Ruben L. Gonzalez, Jr.
Department of Chemistry

work : +1 212-854-1096
rlg2118@columbia.edu


Gonzalez Group

Publications


2009

  • Bronson, J.E., Fei, J., Hofman, J.M. Gonzalez,R.L, Jr. and Wiggins, C.H. (2009). Learning rates and states from biophysical time series: A Bayesian approach to model selection and single-molecule FRET data. Biophys J, (in press).
  • Fei, J., Bronson, J.E., Hofman, J.M., Srinivas, R.L., Wiggins, C.H. and Gonzalez, R.L., Jr. (2009). Allosteric collaboration between elongation factor G and the ribosomal L1 stalk directs tRNA movements during translation. Proc Natl Acad Sci, USA, (in press, doi:10.1073/pnas. 0908077106) [PDF] [Supp Mat]
  • Effraim, P.R., Wang, J., Englander, M.T., Avins, J., Leyh, T.S.*, Gonzalez, R.L., Jr.* and Cornish, V.W.* (2009). Natural amino acids do not require their native tRNAs for efficient selection by the ribosome. Nat Chem Biol, (in press). (*Co-corresponding authors).
  • Sternberg, S., Fei, J., Prywes, N., McGrath, K. and Gonzalez, R.L., Jr. (2009). Translation factors direct intrinsic ribosome dynamics during translation termination and ribosome recycling. Nat Struct Mol Biol, 16, 861-868. [PDF] [Supp Mat]
    (Featured as a Research Highlight in Nat Chem Biol)

2008

  • Gonzalez, R.L., Jr. (2008). Navigating the RNA folding landscape. Nat Chem Biol, 4, 451-452. [PDF] 
  • Fei, J., Kosuri, P., MacDougall, D. and Gonzalez, R.L., Jr. (2008). Coupling of ribosomal L1 stalk and tRNA dynamics during translation elongation. Mol Cell, 30, 348-359. [PDF] [Supp Mat] 

2007

  • Wang, B., Fei, J., Nguyen,T., Gonzalez, R.L., Jr. and Lin, Q. (2007) Translocation of the ribosome in temperature-controlled microfluidic channels," Int. Conf. on Miniaturized Chemical and Biochemical Analysis Systems (MicroTAS '07), pp. 796-798, Paris, France. [PDF]
  • Wang, B., Fei, J., Nguyen, T., Gonzalez, R.L., Jr. and Lin, Q. (2007) Single-molecule detection in temperature-controlled microchannels," IEEE Int. Conf. Nano/Micro Engineered and Molecular Systems (NEMS '07), pp. 972-976, Bangkok, Thailand. [PDF]
  • Gonzalez, R.L., Jr., Chu, S. and Puglisi, J.D. (2007). Thiostrepton inhibition of tRNA delivery to the ribosome. RNA, 13, 348-359. [PDF]

2004

  • Dorywalska, M., Blanchard, S.C., Gonzalez, R.L., Jr., Chu, S. and Puglisi, J.D. (2004). Site-specific labeling of 16S rRNA for single-molecule spectroscopy. Nucleic Acids Res. 31, 182-189. [PDF]
  • Blanchard, S.C., Gonzalez, R.L., Jr., Kim, H.D., Chu, S. and Puglisi, J.D. (2004). tRNA selection and proofreading in translation. Nat Struct Mol Biol, 11, 1008-1014. [PDF] [Supp Mat]
  • Blanchard, S.C.*, Kim, H.D.*, Gonzalez, R.L., Jr.*, Puglisi, J.D. and Chu, S. (2004). tRNA dynamics on the ribosome during translation. Proc Natl Acad Sci USA, 101, 12893-12898. (*Equal Authorship). [PDF] [Supp Mat]

2003

  • Lynch, S.R., Gonzalez, R.L., Jr. and Puglisi, J.D. (2003). Comparison of X-Ray crystal structure of the 30S subunit-antibioticc omplex with NMR structure of decoding site oligonucleotide paromomycin complex. Structure, 11, 43-53. [PDF]

2000

  • Gonzalez, R.L., Jr. and Tinoco, I. Jr. (2000). NMR spectroscopic techniques for the identification and characterization of metal ion binding sites in RNA. Methods Enzymol, 338, 421-443. [PDF]
  • Yuen, H-W., Tinoco, I. Jr. and Gonzalez, R.L., Jr. (2000). The effect of magnesium (II) ion and cobalt (III) hexammine ion on an RNA pseudoknot. Berkeley Scientific, 4, 139-143.

1999

  • Gonzalez, L.R.,Jr and Tinoco, I. Jr. (1999). Solution Structure and Thermodynamics of a Divalent Metal Ion Binding Site in an RNA Pseudoknot. J Mol Biol, 289, 1267-1282. [PDF]