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and when he came to the part that described the drug calming patients, he thought, “We could stand some calming around here, and I'll give it to these people or to a group of them.” He got some of the drug and he did, indeed, give it to them, but he gave it in such small doses that nothing happened. By chance, someone gave larger doses to another group and they seemed to be calmed. And from then on, they tried it on more people and they found that, indeed, it did have a calming effect. Klein made another important contribution that he hasn't been sufficiently recognized for--it's very important--he discovered that Iproniazid, which was a drug that was used for TB at the same time isoniazid was tested and which was said at the time to elevate the mood of the patients and to make them very gay and lively, that it would bring severely depressed people out of their depressions. And these acute psychotic patients that were depressed and would stay in catatonic states would be brought out and were enabled to lead socially possible lives.

The discovery of the usefulness of Iproniazid gave drug houses an idea of what they could, and they made other drugs less toxic than Iproniazid; it was called Marsalid, when it was used as an anti-depressant. It's now off the market, because it had some side effects which caused jaundice. But there are a number of relatives of it and other drugs which psychic energizers or anti-depressants, and people who are in depressions don't really need to be in acute depressions anymore, because there are anti-depressants which are not toxic and which are extremely