Courses for Biotechnology MA Students

Updated November 24, 2009

Here is a list of required and pre-approved elective courses. Even though our program will accept the courses in the list, it does not mean that you automatically qualify to take them. Check with the professor and the department offering the courses to see if you meet the pre-requisites set forth by them. Courses availability and time are tentative and will be updated as information becomes available. Always check Directory of Classes for official listing of actual offering time and location.

Elective Keys

Core Biotechnology Courses (Required, 9 points)

v	F	BIOL W4034	3	MW 4:10-5:25	Biotechnology. D. Kalderon Prerequisite: genetics or molecular biology. Techniques currently used to explore and manipulate gene function. Topics include characterization of biochemical activities of gene products in vitro and in heterologous cells, and investigation of gene function in model genetic organisms and in humans. Study of human genetic disease is emphasized. web site
v	F	BIOL W4300	3	MW 2:40-3:55	Drugs and Disease. C. Lin The molecular basis of human diseases will be discussed with an emphasis on novel therapeutic approaches. The course will include a combination of lectures and discussion or original research articles. Prerequisites: Four semesters of biology including a foundation in molecular and cellular biology. web site
v	Sp	BIOL G4305	3	W 4:10-6	Seminar in Biotechnology. C. Lin A weekly seminar and discussion course focusing on the most recent development in biotechnology. Professionals of the pharmaceutical, biotechnology and related industries will be invited to present and lead discussions. Prerequisites: W4300 web site

Laboratory (minimum 6 points)

v	F	BIOL G4260	3	R 9:10-12:15	Proteomics Laboratory. L. Brown Plus additional lab works. Prerequisites: Instructor's permission. Fee: $150. Open to students in M.A. in Biotechnology Program (points can be counted against laboratory requirement for that program), Ph.D. and advanced undergraduate students with background in genetics or molecular biology. Students should be comfortable with basic biotechnology laboratory techniques as well as being interested in doing computational work in a Windows environment. This course deals with the proteome: the expressed protein complement of a cell, matrix, tissue, organ or organism. The study of the proteome (proteomics) is broadly applicable to life sciences research, and is increasing important in academic, government and industrial research through extension of the impact of advances in genomics. These techniques are being applied to basic research, exploratory studies of cancer and other diseases, drug discovery and many other topics. Techniques of protein extraction, two-dimensional gel electrophoresis and mass spectrometry will be covered. Emphasis will be on mastery of practical techniques of MALDI-TOF mass spectrometry and database searching for identification of proteins separated by gel electrophoresis as well as background tutorials and exercises covering other techniques used in descriptive and comparative proteomics. web site
v	Su	BIOL G4310	6	MTWR 9-2	Intensive Laboratory in Biotechnology. C. Lin Intense laboratory exercise where students meet 4 days a week for eight weeks participating in experimental design, bench work, and data analysis. Grades depend on participation in the laboratory, reports, and practical exams. Class starts immediately following Spring final exams. web site
v v	F Sp Su	BIOL G4500 G4501 S4502 S4503	2-6		Supervised Research. C. Lin Students conduct research related to biotechnology under the sponsorship of a mentor within or outside the University. Credits received from this course may be used to fulfill the laboratory requirement for the degree. Students may work on a significant research problem related to their professional needs. The student and the mentor determine the nature and extent of this independent study. In some laboratories, the student may be assigned to work with a postdoctoral fellow, graduate student or a senior member of the laboratory, who is in turn supervised by the mentor. The mentor is responsible for mentoring and evaluating the student’s progress and performance. web site
v	Sp	CHEN E4760	3	R 1:30-4:30	Genomics Sequencing Laboratory. J. Ju Prerequisites: Undergraduate level biology, organic chemistry and instructor's permission. The chemical, biological and engineering principles involved in the genomics sequencing process will be illustrated throughout the course for engineering students to develop the hands-on skills in conducting genomics research.
v	F	BMEN E6500	4	T 1:10-5:30	Tissue and Molecular Engineering Laboratory. H. Huang Hands on experiment in molecular and cellular techniques, including fabrication of living engineered tissues. Covers sterile technique, culture of mammalian cells, microscopy, basic subcloning and gel electrophoresis, creation of cell-seeded scaffolds, and the effects of mechanical loading on the metabolism of living cells or tissues. preliminary syllabus

Electives (minimum 15 points)
At least 9 points must be from category A (►). No more than 6 points from category B (■) can be used to fulfill degree requirements.

Biological Sciences (bulletin listing)

