for second year Genetics and Development students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and the instructor’s permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature.

Fall 2000  Genetics G4500. Cellular and molecular biology of cancer. 3pts. B. Tycko. W 5:00pm-7:00pm. Required for students on the cancer training grant. Open to all students. An integrated and critical review of cancer biology, emphasizing recent research. Topics discussed include: natural history and epidemiology of cancer; morphology and behavior of cancer cells; DNA and RNA tumor viruses; oncogenes; tumor suppressor genes; signal transduction; the genetics of cancer; cancer and cellular differentiation; cancer causation: physical and chemical agents; multistage carcinogenesis; hormones, nutrients, and growth factors in cancer. Readings are largely original research papers and review articles. One 2-hour seminar per week. Note: Does not count toward the 3-elective requirement for Ph.D. students.

Spring 2001  Microbiology G4020. Introduction to immunology. 4 pts. P.B. Rothman and staff.  TR 2:00-3:00pm. Survey of the major topics in basic immunology with an emphasis on the molecular basis for immune recognition and regulation.

Not offered this academic year  Microbiology G6050. Advanced microbiology. 2-6 pts. V. Racaniello and members of the staff. Prerequisite: the instructor’s permission. This course is intended as an introduction to microbiology for graduate students, and will serve as a prerequisite to Advanced topics in microbiology. Topics to be covered will include virology (fundamental properties of virus replication, the molecular biology of viral replication and pathogenesis), immunology (the humoral and cellular immune response and its molecular basis), and the study of yeast (recombination and control of gene expression). There will be two lectures per week and one discussion section in which scientific papers will be analyzed.

Fall 2000  Pathology G6003. Molecular and cellular mechanics in human disease. 3 pts. R. Liem and members of the staff. Time TBA. Open only to graduate students in the basic and medical science departments. Prerequisite: cofitter release. 3 pts. C. Bailey, D. Goldberg, A. MacDermott. Time TBA.  Prerequisite: a neural science course and the instructor’s permission. A detailed examination of the cellular and molecular processes influencing synaptic transmission.

Spring 2000  Physiology G4500. Advanced topics in immunology.  4 pts.  C. Schindler.  Time TBA.

Not offered this academic year  Psychology G4490. Pathophysiology of psychiatric disorders. 3 pts. J. Horvitz. Prerequisite: Instructor's approval. Fundamental psychological dysfunction, animal models, and neurochemical disturbances associated with schizophrenia. Note: Does not count toward the 3-elective requirement for Ph.D. student

Fall 2000 / Spring 2001  Statistics - IEOR W4150. Introduction to probability and statistics. 3 pts. C. Heyde. TuTh 4:10pm-5:25pm / Spring time TBA Prerequisite: a working knowledge of calculus. Fundamentals of probability theory and statistical inference. Probabilistic models, random variable, useful distributions, expectations, laws of large numbers, central limit theorem. Statistical inference: point and confidence interval estimation, hypothesis tests, linear regression.  Note: Does not count toward the 3-elective requirement for Ph.D. students; does count toward the 3-semester undergraduate math requirement

Fall 2000 / Spring 2001 Statistics W1001x or y Introduction To Statistical Reasoning 3.00 pts. Prerequisite: some high school algebra. Friendly introduction emphasizing conceptual understanding and applications. Topics include design of experiments, data collection and graphical display, probability and modeling, normal curve and its approximations, linear regression, confidence intervals, hypothesis testing, computer use for data management. Examples drawn from several areas, including medical studies, genetics, political science, population surveys, economics, legal studies, business, and physics. (SC) Note: Does not count toward the 3-elective requirement for Ph.D. students; does count toward the 3- semester undergraduate math requirement