David Brenner works in the
Center for Radiological Research
Is that Imaging Test Really Necessary?
- Biophysical modeling
- Radiation biology
- Low dose risk estimation
- Radiotherapy
- Radon
Contact Information
David J. Brenner
Center for Radiological Research
Columbia University
630 W. 168th St.
New York, NY 10032Tel: (212) 305-5660
Fax: (212) 305-3229
email: djb3@columbia.edu
Undergraduate:
B.A., Physics Philosophy, Oxford
University, Oxford, U.K., 1974
M.A., Physics Philosophy, Oxford University, Oxford, U.K., 1979
Ph.D. Physics, University of Surrey, Guildford, U.K., 1980
D. Sc. Honorary Degree, Oxford University, 1996
Current academic and Professional appointments
Higgins Professor of Radiation Biophysics, College of Physicians & Surgeons of Columbia University
Director of the Center for Radiological Research (CRR)
Director of the Columbia University Radiological Research Accelerator Facility (RARAF)
Member of the National Council on Radiation Protection and Measurements (NCRP)
Current Research
David Brenner focuses on developing mechanistic models for the effects of ionizing radiation on living systems, both at the chromosomal and the animal (or human) levels. He divides his research time roughly equally between the effects of high doses of ionizing radiation (relating to radiation therapy) and the effects of low doses of radiation (relating to medical, environmental and occupational exposures).
At the chromosomal level, he has focused on the mechanisms of radiation-induced chromosome aberrations, and the potential of chromosome aberrations for use as biomarkers for past exposure to different types of radiations.
In the field of medical imaging, he has focused on the risk / benefit balance of the higher-dose imaging techniques, particularly computed tomography (CT).
In the field of radiotherapy, he has focused on optimizing fractionation schemes for different tumor types, to maximize tumor killing and minimize serious side effects; this includes modeling the mechanisms of radiotherapy-induced second cancers, with the goal of reducing second cancer risks.
Environmentally, he has focused on the biological effects of radon, both at the chromosomal and the human levels.
Brenner is the author of two books on radiation for the lay person: Making the Radiation Therapy Decision and Radon, Risk and Remedy. Additionally, he has published more than 200 papers in the peer-reviewed scientific literature. He was the recipient of the 1991 Radiation Research Society Annual Research Award, and the 1992 National Council on Radiation Protection and Measurements Award for Radiation Protection in Medicine.
As well as being Director of the Center for Radiological Research, Brenner is the Director of the Radiological Research Accelerator Facility and Principal Investigator of the Center for High-Throughput Minimally-Invasive Radiation Biodosimetry.
Single copies of the articles can be downloaded and printed for the reader's personal research and studied for informational purposes only.
Kirkpatrick J.P., Brenner D.J. and Orton C.G. Point/Counterpoint. The linear-quadratic model is inappropriate to model high dose per fraction effects in radiosurgery. Med. Phys. 36:3381-3384 (2009). [abstract] [PDF]
Brenner D.J., Elliston C.D., Hall E.J. and Paganetti H. Reduction of the secondary neutron dose in passively scattered proton radiotherapy, using an optimized pre-collimator/collimator. Phys. Med. Biol. 54:6065-6078 (2009). [abstract] [PDF]
Shuryak I. and Brenner D.J. A model of interactions between radiation-induced oxidative stress, protein and DNA damage in Deinococcus radiodurans. J. Theor. Biol. Epub ahead of print (2009). [abstract] [PDF]
Shuryak I., Hahnfeldt P., Hlatky L., Sachs R.K. and Brenner D.J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part I: Approach. Radiat. Environ. Biophys. 48:263-274 (2009). [abstract] [PDF]
Shuryak I., Hahnfeldt P., Hlatky L., Sachs R.K. and Brenner D.J. A new view of radiation-induced cancer: integrating short- and long-term processes. Part II: second cancer risk estimation. Radiat. Environ. Biophys. Epub ahead of print (2009). [abstract] [PDF]