v	F	►	BIOL W4004	4	TR 4:10-5:25	Cellular and Molecular Neurobiology. S.J. Firestein Recitation: hours to be arranged. Prerequisite: one year of biology, and a course in physics is highly recommended. An introduction to the cellular and molecular aspects of nerve cell function. Topics include the cell biology and biochemistry of nerve cells, ionic and molecular bases of electrical signals, synaptic transmission and its modulation, and sensory receptors. Recitation emphasizes readings from the primary literature. website
v	Sp	►	BIOL W4005	4	TR 4:10-5:25	Systems Neurobiology. D. Kelley Recitation: hours to be arranged. Prerequisite: one year of biology or instructor's permission. An introduction to the development and properties of ensembles of neurons, particularly the vertebrate central nervous system (CNS). Topics include CNS organization and development, parallel and serial processing in sensory and motor systems, modulation of neural activity by hormones and neurotransmitters, and neuroethology. Major emphasis is placed on readings from the primary literature. web site
v	Sp	►	BIOL W4008	3	TR 4:10-5:25	The Cellular Physiology of Disease. J. Fernandez This course will present a quantitative description of the cellular physiology of excitable cells (mostly nerve and muscle). While the course will focus on examining basic mechanisms in cell physiology, there will be a thread of discussion of disease mechanisms throughout. The end of each lecture will include a discussion of the molecular mechanisms of selected diseases that relate to the topics covered in the lecture. The course will consist of two lectures per week. This course will be of interest to advanced (3000-4000 level) undergraduates that aim to pursue careers in medicine as well as those that will pursue careers in biomedical research. This course will also be of interest to graduate students desiring an introduction to the cellular physiology of nerve and muscle. web site
v	F	►	BIOL G4008	3	W 12-2	Advanced Seminar in Neurobiology. S. J. Firestein, D. Zou Sensory systems provide a window on the brain. From the primary events of signal transduction to the organization of receptive fields and higher order processing, the senses utilize mechanisms that are shared by all neural systems. This seminar stresses the general principles of signalling and the common neurobiological motifs typified in sensory systems. Results emerging from biophysical, molecular, physiological, and computational approaches are treated, utilizing both the current literature and classic papers in the field. Offered every other years.
v	F	►	BIOL W4011	3	F 9- 11	Neural System - Circuits in the Brain. R. Yuste This course will review current knowledge about the computation carried out by different microcircuits in the mammalian CNS. The levels of analysis covered by the course will span channel behavior, synaptic physiology, dendritic integration, neuro anatomy, and circuit studies. Web site
v	F	►	BIOL W4022	3	TR 1:10-2:25	Developmental Biology. A. Heicklen Prerequisites: BIOL C2005-C2006 or equivalent An introduction to developmental biology stressing the molecular mechanisms controlling development. Topics include sex determination, imprinting, X-chromosome inactivation, gametogenesis, stem cells, cloning, fertilization, the Pill, early development, and aging. web site
v	Sp	►	BIOL W4031	3	MW 6:10-7:25	Genetics. Y. Lim, B. Perez Optional one-hour problem session to be arranged. Prerequisite: BIOL C2005-C2006 or the equivalent. Recommended requisite: one term of organic chemistry. A general course in genetics dealing with principles of gene structure, function, and transmission. The historical development and experimental basis of current knowledge are stressed. web site
v	Sp	►	BIOL G4035	3	T 2:10-4:00	Seminar in Epigenetics. S. Jia This is a combined lecture/seminar course designed for advanced undergraduates and graduate students. The focus is on understanding the mechanisms underlying epigenetic phenomena: he heritable inheritance of genetic states without change in DNA sequence. Epigenetic mechanisms play important roles during normal animal development and oncogenesis. It is an area under intensive scientific investigation and the course will focus on recent advances in understanding these phenomena. In each class, students will present and discuss in detail recent papers and background material concerning each individual topic, followed by an introductory lecture on the following week’s topic. This course will emphasize critical analysis of the scientific literature and help students understand how to identify important biological problems and how to address them experimentally. Prerequisites: Genetics or Molecular Biology, and the permission of the instructor.
v	F	►	BIOL W4041	3	TR 10:35-11:50	Cell Biology. E. Miller Prerequisite: one year of biology, normally BIOL C2005-C2006, or the equivalent. Recommended preparation or core requisite: organic chemistry and rudimentary physics. An introduction to cell biology stressing the relations of cell structure to physiology, biochemistry, and heredity, and the experimental and observational basis of current views of the cell. web site
v	F	►	BIOL G4044	3	R 4:10-6	Advanced Topics in Cell Biology. J. Bulinski Advanced Topics in Cell Biology is a graduate course, primarily enrolling Ph.D. students, but also enrolling advanced M.A. students and undergraduates with consent of one of the instructors. This year’s offering will concentrate on the basic cell biology of signal transduction and its readouts within the cytoskeleton and its activities inside the cell. Students will read the literature and give presentations. Topics include the pathways by which cells respond to extracellular signals such as growth factors and cell-cell contact, and the mechanisms by which extracellular signals are translated into alterations in the cell cycle, morphology, differentiation state, and motility of the responding cells. web site
	F	►	BIOL G4045	3	W 4:10-6	Seminar in Cell Biology. E. Miller Prerequisites: Cell Biology (3041/4041) and the permission of the instructor. This is a combined lecture/seminar course designed for advanced undergraduates and graduate students. The focus is on understanding how infectious microbes manipulate host cell processes to multiply and evade immune detection. In each class, an introductory lecture will provide a summary of the biology of the organism under discussion and historical findings that have improved our understanding of host/pathogen interactions. Students will then present and discuss in detail recent papers and background material concerning specific aspects of microbial infection and the host response. web site
	F	►	BIOL W4070	3	W 4:10-7	Biology and Physics of Single Molecules. M. Sheetz, J. Fernandez This course will examine the fundamental mechanisms underlying the behavior of biological molecules, at the single molecule level. The course will cover the methods used to track single molecules: optical tweezers, single molecule AFM, Magnetic tweezers, Optical techniques and Fluorescence energy transfer (FRET) probes. The course will cover the mechanism of action of mechanical motors such as myosin dyneyin, kinesin. It will cover the action of DNA binding enzymes such as topoisomerases, helicases, etc. We will also discuss the function of large motors such as the ATP Synthase and the bacterial AAA ATPases. We will discuss the mechanical properties of DNA, RNA, and proteins. The course will consist mainly of reviewing classical experiments in each category, and developing the background physical theories to promote a deep understanding of biological mechanisms at the mesoscopic level. web site
v v	F Sp	► ►	BIOL W4073	3	MW 10:35-11:50	Cellular and Molecular Immunology. S. Mowshowitz Prerequisite: three terms of biology. An introduction to immunology with special emphasis on the development and activation of lymphocytes and the role of cytokines in immunoregulation. web site
v	F	►	BIOL G4095	2	TR 2:40-3:55	Chemical Genomics. B. Stockwell First half of semester (September - mid October). In this course, we will cover subject matter in chemical biology and genomics. We will discuss approaches for discovering and optimizing chemical tools for measuring and perturbing biological systems. Topics covered will include high-throughput assay development, chemical and genomic screening, chemical library creation, high-throughput chemistry, affinity purification of target proteins and target validation, protein microarrays and the druggable genome. The course is intended to provide a foundation needed for advanced chemical biology and genomic research, i.e. the creation and use of chemical and genomic probes of biological processes. The course will be of interest to students at the interface between chemistry and biology, and students interested in medicine, academic chemical biology and drug discovery efforts. Prerequisites: One year of college-level biology and one year of organic chemistry, or the instructor's permission. Advanced undergraduate students are encouraged to enroll, and they will be given extra assistance in preparing the research proposal (no prior experience in writing proposals is needed).
