Xiao Fan

Associate Research Scientist, Summer 2018 - fall 2022
Current Position: Assistant Professor at University of Florida
Ocean University of China
University of Alberta
Google Scholar

(Bio as of summer 2019) I joined Columbia University in 2018 as a postdoc co-mentored by Dr. Wendy Chung and Dr. Yufeng Shen. I study rare genetic causes of human diseases using next-generation sequencing data. Additionally, I am interested in improving genetic variant functional interpretation using machine learning. Before joining the lab, I was a postdoc at Mayo Clinic working on genotype-phenotype association and phenotyping from electronic health records. I received my PhD in computational biology from the University of Alberta. During that time, I was working on predicting microRNA targets and intrinsically disordered protein regions using machine learning.

  1. SHINE: Protein Language Model based Pathogenicity Prediction for Inframe Insertion and Deletion Variants Briefings in Bioinformatics. 2023
  2. Predicting functional effect of missense variants using graph attention neural networks Nature Machine Intelligence. 2022
  3. The genetic architecture of pediatric cardiomyopathy AJHG. 2022
  4. Penetrance of breast cancer genes from the eMERGE III Network JNCI Cancer Spectrum. 2021
  5. Genotype and defects in microtubule-based motility correlate with clinical severity in KIF1A-associated neurological disorder HGG Advances. 2021
  6. Functional interrogation of DNA damage response variants with base editing screens Cell. 2021