Effective public health practice leading to healthy mothers and infants depends in part upon basic knowledge about pregnancy, prenatal care, safe labor and delivery, and breastfeeding.
Signs and symptoms which may alert women, and their health care providers, to the possibility of pregnancy include: a missed menstrual period, nausea and/or vomiting, increased frequency of urination, fatigue, breast tenderness, and/or mood changes.
Often, medical providers confirm suspected pregnancy, usually by conducting a pregnancy-related history, performing a urine pregnancy test, and/or conducting a physical examination. In addition, many women use highly sensitive over-the-counter pregnancy tests.
Stages of Pregnancy
A full-term pregnancy is considered to last 40 weeks from the first day of the pregnant woman's last menstrual period (LMP) prior to fertilization. Pregnancy is generally divided into trimesters:
Fertilization, the fusion of the male sperm with the female ova in the fallopian tube to form a single cell called the zygote. Once formed, the rapidly dividing zygote travels towards the uterus (which takes about three days). Transport is facilitated by ciliated epithelium (epithelium are hair-like structures that wave actively in one direction) and subtle contractions of the fallopian tube.
When the zygote reaches the uterus it has become a blastocyst (a small cluster of cells) that remains in the uterus for four or five days before it penetrates into the thickened endometrium (uterine lining). This process, called implantation occurs approximately 10 days after fertilization and marks the beginning of the embryonic period (development which occurs during the first eight weeks of pregnancy).
The Implanted Blastocyst (Maria Wawer Slide)
For the first eight weeks post-fertilization, and ten weeks from the last menstrual period (LMP), the cells are termed an “embryo.” After eight weeks post-fertilization and ten weeks from LMP until birth, the term changes to “fetus.” During the first trimester, the embryo is the most susceptible to environmental influences; during this stage, the majority of organ system formation occurs.
THE DEVELOPING PLACENTA
During the early stages of embryonic development, a thin membrane called the amnion develops, which surrounds and protects the embryo. The membrane contains amniotic fluid, which cushions the fetus and helps to maintain even temperature throughout pregnancy.
The outer cells of the embryo form projections, called “villi” that attach themselves to the uterine wall. This attachment becomes the placenta, a vascular spongy structure through which the embryo, and later the developing fetus, derives oxygen, antibodies and nutrients from the maternal blood supply. Waste products also pass from the fetus back to the maternal blood supply through the placenta. The embryo is connected to the placenta by the umbilical cord.
Soon after implantation, the placenta secretes a hormone called HCG (human chorionic gonadotrophin). HCG prevents the disintegration of the corpus luteum, which will secrete large quantities of estrogen and progesterone. Increased estrogen production also causes the enlargement of the uterus, breasts, and external genitalia. Increased progesterone helps to maintain the endometrium, prevents uterine contractions during the pregnancy, and prepares the breasts for lactation.
By the end of the fourth week, all major organ systems begin to form. Primitive nervous system development begins with the neural tube (the beginnings of the brain and the spinal cord). The cardiovascular system also begins to develop. The heart begins beating during the 4th week, and limb buds (which eventually become the arms and legs) also develop by the fourth week. By the end of eight weeks, all major body systems (circulatory, nervous, digestive and urinary systems) continue to develop and function.
The end of the first trimester marks the beginning of the fetal period (from 9-12 weeks), and is characterized by continued structural growth and development of the major organ systems and the external genital organs.
The second trimester occurs during weeks 13-27 and is marked by accelerated growth, the development of reflex responses and muscular activity. The placenta is fully developed and the brain undergoes the most important period of growth.
The third trimester begins at week 28 and continues until the birth of the baby. All major organ systems continue to grow and mature including the brain, the kidneys and the lungs. By approximately the 36th week, the fetal head may “drop” into the pelvis, a process called lightening. The fetus is considered full-term at >= 37 weeks. It weighs approximately 3000-3600 grams, unless small for gestational age (SGA).
For more information about pre-term infants, visit
The health status of a woman prior to and during pregnancy is critically important for the health and well being of the woman, and for the outcome her pregnancy. However, in the United States and around the world, standards vary.
Comprehensive prenatal care (also know as antenatal care) is designed to:
Labor and Delivery
Labor and delivery is the process that transports the fetus from the uterus through the vagina (birth canal) and results in the birth of a baby. Signs and symptoms of impending labor are: lightening (the descent of the fetal head into the pelvis), softening of the cervix, Braxton Hicks contractions (contractions which occur that have no measurable effect on the cervix), bloody show (the expulsion of a mucus plug from the cervix), a spurt of energy, and increased gastrointestinal discomfort. The presence of contractions, which become regular and increase in frequency, intensity and duration is an important sign that labor has begun.