	Sp	■	BIOT G4140	3		Fundamentals of the Bioscience Industry. C. Lin For those enrolled in the Industry Certificate Program. web site
		►	BIOL W4150	3	MW 4-5:20	Biology The Cell as a Machine: Cell Biophysics and Biosystems Engineering. M. Sheetz Focuses on a topical area of molecular genetics. Current problems and research in nucleic acids, protein synthesis, mechanisms of regulating the synthesis of macromolecules, and control of genetic activity in chromosomes. All potential participants must show up on the first day as that is when we organize the topics and seminar assignments. Each student is to give a seminar on a particular aspect of this subject. web site
v	Sp	►	BIOC G4170	4.5	TF 4:15-5:30	Biophysical Chemistry. A. McDermott, A. Cacciuto Prerequisite: elementary physical and organic chemistry. Recommended preparation: elementary biochemistry. Tactics and techniques for the study of large molecules of biological importance; analysis of the conformation of proteins and nucleic acids, hydrodynamic, scattering, and spectroscopic techniques for examining macromolecular structure Includes laboratory exercises in molecular computer graphics and in structural biological and chemical informatics.
v	F	■	BIOT W4200	3	R 3:40-5:40	Biopharmaceutical Development and Regulation. R. Guido The course aims to provide current life sciences students with an understanding of what drives the regulatory strategies that surround the development decision making process, and how the regulatory professional may best contribute to the goals of product development and approval. To effect this we will examine operational, strategic and commercial aspects of the regulatory approval process for new drug, biologic and biotechnology products both in the United States and worldwide. The topics are designed to provide a chronological review of the requirements needed to obtain marketing approval. Regulatory strategic, operational, and marketing considerations will be addressed throughout the course. We will examine and analyze the regulatory process as a product candidates are advanced from Research and Development, through pre-clinical and clinical testing, to marketing approval, product launch and the post-marketing phase. The goal of this course is to introduce and familiarize students with the terminology, timelines and actual steps followed by Regulatory Affairs professionals employed in the pharmaceutical or biotechnology industry. Worked examples will be explored to illustrate complex topics and illustrate interpretation of regulations. web site
v	Sp	►	BIOL W4400	4	TR 1:10-2:25	Biological Networks. D. Pe'Er The course will start with an introduction to types of biological networks and many of the new high throughput and quantitative technologies now available. We will start with the mathematical and computational analysis of small networks in order to understand some of the basic principles in biological networks including network motifs, modularity, robustness and stochasticity. The course will then scale up to much larger networks teaching the computation techniques needed to address these including Hidden Markov Models, Bayesian networks, FDR, Bootstrapping, Expectation Maximization, Inference, Gibbs Sampling, Monte Carlo and Belief Propagation. We cover many of the pitfalls of high throughput data and how to over come these, proper modeling choices when building large scale models of molecular networks and how to apply the techniques learned to real data. We will learn how to reconstruct regulatory networks from such data and understand how these networks compute, dynamically change and the connections between genetic sequence and these molecular regulatory networks. Finally will demonstrate how the Bayesian techniques learned in the course can be applied to other biological networks such as a network of interacting neurons.
v	F	►	BIOC W4501	4	TR 2:40-3:55	Biochemistry I: Structure and Metabolism. B. Stockwell Recitation: one hour to be arranged. Students wishing to cover the full range of modern biochemistry should take both BIOC W4501 and W4512. Prerequisites: BIOL W2001 or C2005 and one year of organic chemistry. Protein structure, protein folding, enzyme kinetics, allostery, membrane transport, biological membranes, and protein targeting. Chemistry and metabolism of amino acids, carbohydrates, lipids, purines, and pyrimidines. Not for students taking or have taken Biochemistry G4021 web site
v	F	►	CHBC W4510	4	TR 1:10-2:25	Molecular Systems Biology I. H. Bussemaker, J. Hunt Prerequisites: One year of Biology and one year of Chemistry (AP in High School and/or at Columbia) or permission from the instructor. This year-long, four-credits per semester, course will present a quantitative description of the molecular networks that underlie the myriad phenotypes in living cells. Topics covered include various high-throughput technologies (genome sequencing, DNA microarrays, proteomics, and phenotypic drug screening), transcriptional and post-transcriptional regulatory networks, synthetic biology, and neural networks. These will be integrated with introductory lectures on molecular and structural biology, thermodynamics, statistics, and machine learning. This course will be of interest to advanced undergraduates as well as beginning graduate students in Biology, Chemistry, Physics, Engineering, and Computer Science. It is unapologetically quantitative, interdisciplinary, and rooted in the latest research areas with a soft focus on cancer. The course is taught by research scientists active in the various areas that integrate systems biology: from detecting and manipulating single molecules all the way up to the computational synthesis of molecular networks. In addition to the lectures on Tuesdays and Thursdays there will be weekly tutorials designed to clarify the material of the lectures. web site
	Sp	►	CHBC W4511	4	TR 1:10-2:25	Molecular Systems Biology II. R. Gonzalez See above.
v	Sp	►	BIOC W4512	3	MW 2:40-3:55	Molecular Biology. R. Prywes, S. Jia Prerequisites: one year of biology and one year of organic chemistry. Recommended but not required: BIOC W4501. Nucleic acid structure and enzymology; DNA replication, DNA repair, and transcription; RNA processing and translation; biochemical approach to the study of gene expression and regulation, with emphasis on the diseases caused when these basic processes are altered. Not for students taking or have taken Biochemistry G4026 web site
v	Sp	►	BIOL G4700	3	F 12:00-2:00	Seminars in Stem Cell Biology. D. Kalderon, J. Bulinski, C. Hung, G. Vunjak-Novakovic Instructor's permission required. Roughly alternating weeks of high-level research seminars from guest speakers and class discussions will cover selected topics at the forefront of stem cell biology research in a course designed for PhD and advanced Masters' students. Grading based on class participation, written assignments every other week and a term paper with an original synthesis of ideas or a research proposal. web site
v	Sp	►	BIOL W4799	3	TR 2:40-3:55	Molecular Biology of Cancer. C. Prives Prerequisite: three terms of biology (genetics and cell biology recommended). Lectures and discussion. Readings tracing the discovery of the role of DNA tumor viruses in cancerous transformation are discussed. Oncogenes and tumor suppressors are analyzed with respect to their function in normal cell cycle, growth control and human cancers. web site
v	F	►	BIOL G6002	2	MW 10:35-11:50	Protein Thermodynamics. J. Hunt Second half of semester (starting mid- to late October.) Prerequisites: College-level general chemistry plus an introductory course in molecular biology or biochemistry. This course presents a rigorous introduction to solution thermodynamics and applies it to understanding the structural and functional features of proteins. After exploring the conceptual origins of thermodynamic theory, the standard equations describing solution equilibria are derived and applied to analyzing biochemical reactions, with a focus on those involved in protein folding and allosteric communication. The semester culminates with exploration of the energetic factors controlling the formation of protein secondary structures and the role of entropy-enthalpy compensation in determining the complex temperature-dependent thermodynamic properties of aqueous solutions. The course emphasizes both qualitative understanding of the thermodynamic forces controlling the evolution and function of living organisms as well as practical application of thermodynamic methods and structural insight in laboratory research. Tutorials cover the use of curve-fitting techniques to analyze biochemical equilibria as well as the use of molecular visualization software to understand protein structure and function.

