Sy Redding
Email: ser2153-at-columbia-dot-eduResearch Interests
Working as a joint student with Eric Greene, I am investigating the interactions between DNA and mismatch repair proteins. Through the use of novel single molecule techniques, I hope to discern both the unique processes by which these proteins locate their target sites, as well as how the various constituents of individual pathways “communicate” with one another. By understanding the nature of these interactions under the restrictions of our experiment, I can then formulate theoretical predictions of similar interactions in the cellular environment.
Education
- Ph.D. Candidate, Chemical Physics, Columbia University, 2014 (Advisors: David Reichman, Eric Greene)
- B.S. Physics w/Honors, Texas State University, 2009
Publications
- DNA interrogation by the CRISPR RNA-guided endonuclease Cas9. . Nature Online ahead of publication, (2014).
- DNA Dynamics and Single-Molecule Biology. . Chemical Reviews Article ASAP, (2014).
- How do proteins locate specific targets in DNA?. . Chemical Physics Letters 570, 1 (2013).
- The promoter-search mechanism of Escherichia coli RNA polymerase is dominated by three-dimensional diffusion. . Nature Structural and Molecular Biology 20, 174 (2013).
- Single-molecule imaging reveals target-search mechanisms during DNA mismatch repair. . Proceedings of the National Academy of Sciences 109, E3074 (2012).