Project 5

Sensory processing deficits in the schizophrenia prodrome

Project 5 aims to:

• Introduce a sensory processing battery (behavioral measures/ERP procedures) to the existing RAP baseline procedures and assess the extent to which sensory deficits are present in the prodromal stage of illness
• Evaluate short-term changes in sensory processing and ERPs at six months in subjects who are medication free compared to those stabilized on medication
Assess long-term change in processing associated with a tw-year retest

This project represents an innovative integration of two theoretical approaches that have great potential for improving prediction of schizophrenia and for helping to clarify the neural mechanisms involved in the onset of psychosis. Although late adolescence/early adulthood is the period when onset typically occurs, few prospective prodromal studies have focused on the changes in brain function that occur during this period. Information about the neural processes leading to illness during this early phase of development could both improve accurate prediction and potentially lead to novel interventions targeting the specific abnormalities identified. The project incorporates event-related potential (ERP) and behavioral measures of sensory processing dysfunction to enhance existing neurocognitive batteries.

Investigators: Barbara Cornblatt, PhD (Principal Investigator), Ricardo Carrion, PhD (Co-Principal Investigator)