Biochemistry and Molecular Biophysics (bulletin listing)

v	F	►	BCHM G4021	3	T 7:10-9	General Biochemistry. A. I. Krasna Primarily for students in departments other than biochemistry. Prerequisite: general and organic chemistry. An integration, from a dynamic point of view, of cellular constituents with the chemical processes of living systems: chemistry and function, mode of synthesis and degradation by the cell, the characterization and role of particular enzymes and coenzymes in these reactions, and the mechanisms of oxidation and energy production. Nucleic acids, replication, and the genetic code. (Given at the Morningside campus.) Not for students taking or have taken BiologymC3501. Instructor's approval required.
v	Sp	►	BCHM G4026	3	R 7:10-9	Biochemistry of Nucleic and Protein Synthesis. P. R. Srinivasan Prerequisite: A basic course in biochemistry or biology or permission of the instructor. Structure and organization of chromatin, nucleic acid hybridization and sequence complexity of DNA, DNA and RNA sequencing methods, current views of replication and repair, transcription and translation, regulation of nucleic acid and protein syntheses, recombinant DNA techniques, gene transfer, and gene duplication. Evaluation of original papers, experimental procedures and conclusions. (Given at the Morningside campus.) Not for students taking or have taken Biology W4512.
v	F	►	BCHM G4250	4.5	MWF 4-5:30	Molecular Biophysics. B. Honig Methods and principles involved in studying the structure and function of proteins, nucleic acids, membranes and their macromolecular assemblies. Noncovalent forces and conformational analysis; ultracentrifugation, viscometry, circular dichroism, fluorescence, magnetic resonance, conformational changes in proteins and nucleic acids, topological properties of macromolecules. Prerequisite: Basic physical and organic chemistry and the instructor’s permission.
	Sp	►	BCHM G6045	3	T 4-6	Membrane Receptor/Transport Proteins. A. Karlin Molecular structure and function of membrane proteins; general principles and common threads. Prerequisites and instructor's approval required.
	Sp	►	BCHM G6275	4.5	MWF 4-5:30	Diffraction Analysis of Macromolecules. W. Hendrickson Prerequisite: Biophysical Chemistry G4170 or the instructors’ permission. Content: Diffraction theory and applications to protein, nucleic acid, and membrane structures. Topics include electron microscopy, x-ray diffraction, protein crystallography, electron and neutron diffraction and electron microscopy.
v	F	►	BCHM G6300	4.5	MWF 2-4	Biochemistry/Molecular Biology I. L. Shapiro, E. Greene
	Sp	►	BCHM G6301	4.5	MWF 2-3:30	Biochemistry/Molecular Biology II. G. Gunderson

Biomedical Engineering (bulletin listing)

v	Sp	■	BMEN E4010	2	W 2:40-3:55	Ethics for Biomedical Engineers. J. Loike Prerequisite: senior status in biomedical engineering or the instructor's permission. Covers a wide range of issues expected to confront graduates as they enter the biotechnology industry, research, or medical careers. Ethical issues raised by animal research, experimental drugs and treatments, record keeping in research and medicine, authorship of publications, conflicts of interest, identification and reporting of scientific misconduct. Presentation of student-selected topics will occupy the second half of the course.
	Sp	►	BMEN E4340	3	W 4:10-6:55	Biomechanics of Cells. C. Jacobs
v	F	►	BMEN E4501	3	MW 11-12:15	Tissue Engineering I. H. Lu An introduction to the strategies and fundamental bioengineering design criteria in the development of biomaterials and tissue engineered grafts. Material structural-functional relationships, biocompatibility in terms of material and host responses. Through discussions, readings, and a group design project, students acquire an understand of cell-material interactions and identify the parameters critical in the design and selection of biomaterials for biomedical applications.
v	Sp	►	BMEN E4502	3	MW 11-12:15	Tissue Engineering II. C. Hung

Biomedical Informatics (bulletin listing)

	Sp	►	BINF G4013	3	R 9-12	Biological Sequence Analysis. R. Friedman This course is the same as course CMBS G4020, except that a final exam is required. Letter grade. The course covers PC operation, basic Unix, web-site usage, sequence comparison, database searching, multiple sequence alignment, profile methods, secondary structure prediction, mapping, primer design, and genomic analysis. web site
	Sp	►	BINF G4014	3	MR 11-12:30	Computational Biology. A. Rzhetsky

Biostatistics (bulletin listing)

	F	■	BIST P6100	1	MW 5:30-8	Introduction to Vital Statistics. M. Pavlicova Mass data of the health fields; the content of vital statistics; methods of collecting, tabulating, and graphing population data; A discussion of vital indices and the distinction between crude, specific and adjusted rates. Direct standardization. Life Table Analysis.
v	F	►	BIST P6103	3	TR 12:00-1:20	Introduction to Biostatistics. TBA This course covers the language of biostatistics and the standard techniques of data collection and analysis. It is designed as a first semester course and includes topics discussed in Public Health P6100. The inferential topics include the Normal distribution, measures of central tendency and dispersion, hypothesis testing, confidence intervals, regression and correlation. Placement exam required before registration.