Labor is divided into four stages, briefly described below:
Regular contractions of the uterus cause the cervix to become thinner and the cervical os to open wider (dilation). Rupture of membranes (the amniotic sac containing the amniotic fluid breaks producing a gush of fluid) usually takes place during this phase. The first stage of labor continues from the onset of labor, until the dilation of the cervical os progresses to 10 cm.
In the second stage, the cervical opening has completely dilated (to 10 cm.) Contractions last longer and are more frequent. The woman is instructed to “push” while she experiences contractions, which facilitates the passage of the fetus through the cervix, and into the vaginal canal. The fetal head descends as the woman pushes the baby with each contraction. When birth is imminent, the head of the fetus can be seen (crowning). The second stage ends with the delivery of the baby.
The delivery of the placenta, membranes of the amniotic sac, and the umbilical cord (sometimes referred to as the afterbirth) occur during the third stage. The uterus continues to contract, which results in the separation of the placenta from the uterine wall. Placental delivery normally takes place within five minutes of infant delivery.
Marking the beginning of the post-partum period, the fourth stage takes place between one and four hours immediately following the delivery of the placenta. During this time, contractions of the uterus close off the blood vessels leading to the site of placental attachment.
There are many factors which contribute to decisions about obstetrical management during childbirth which include: maternal preference and health status, fetal maturity and health status, fetal position, the stage of labor, and maternal and fetal responses to the labor.
Interventions that monitor both fetal and maternal responses to labor include internal and external fetal heart rate monitoring, maternal blood pressure, and fetal scalp sampling.
Decisions about the use of pain medication and Pitocin (a synthetic hormone which enhances uterine contractions) are also made based on the clinical situation.
In the United States, many women take childbirth education classes in order to learn relaxation and breathing techniques learned during childbirth education classes. These techniques help to reduce anxiety and provide varying levels of pain relief.
At the time of delivery, the prenatal care provider may perform an episotomy, a surgical incision of the perineum (the area between the vagina and the anus) in order to prevent the tissues from tearing, and/or to expedite delivery. The incision is repaired following delivery.
A Cesarean Section (C-Section) is a surgical procedure that allows for the birth of a baby through the abdomen instead of the vagina. C-Sections are performed in instances where vaginal delivery presents an unreasonable risk to the mother and/or the fetus (i.e. placental abnormalities, fetal position, disproportion between the size of the fetus' head and the size the woman's pelvis, and other medical problems including known HIV infection under certain circumstances). Complications related to C-Section are higher than those related to vaginal delivery, as with any surgery. C-Sections should be reserved for circumstances where the benefits outweigh the risks.
The post-partum period, also know as the puerperium, begins with the delivery of the placenta and last for six weeks following delivery. During this period, the uterus goes through a process called involution (reduction in the size of the uterus following childbirth). The uterus discharges a fluid called lochia (fluid containing blood and other fluids) for a period of two-to-three weeks. During the first two-to-three days, the lochia is red because it is filled with blood. As post-partum adjustment continues, the lochia becomes lighter in color.
Lactation, the normal physiologic response of all women following childbirth, causes the mammary glands (breasts) to secrete milk. Lactation involves both milk production and milk “let-down.” During pregnancy, the placenta secretes high levels of estrogen and progesterone to prepare the breasts for lactation. Following the delivery of the placenta, the sudden drop in estrogen and progesterone triggers the pituitary gland to produce the hormone prolactin that stimulates the production of milk. Infant suckling stimulates the posterior pituitary gland to produce the hormone oxytocin which allows milk to “let down” (a reflex resulting in the release of milk from the alveoli to the milk ducts of the breasts). Without continued infant suckling, milk production and let down will cease within one-2 weeks.
Benefits of Breast-feeding
Breast milk is an ideal source of nutrition for infants because it provides the baby with essential nutrients, increases immunity, may prevent the development of allergies, and helps to foster an emotional bond between the mother and newborn. Breast milk is readily available, inexpensive, and safe in most situations.
HIV infection can be transmitted from an HIV-positive woman to her baby through breast-feeding. Wherever possible, women are advised to learn their HIV status during pregnancy, so that they can make informed decisions about their pregnancy, their own health, and choices for infant feeding.
Women who are HIV-positive are advised not to breastfeed. However, in locations where the availability of clean water is limited, and/or the cost of infant formula is beyond the means of the family, HIV-positive new mothers face a difficult choice.