Research Areas, Findings and Publications

 
                           
   


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1.    Natural history of alcohol use disorders.

This work was begun in the 1980's using previously collected national data. In 1991 - 1992, a new sample of 962 community residents were interviewed who had been screened for drinking patterns that increased their risk of alcohol use disorders. One year later, subjects were re-interviewed. A ten-year follow-up is currently underway.

     Findings from this research include:

Topics of current investigation in this area include predictors of the onset of alcohol dependence (including transition from alcohol abuse) and long-term course of heavy drinking and alcohol use disorders among subjects not in treatment. This research is supported by the National Institute on Alcohol Abuse and Alcoholism ( NIAAA ).

     Selected Publications:

  Hasin D, Grant BF, Endicott J: The natural history of alcohol abuse; implications for definitions of alcohol use disorders. American Journal of Psychiatry 147:1537-1541, 1990.

Hasin D, Van Rossem R, McCloud S, Endicott J: Differentiating DSM-IV alcohol dependence and abuse by course: community heavy drinkers. Journal of Substance Abuse 9:127-135, 1997.

Hasin D, Paykin A, Meydan K, Grant B: Withdrawal and tolerance: their prognostic significance in DSM-IV alcohol dependence. Journal of Studies on Alcohol 63:431-438, 2000.

Hasin D, Paykin A, Endicott J: Course of DSM-IV alcohol dependence in a community sample: effects of parental history and binge drinking. Alcoholism: Clinical and Experimental Research 25: 411-414, 2001.

         Additional selected publications:  1





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2.    Measurement issues in substance use and psychiatric disorders.

       A wide variety of studies have been conducted on reliability and validity of substance use and psychiatric disorders. These studies have been conducted in clinical, community and national samples, in the U.S. and abroad. The work has been funded by the National Institute on Drug Abuse ( NIDA ) and the National Institute on Alcohol Abuse and Alcoholism ( NIAAA ).

       Findings from this research include:

Topics of current investigation in this area include a test-retest study of an updated version of the PRISM, and computerization of diagnostic interviews to improve ease of administration, reduce administration time, and improve reliability. This research is currently supported by the National Institute on Drug Abuse ( NIDA ) and the National Institute on Alcohol Abuse and Alcoholism ( NIAAA ). Also under investigation is a test-retest reliability of the World Health Organization (WHO) Disability Assessment Schedule (WHO-DAS), part of a World Health Organization study.

     Selected Publications:

  Hasin D, Trautman K, Miele G, Samet S, Smith M, Endicott J: Psychiatric Research Interview for Substance and Mental Disorders (PRISM): Reliability for substance abusers. American Journal of Psychiatry 153:1195-1201, 1996.

Hasin D, Carpenter K, McCloud S, Smith M, Grant B: The Alcohol Use Disorder and Associated Disabilities Interview Schedule (AUDADIS): reliability of alcohol and drug modules in a clinical sample. Drug and Alcohol Dependence 44:133-141, 1997.

Hasin D, Grant B, Cottler L, Blaine J, Towle L, Ustun T, Sartorius N: Nosological comparisons of alcohol and drug diagnoses: a multisite, multi-instrument international study. Drug and Alcohol Dependence 47: 217-226, 1997.

Hasin D, Van Rossem R, McCloud S, Endicott J: Alcohol dependence and abuse diagnoses: validity in community sample heavy drinkers. Alcoholism: Clinical and Experimental Research 21:213-219, 1997.

Hasin D, Paykin A: Alcohol dependence and abuse diagnoses: concurrent validity in a nationally representative sample. Alcoholism: Clinical and Experimental Research 23:144-150, 1999.

Miele GM, Carpenter KM, Cockerham MS, Trautman KD, Blaine J, Hasin DS: Substance Dependence Severity Scale (SDSS): Reliability and validity of a clinician-administered interview for DSM-IV substance use disorders. Drug and Alcohol Dependence 59:63-75, 2000.

         Additional selected publications:  2





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3.    Comorbidity of psychiatric and substance use disorders in treatment settings.

       Research in this area has been conducted in several clinical and general population samples, and has largely focussed on the relationship of major depression and alcohol and drug use disorders to each other.

       Findings from this research include:

Topics of current investigation in this area include predictors of the outcome of major depression in these patients, and identification of factors that potentiate the effects of depression during abstinence on relapse of substance dependence and suicide attempts. This research is supported by the National Institute on Drug Abuse NIDA and NIAAA.

     Selected Publications:

  Hasin D, Endicott J, Lewis C: Alcohol and drug abuse in patients with affective syndromes. Comprehensive Psychiatry 26:283-295, 1985.

Hasin D, Endicott J, Keller MB: RDC alcoholism in patients with major affective syndromes: 2-year course. American Journal of Psychiatry 146:318-323, 1989.

Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: The effects of major depression on alcoholism: five-year course. American Journal on Addictions 5:144-155, 1996.

Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: Five-year course of major depression: Effects of comorbid alcoholism. Journal of Affective Disorders 41:63-70, 1996.

Hasin D, Liu X-H, Nunes E, Samet S, McCloud S, Endicott J: Effects of independent and substance-induced major depression on remission and relapse in DSM-IV substance dependence. In press, Archives of General Psychiatry.

         Additional selected publications:  3





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4.    Issues in Psychiatric Epidemiology.

       Working collaboratively with other investigators, a variety of issues have been addressed in psychiatric epidemiology. These have been investigated in national or community data sets.

       Findings from this research include:

     Selected Publications:

  Hasin D, Link B: Age and recognition of depression: implications for a cohort effect in major depression. Psychological Medicine 18:683-688, 1988.

Hasin D, Grant BF, Harford TC, Hilton M, Endicott J: Multiple alcohol-related problems in the United States: on the rise? Journal of Studies on Alcohol 51:485-493, 1990.

Hasin D, Grant BF, Dufour M, Endicott J: Alcohol problems increase while physician attention declines: 1967-1984. Archives of Internal Medicine 150:397-400, 1990.

Hasin D: Treatment/self-help for alcohol-related problems: relationship to social pressure and alcohol dependence. Journal of Studies on Alcohol 55:660-666, 1994.

Hasin D, Paykin A: Dependence symptoms but no diagnosis: diagnostic "orphans" in a 1992 national sample. Drug and Alcohol Dependence 53: 215-222, 1999.

Hasin D, Grant B: Major depression in 9,264 former drinkers: association with past alcohol dependence. Under review.

         Additional selected publications:  4





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5.    Epidemiology and genetics of alcohol consumption and dependence symptoms in Israel.

Alcohol consumption in Israel has been shown to be very low in numerous studies conducted since the 1970's. However, evidence now suggests that Israel may now be undergoing a period of change in terms of alcohol consumption, with younger adults and recent Russian immigrants drinking more. Elevated prevalence of ADH2*2, an allele of a gene involved in the metabolism of alcohol in the liver, is elevated among Jewish groups in general, including Jewish Israelis. Thus, Israel presents a unique conjunction of environmental and genetic influences on alcohol consumption and dependence symptoms. Data have been investigated from an Israeli national survey and a pilot community survey conducted by Dr. Hasin's group.

       Findings from this research include:

Topics of current investigation in this area include the interaction of gene and environmental effects in the occurrence of heavy drinking and alcohol dependence symptoms, and social influences on increased drinking among younger Israeli adults. This research is supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA).

     Selected Publications:

  Hasin D, Rahav G, Meydan J, Neumark Y: The drinking of earlier and more recent Russian immigrants to Israel: comparison to other Israelis. Journal of Substance Abuse 10:341-353, 1998.

Rahav G, Hasin D, Paykin A: Drinking patterns of recent Russian immigrants and other Israelis: 1995 national survey results. American Journal of Public Health 89:1212-1216, 1999.

Aharonovich E, Hasin D, Rahav G, Meydan J, Neumark Y: Differences in drinking patterns among Ashkenazic and Sephardic Israeli adults. Journal of Studies on Alcohol 62:301-305, 2001.

Neumark Y, Rahav G, Teichman M, Hasin D: Alcohol drinking patterns among Jewish and Arab men and women in Israel. In press, Journal of Studies on Alcohol.

Hasin D, Aharonovich E, Liu X, Maman Z, Matseone K, Carr L, Li T: Alcohol and ADH2 in Israel: Ashkenazis, Sephardics and Recent Russian Immigrants. Submitted.




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6.    Other areas of research

Dr. Hasin has conducted research collaboratively with investigators in a number of other research areas.
Selected Publications on this work include the following:

  Hasin D, Grant BF: Neuropsychological functioning in alcoholics: psychiatric comorbidity, drinking history, and demographic characteristics. Comprehensive Psychiatry 28:520-529, 1987.

Hasin D, Grant BF, Weinflash J: Male/female differences in alcohol-related problems: alcohol rehabilitation patients. International Journal of Addictions 23:437-448, 1988.

Martin J. Hasin D: Drinking, alcoholism and sexual behavior in a cohort of gay men. Drugs and Society 5: 49-68,1991.

Spitzer R, Devlin M, Walsh BT, Hasin D, Wing R, Marcus M, Stunkard A, Wadden T, Yanovski S, Agras S, Mitchell J, Nonas C: Binge eating disorder: a multisite field trial of the diagnostic criteria. International Journal of Eating Disorders 11:191-203, 1992.

Carpenter KM, Miele GM, Hasin DS: Does motivation to change mediate the effect of DSM-IV substance use disorders on treatment utilization and substance use? In press, Addictive Behaviors.


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