Business School Courses Limited availability (Cross Registration) (Cross registration approval required at the Biotech program office).

v	F Sp	■	FINC B6302	3		Capital Markets and Investments. Donaldson or Zurack NOTE: This course is required for enrollment in all upper-level finance courses (8300 and 9300) and must be taken prior to or concurrently with any upper-level finance course. It is not required for upper-level economics courses (8200 and 9200). This course complements B6301(a core course) by introducing market and portfolio perspectives. The course starts with the discounted cash flow methodology, which ends B6301, and continues to the concept of term structure in the valuation of risk-free cash flows, including forward rates. Next, the general problem of valuing risky or uncertain cash flows is considered. This leads to the classical theoretical problems of portfolio diversification, the efficient frontier and two-fund separation. The capital asset pricing model (CAPM), arbitrage pricing theory (APT) and efficient market theory are explained. The Modigliani-Miller theory is presented as corporate-perspective application of asset valuation ideas. Rounding out the course is an introduction to the valuation of derivatives using binomial trees.
v	Sp	■	BUEC B8299 -002	1.5	TR 2:15-3:45	Economics of Health Care & Pharmaceuticals. F. Lichtenberg This course provides a basic overview of the health care industry that emphasizes the economic issues that affect medical care delivery and finance. It considers the efficiency of alternative health care delivery systems; analyzes incentives and organizational structure of the health care system; and assesses the roles of physicians, hospitals, pharmaceutical and device manufacturers, and HMOs and other contractual networks.
v	Sp	■	MGMT B8799 -017	1.5	MW 12:30-2	Strategy and Competition in Pharmaceuticals and Biotechnology. C. Cramer This course examines the strategic, technology, competitive, organizational and political challenges impacting the global pharmaceuticals and biotechnology sector. Critical issues examined include: the strategies and process of discovering, developing, and getting new drugs approved; the impact of government oversight and regulation; R&D/product portfolio strategies; patent strategies and challenges; the design of prescription drug plans and role of PBMS; competition between branded, generic and OTC products; industry and growth prospects; restructuring strategies to address slowing top-line growth; external/ business developing strategies; related legislative and health policy initiatives; and unique challenges of managing early-stage biotechnology companies.
	Sp	■	FINC B9399 -03	1.5	TR 2:15-3:45	Healthcare Investment and Dealmaking. C. Cramer This course analyzes the unique characteristics and strategies in the health care sector from the perspective of venture capital firms investing in early-stage health care enterprises, private equity firms seeking to build value-creating health care platforms, and entrepreneurs seeking capital from these and other sources. The course addresses how to source attractive investment opportunities in a health care system which is costly, fragmented and inefficient; how investors can assess, value and manage the inherent risks in investing in a highly regulated and politically-charged environment; the unique challenges of healthcare entrepreneurs in building a management team and developing and financing research & commercial infrastructure; and in-depth business development and "dealmaking" strategies (partnering, licensing and M&A) pursued by health care companies to enhance completive position.
	F	■	MRKT B9601	1.5	M 12:30-2	Health Care Marketing. M. Wosinska This course covers marketing strategies for health care players, with an emphasis on pharmaceutical, biotechnology and medical device companies. It will focus on the environment and market dynamics that can have a significant impact on the success of these marketing strategies. Some of the issues addressed in this course include: how to acquire and retain new patients; new product introduction and adoption; challenges and opportunities of value pricing; how marketing fits in early products development; how regulation and market structure affects availability of physician and consumer data; customer segmentation strategies, effective use of advertising and public relations; information and market research; and sale force design and management.
	F	■	MRKT B9601 -051	3	M 2:15-5:30	Seminar in Marketing; High Tech Marktng/Entreprnrshp. R. Kivetz
	F	■	MRKT B9601 -052	3	MW 12:30-2	Seminar in Marketing; Healthcare Marketing. J. P. Benya
v	F	■	MRKT B8699	1.5		Entrepreneurial Selling. Baron
v	F	■	OPMN B9811	3	TR 4:00-5:30	Healthcare Industry in the 21st Century. L. Green This course provides an overview of the health care industry, the major players involved in the payment, production, and delivery of health care and the key challenges and opportunities facing health care executives, investors and policymakers. Topics include strategies for addressing costs, quality and access, and the perspectives of consumers/patients, payers, providers/caregivers, and producers/suppliers. Emphasis is placed on challenges and opportunities afforded by new legislation, information technology, and new methods of health care delivery and payment. Though the focus is primarily on the U.S., comparison with health care systems in other countries is also discussed.

Cellular, Molecular, and Biophysical Studies (bulletin listing)

v	Sp	■	CMBS G4010	1		Responsible Conduct of Research and Related Policy Issues. R. Kessin, J. Rubin This course explores a variety of ethical and policy issues that arise during the conduct of basic and clinical scientific research. Course sessions include lectures, discussion periods, and analyses of case studies.
v	Sp	■	CMBS G4020	3	R 9-12	Biological Sequence Analysis. R. Friedman This course is the same as course BINF G4013, except that a final exam is not required. P/F grade only. The course covers PC operation, basic Unix, web-site usage, sequence comparison, database searching, multiple sequence alignment, profile methods, secondary structure prediction, mapping, primer design, and genomic analysis. web site
	F	►	CMBS G4150	4	MWF 10-12	Microbial Molecular Genetics. F. Chang Prerequisite: basic biology and biochemistry; the instructor’s permission. Basic aspects of prokaryotic molecular biology and genetics. Regulation of gene expression, molecular genetics of bacterial viruses, plasmids and transposable elements. Modern molecular genetic approaches to complex biological phenomena. Format: four to five hours of lecture and discussion per week. Instructor's approval required.
	Sp	►	CMBS G4350	4	MWF 10-11:30	Cellular Membrane and Organelle. G. Gundersen Introduction of eukaryotic cell biology; discussion of modern research approaches and current literature. Format: 3 hours of lecture and 1 hour of student presentation per week.

