Research questions targeted in the lab concern concrete practical as well as more longer-term and open-ended topics. They include, but are not limited to, the following:

* How can information about white-matter and grey-matter integrity and resting-functional connectivity be combined to best predict future cognitive change in normal aging?

* How are structural differences related to functional activation, and do differences in structural health and functional activation explain age-related variability in cognition?

* How do changes in structural integrity, cerebral blood flow and resting-state connectivity impact the neural networks underlying a broad set of cognitive reference abilities (memory, fluid reasoning, perceptual speed, vocabulary ability)?

* What are the genetic substrates of imaging-based phenotypes derived from structural and functional brain networks?

* How do implicit and explicit regularization principles in multivariate decompositions guarantee biological meaning of the identified components?

* Does the dynamics of resting-state functional connectivity contain important information for cognitive aging? If so, does it provide more information than the dynamics of simple resting-state activity?