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Reference Ability Neural Networks (RANN)

Four primary “reference abilities” are thought to underlie performance on a wide-range of cognitive tasks: episodic memory, fluid ability, perceptual speed, and vocabulary. This study uses fMRI to identify distinct networks of brain activity associated with each of the reference cognitive abilities. Healthy adults are recruited from each decade from 20 to 80.

PI: Yaakov Stern

 

Imaging of Cognition, Learning, and Memory in Aging

The goal of this study is to understand the neural basis of Cognitive Reserve (CR). CR is thought to mediate the relationship between age- or AD-related neuropathology and the functional or clinical consequences of this pathology. Various imaging and analytic approaches are used to model the relationship between age-related neural changes, CR, and cognition.

PI: Yaakov Stern

 

The Predictors Study

This is a multi-center, clinic-based study of predictors of progression of Alzheimer’s disease. Over 500 prevalent cases were followed longitudinally. The current Predictors cohort comprises incident AD cases identified through WHICAP.

PI: Yaakov Stern

 

Cognitive and Exercise Interventions for Cognition

This study examines the influence of aerobic training on specific aspects of cognitive function in young (25-40) and young-old (50-65) adults. The neural basis of cognitive improvement is explored via structural MRI, resting cerebral blood flow scans (arterial spin labeling) and cognitive activation fMRI studies

PI: Yaakov Stern