Chemical Engineering (bulletin listing)

v	F	■	CHEN E4020	3	M 6:10-8:40	Safeguarding Intellectual and Business Property. R. Pearlman
v	F	►	CHEN E4700	3	M 6:10-8:40	Principles of Genomic Technology. J. Ju Chemical and physical aspects of genome structure and organization, genetic information flow from DNA to RNA to Protein. Nucleic acid hybridizationand sequence complexity of DNA and RNA. Genome mapping and sequencing methods. The engineering of DNA polymerase for DNA sequencing and polymerase chain reaction. Fluorescent DNA sequencing and high-throughput DNA sequence development. Construction of gene chip and microarray for gene expression analysis. Technology and biochemical approach for functional genomicsanalysis. Gene discovery and genetics database search method. The application of genetic database for new therapeutics discovery. Department's approval required.

Chemistry (bulletin listing)

v	Sp	►	BIOC G4170	4.5	TF 4:15-5:30	Biophysical Chemistry. R. Gonzalez, A. Cacciuto, A. McDermott Includes laboratory exercises in molecular computer graphics and in structural biological and chemical informatics. web site
v	Sp	►	CHEM G4172	4.5	TR 10:35-11:50	Bio-organic Topics. R. Breslow, N. Berova Prerequisite: introductory organic chemistry. Recommended preparation: advanced organic chemistry. Various topics in bioactive molecules in the field centered on natural-products chemistry, metabolic transformations, and enzyme mechanisms. Biosynthesis of natural products and some other bioorganic topics.

Computer Science (bulletin listing)

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CBMF
W4761

MW
2:40-3:55

Computational Genomics. I. Pe'er
Prerequisite: the instructor’s permission. Course will cover the computational methods used to search for, classify, analyze and model DNA, RNA and protein sequences. Course will also look at methods of analyzing other kinds of genomics information, such as data obtained from "gene chips". These methods form the core of an important and rapidly growing field of research, known variously as biosequence analysis, bioinformatics or computational molecular biology. web site

Ecology Evolutionary and Environmental Biology (bulletin listing)

v	F	►	EEEB G4127	3	T 6:10-8	Disease Ecology and Conservation. A. Aguirre The course will describe the principles of disease investigation and disease ecology with emphasis on the effect of disease on human, animal, and ecosystem health, and the practice of conservation medicine.
v	F	►	EEEB G6110	3	T 10-12:50	Evolution I. R. DeSalle Prerequisites: Priority given to first-year students in EEB or Conservation Biology Certificate program. Lecture course covering principal topics of evolutionary biology from genetics, genome organization, population and quantitative genetics, the history of evolutionary theory, systematics, speciation and species concepts, co-evolution, and biogeography.

Electrical Engineering (bulletin listing)

v	F	►	BMEB W4011	3	T 6:50- 9:20	Computational Neuroscience I. A. Lazar
v	F	►	ECBM E4060	3	M 6:50-9:20	Introduction to Genomic Information Science and Technology. D. Anastassiou This course introduces the "information system paradigm" of molecular biology and genetics, in which biomolecular sequences are viewed as elements of digital information systems and recombination and other biomolecular processes are viewed as mathematical operations with simulation and visualization using simple computer programming in MATLAB. All concepts and methods will be introduced. No previous computer or biology background is required for the course. Electronic access for students who have time conflict with other courses.

Epidemiology (bulletin listing)

v	F	►	EPID P6400	3	R 5:30- 7:00	Principles of Epidemiology I. J. Encandela, D. Barrington Epidemiology is one of the pillars of public health. Epidemiologists study the distribution and determinants of disease in human populations; they also develop and test ways to prevent and control disease. The discipline covers the full range of disease occurrence, including genetic and environmental causes for both infectious and noninfectious diseases. Increasingly, epidemiologists view causation in the broadest sense, as extending from molecular factors at the one extreme, to social and cultural determinants at the other. This course introduces students to the theory, methods, and body of knowledge of epidemiology.
	Su	■	EPID P8401	3	TR 5-7:50	Evaluation of Drug Safety. J. Doyle, R. Gross This course is intended to provide students with an understanding of the methods and applications of pharmacoepidemiology (PE). Epidemiologic methods will be reviewed in the context of drug evaluation. Students will be exposed to the role of PE in the biopharmaceutical development process from the perspectives of regulators (i.e. FDA and EMEA), industry, and payers (e.g. managed care). The epidemiology core course is required as a prerequisite for this course.
	Sp	►	EPID P8404	3	M 1-2:50	Epidemiology and Genetics of Aging. J. H. Lee Prerequisite: Public Health P8438. Introduction to research in aging from both the epidemiologic and human genetics perspectives. Methodologic and substantive issues related to aging health profiles are discussed. Topics include study design, modeling of aging, active life expectancy, geriatric conditions, statistical genetics methods, gene mapping of aging phenotypes, human model system, and application to health policy. Required readings, three papers, and one problem set. preliminary syllabus
v	F	►	EPID P8414	3	W 10-11:50	Cancer Epidemiology. A. Neugut Prerequisites: Public Health P6400. Molecular and cellular biology of cancer and basic mechanisms of carcinogenesis. Role of chemical, viral, radiation, and genetic factors in human cancer. Sources of cancer patient data, with emphasis on acquisition and management of data for clinical and epidemiologic research. Natural history of cancer with analysis of time trends in cancer incidence, mortality, survival, and geographic distribution. Role of environmental factors (ecological/industrial/ occupational) in cancer causation. Fundamental issues in cancer screening and applications to public health and medical practice. Lectures and discussions. Assigned readings and term paper.
v	F	►	EPID P8475	3	R 2-4:50	Emerging Infectious Diseases. D. Despommier, S. Morse Prerequisites: Public Health P6400 and some familiarity with molecular biology; Public Health P8406 recommended. Examines the concept of emerging infectious diseases and our current understanding of emergence. Methods of identifying and studying emerging pathogens, factors responsible for disease emergence, and methods of surveillance and intervention are discussed. Examples of pathogens are considered. As problems closely related to the natural examples of emerging infectious diseases, public health aspects of biowarfare and bioterrorism are also discussed. By the end of the course, the student should understand what constitutes an emerging infection, appreciate why and how infections emerge, understand what approaches are currently available to track, predict, and respond to emerging infections, recognize the strengths and limitations of current capabilities for surveillance and control, and be able to identify similarities and differences between natural outbreaks of disease and biowarfare/bioterrorism. Lectures, presentations by invited speakers, and discussions. Midterm and final exam or paper.

Genetics and Development (bulletin listing)

v	Sp	►	GEND G4027	3	M 10-11:30 R 3-4:30	Principles of Developmental Biology. A. Tomlinson Required for first-year Genetics and Development students. Open to students from all departments, but students from outside the Genetics Department should consult the instructor before registering. The course emphasizes the molecular control of vertebrate embryogenesis. Divided into three main areas: early embryogenesis, developmental neurobiology, and the development and differentiation of specialized organs or lineages. A combination of faculty lectures and presentations by participating students.
v	F	►	GEND G4050	4	W 3-6	Advanced Eukaryotic Molecular Genetics. T. Bestor Required for second year Genetics and Development students. Prerequisite: at least one graduate-level biochemistry or molecular biology course, and the instructor’s permission. Advanced treatment of the principles and methods of the molecular biology of eukaryotes, emphasizing the organization, expression, and evolution of eukaryotic genes. Topics include reassociation and hybridization kinetics, gene numbers, genomic organization at the DNA level, mechanisms of recombination, transposable elements, DNA rearrangements, gene amplification, oncogenes, recombinant DNA techniques, transcription and RNA splicing. Students participate in discussions of problem sets on the current literature. web site
v	F	►	GEND G6210	3	T 1-4	Genetic Approaches to Biological Problems. R. Rothstein Required for first year Genetics and Development students. Open to all students. Designed to illustrate how genetic systems have played a fundamental role in our understanding of basic biological problems: mitosis and meiosis, chromosomal linkage and mapping, consequences of chromosomal rearrangements, mechanisms of recombination and gene conversion, the use of mutants to study gene structure, regulation and the cell cycle, uses of recombinant DNA in genetic analysis, and the genetic analysis of development in Drosophila.
	Sp	►	GEND G6211	3	T 1-4	Genetic Approaches to Biological Problems. F. D. Constantini Required for first-year Genetics and Development students. Continuation of Genetics G6210. Basic principles and current areas of interest in mouse and human genetics. An introduction to mouse genetics; X-chromosome inactivation and genomic imprinting; genetic manipulation of the mouse; genetics of mouse coat color; genetics of sex determination; the mouse T-complex; human linkage analysis; somatic cell genetics; physical mapping of the human genome; cytogenetics; Huntington’s disease; muscular dystrophy and Alzheimer’s disease; and gene therapy. web site

International and Public Affairs (bulletin listing)

	F	■	INAF U6014	3	M 6:10-9	Accounting. L. Errickson IPA Dept. approval required.
		■	PUAF U6607	3	M 2:10-4	Science/Tech & Economic Growth. R. Mazzoleni
	F	■	PUAF U8120	3	W 2:10-4	Writing for the Media. D. Johnston The goals of the course will be pursued through classroom discussions and a variety of street assignments tailored to expose you to community life, and to give you a keener "feel" for the media as a profession. Using the city as a laboratory, you will have opportunities to innovate news possibilities on your own for reporting and writing assignments, about international subjects as well as domestic. There will be writing every week.
v	Sp	■	PUAF U8203 -001	3	M 6:10-8	Project Management. T. Quaranta Project Management is an essential skill for all senior managers. Its successful implementation often determines whether an organization meets its objectives or not. Project management is defined as the application of knowledge, skills, tools and techniques to a broad range of activities in order to meet the requirements of the particular project. Project management knowledge and practices are best described in terms of their component processes: initiating, planning, executing, controlling and closing. Knowledge areas include scope management, time management, cost management, quality management, risk management, and change management.
	Sp	■	PUAF U8400	3	T 4:10-6	US Science and Technology Policy. B. Sampat An overview of the science and technology policy environment in the U.S., and an examination of key issues and sub-governmental systems. Policy will be reviewed in the context of a global economy and the competing system for innovation around the globe. This course will emphasize the policy in science arena more than the science in policy realm. Whether your interest is using scientific knowledge over the long term to influence broader policy discussions or to use the capabilities of the research community to solve socially important problems, it is essential to possess a thorough understanding of the norms of the research community and the mechanisms whereby research priorities are developed and funded. Note: Pre-registration not available for GSAS students. Register in January instead. web site

Microbiology (bulletin listing)

	Sp	►	MICR G4020	4	TR 2:30-3:30	Introduction to Immunology. H. Gu Survey of the major topics in basic immunology with an emphasis on the molecular basis for immune recognition and regulation.
v	Sp	►	MICR G4021	2	T 1-2	Current Topics in Immunology. TBAr
	F	►	MICR G4120	1	R 1 - 2:30	Intro to Computational Biology. O.S. Jovanovic
	Sp	►	MICR G4900	4	MW 2:30-4	Chromosome Dynamics and Genome Stability. L. Symington A seminar course to discuss recent advances in chromosome replication, segregation and DNA repair, processes essential for the stable inheritance of the genome. Guest lecturers will be invited to give seminars as part of the weekly Microbiology seminar series and will meet with the students to discuss their work. Papers to be discussed will focus on the use of several model systems and will emphasize the use of genetic approaches to understand these processes. There will be two 90 min classes/week for 12 weeks web site
v	F	►	MICR G6021	6	MWF 3-4:30	Virology. V. Racaniello A principle-based discussion of virology, emphasizing the common reactions that must be completed by all viruses for successful reproduction within a host cell and survival and spread within a host population. The molecular basis of alternative reproductive cycles, the interactions of viruses with host organisms, and how these lead to disease are presented with examples drawn from a set of representative animal viruses. The course will consist of lectures presented by members of the Department of Microbiology. Invited guest lecturers will discuss their research on specific problems in virology. web site

Neurobiology and Behavior (bulletin listing)

v	F	►	NBHV G4007	3	TR 4:30 - 6:30	Synaptic Transmission. B. McCabe, et al. A seminar on the cellular and molecular processes influencing synaptic transmission which will address the issue of how organelles and proteins localize to synapses by considering the transport and sorting of materials; the synthesis of proteins at synapses and mechanisms of retaining materials at synapses; the molecular mechanisms of exocytosis and endocytosis at the synapse; the physiology of synaptic transmission at excitatory and inhibitory synapses and how derangements of synaptic transmission give rise to neurological and psychiatric disorders. D.Goldberg, Bailey, MacDermott, and McCabe
	Sp	►	NBHV G4100	3	W 4-6	Biology of Neurological and Psychiatric Disorders. S. Rayport, R. Hen, W. Dauer Advanced seminar course on basicscience approaches to schizophrenia, Alzheimer's, Parkinson's, and Huntington's disease, anxiety disorders, epilepsy, etc. web site
	Sp	■	NBHV G6001	1		Responsible Conduct- Research/Policy. K. Miller
	Sp	►	NBHV G9002	3	MW 1:30-3:30	Introduction to Neural Development. C. Mason, B. McCabe, W. Grueber This course is open to graduate students in GSAS; previous coursework in Neuroscience required. Lecture and seminar presentations are restricted to students officially registered for the course.
	Sp	►	NBHV G9010	3		Neural Bases of Behavior. D. Kelley, I. Kupfermann An examination of how the nervous system controls behavior in a variety of animal model systems, both vertebrate and invertebrate (owls to crickets). Topics include: navigation, social communication, aggression, courtship, feeding, fear, and sleep. Lectures and student presentations.

Pathology (bulletin listing)

v	Sp	►	PATH G4500	3	MW 5-6:30	Cellular and Molecular Biology of Cancer. A. I. Neugut, E. Gelmann Required for students on the cancer training grant. Open to all students. An integrated and critical review of cancer biology, emphasizing recent research. Topics discussed include: natural history and epidemiology of cancer; morphology and behavior of cancer cells; DNA and RNA tumor viruses; oncogenes; tumor suppressor genes; signal transduction; the genetics of cancer; cancer and cellular differentiation; cancer causation: physical and chemical agents; multistage carcinogenesis; hormones, nutrients, and growth factors in cancer. Readings are largely original research papers and review articles. One 2-hour seminar per week. web site
v	F	►	PATH G6003	4.5	MWF 10-12	Molecular and Cellular Mechanism in Human Disease. R. Liem Preapproval required at the Biotech Program office. Open only to graduate students in the basic and medical science departments. Prerequisite: course director’s permission; knowledge of biochemistry and cell biology. The molecular and cellular basis for human disease, with an emphasis on modern research in characterization and treatment. Lectures, conferences, assigned readings, written and oral presentations.

Pharmacology (bulletin listing)

	Sp	►	PHAR G4600	3	W 4:10-6:30	Structure and Function of Membrane Channels. H. Colecraft, K. Allis, N. Harrison Prerequisite: Neural Science M6106 or the equivalent. This course and Physiology G4001 are recommended for students concentrating in Biophysics. A detailed analysis of the biophysical and structural properties of ionic channels in biological membranes.
v	F	►	PHAR G8001	3	MW 10-12	Principles of Systems Pharmacology. R. Robinson, K. Allis This course focuses on fundamental principles in systems pharmacology and their application. Topics include: the effect of body biochemical processes on the disposition of drugs, including quantitative expression of drug absorption, distribution, metabolism, and excretion (ADME); the use of statistical analysis in pharmacology; specific aspects of systems pharmacology, including autonomic and cardiovascular pharmacology, neuropharmacology and toxicology. These lectures deal with both basic principles and current topics within these disciplines.
v	Sp	►	PHAR G9600	4	TR 10-12	Molecular Pharmacology: from Membrane to Nucleus. S. Steinberg, K. Allis Required for all graduate students in pharmacology. Pre-requisite: familiarity with basic biochemistry and molecular biology. Introduction to molecular approaches to target identification and drug development and delivery for cellular and sub cellular processes that contribute to human disease. The principles of drug-receptor interactions; ion channels asmolecular targets of neurohormones and drugs; structure and function of G-protein coupled receptors; cytoplasmic signaling molecules including receptor and non-receptor tyrosine kinases and serine-threonine kinases; neuro-psychopharmacology;the pharmacology of inflammation; and novel approaches to gene-targeted pharmacology. Integration of molecular processes and human disease including cancer, neuro degenerative disease; cardiovascular disease, and psychiatric disorders is stressed.

Physiology and Cellular Biophysics (bulletin listing)

Sp	►	PSLG G4500	4	W 10-12	Advanced Topics in Immunology. C. Schindler
F	►	PSLG G6001	4	TR 4:30-6:30	Principles of Physiology. J. Loike, S. Lenhart
Sp	►	PSLG G6002	4	TR 4:30-6	Molecular Pathophysiology Cardiovascular System. A. Tall, J. Loike web site

Psychology

v	F	►	PSYC G4440	3	R 2:10-4	Topics in Neurobiology and Behavior. P. D. Balsam
v	Sp	►	PSYC G4440	3	M 6:10-8	Topics in Neurobiology and Behavior. C. Hart

Statistics (bulletin listing)

v	F	■	SIEO W4150	3	MW 2:40-3:55	Introduction to Probability and Statistics. G. Gallego Prerequisite: a working knowledge of calculus. Fundamentals of probability theory and statistical inference. Probabilistic models, random variable, useful distributions, expectations, laws of large numbers, central limit theorem. Statistical inference: point and confidence interval estimation, hypothesis tests, linear regression. web site
v	Sp	■	SIEO W4150	3	TR 7:40-8:55	Introduction to Probability and Statistics. I. Hueter Prerequisite: a working knowledge of calculus. Fundamentals of probability theory and statistical inference. Probabilistic models, random variable, useful distributions, expectations, laws of large numbers, central limit theorem. Statistical inference: point and confidence interval estimation, hypothesis tests, linear regression. web site