Bigelow A.W., Garty G., Funayama T., Randers-Pehrson G., Brenner D.J. and Geard C. Expanding the question-answering potential of single-cell microbeams at RARAF, USA. J. Radiat. Res. 50: Suppl. A:A21-A28, 2009. [abstract] [PDF]
Hei T.K., Ballas L.K., Brenner D.J., Geard C.R. Advances in radiobiological studies using a microbeam. J. Radiat. Res. 50 Suppl. A:A7-A12 (2009). [abstract] [PDF]
Bertucci A., Pocock R.D., Randers-Pehrson G., Brenner D.J. Microbeam irradiation of the C. elegans nematode. J. Radiat. Res. 50 Suppl. A:A49-A54 (2009). [abstract] [PDF]
Bigelow A.W., Geard C.R., Randers-Pehrson G., and Brenner D.J. Microbeam-integrated multiphoton imaging system. Rev. Sci. Instrum.79:123707 (2008). [abstract] [PDF]
Brenner DJ. Should computed tomography be the modality of choice for imaging Crohn's disease in children? The radiation risk perspective. Gut 57:1489-1490 (2008). [abstract] [PDF]
Ahuja A.K., Barber R.C., Hardwick R.J., Weil M.M., Genik P.C., Brenner D.J. and Dubrova Y.E. The effects of Atm haploinsufficiency on mutation rate in the mouse germ line and somatic tissue. Mutagenesis 23:367-370 (2008). [abstract] [PDF]
Brenner DJ. The linear-quadratic model is an appropriate methodology for determining isoeffective doses at large doses per fraction. Semin. Radiat. Oncol. 18:234-239 (2008). [abstract] [PDF]
Bigelow A.W., Brenner D.J., Garty G. and Randers-Pehrson G. Single-particle/single-cell ion microbeams as probes of biological mechanisms. IEEE Trans. Plasma Sci. 36:1424-1431 (2008). [abstract] [PDF]
Hei T.K., Zhou H., Ivanov V.N., Hong M., Lieberman H.B., Brenner D.J., Amundson S.A., and Geard C.R. Mechanism of radiation-induced bystander effects: a unifying model. J. Pharm. Pharmacol. 60:943-950 (2008). [abstract] [PDF]
Brenner D.J. Effective dose: a flawed concept that could and should be replaced. Br. J. Radiol. 81:521-523 (2008). [abstract] [PDF]
Brenner D.J. and Huda W. Effective dose: A useful concept in diagnostic radiology? Radiat. Prot. Dosimetry 128:503-508 (2008). [abstract] [PDF]
Hall E.J. and Brenner D. J. Cancer risks from diagnostic radiology. Br. J. Radiol. 81:362-378 (2008). [abstract] [PDF]
Brenner D.J. and Hall E.J. Secondary neutrons in clinical proton radiotherapy: A charged issue. Radiother. Oncol. 86:165-170 (2008). [abstract] [PDF]
Shuryak I., Sachs R.K. and Brenner D.J. Biophysical models of radiation bystander effects: 1. Spatial effects in three-dimensional tissues. Radiat. Res. 168:741-749 (2007) [abstract] [PDF]
Brenner D.J. and Hall E.J. Computed Tomography - An increasing source of radiation exposure. N. Engl. J. Med. 357:2277-2284 [PDF]
Sachs R.K., Shuryak I., Brenner D.J., Fakir H., Hlatky L. and Hahnfeldt P. Second cancers after fractionated radiotherapy: Stochastic population dynamics effects. J. Theoretical Biol. 249:518-531 (2007). [abstract] [PDF]
Hodgson D.C., Koh E-S., Tran T.H., Heydarian M., Tsang R., Pintilie M., Xu T., Huang L., Sachs R.K. and Brenner D.J. Individualized estimates of second cancer risks after contemporary radiation therapy for Hodgkin lymphoma. Cancer 110:2576-2586 (2007). [abstract] [PDF]
Kleinman N.J., David J., Elliston C.D., Hopkins K.M., Smilenov L.B., Brenner D.J., Worgul B.V., Hall E.J. and Lieberman H.B. Mrad9 and atm haploinsufficiency enhance spontaneous and x-ray-induced cataractogenesis in mice. Radiat. Res. 168:567-573 (2007). [abstract] [PDF]
Brenner D.J., Shuryak I., Russo S. and Sachs R.K. Reducing second breast cancers: a potential role for prophylactic mammary irradiation. J. Clin. Oncol. 25:4868-4872 (2007). [abstract] [PDF]
Nikolaev A., Oks E.M., Savkin K., Yushkov G.Yu., Brenner D.J., Johnson G., Randers-Pehrson G., Brown I.G. and MacGill R.A. Surface resistivity tailoring of ceramic insulators for an ion microprobe application. Surface & Coatings Technology 201:8120-8122 (2007). [PDF]
Sedelnikova O.A., Nakamura A., Kovalchuk O., Koturbash I., Mitchell S.A., Marino S.A., Brenner D.J. and Bonner W.M. DNA double-strand breaks form in bystander cells after microbeam irradiation of three-dimensional human tissue models. Cancer Res. 67:4295-4302 (2007). [abstract] [PDF]
Koh E.S., Tran T.H., Heydarian M., Sachs R.K., Tsang R.W., Brenner D.J., Pintilie M., Xu T., Chung J., Paul N. and Hodgson D.C. A comparison of mantle versus involved-field radiotherapy for Hodgkin's lymphoma: reduction in normal tissue dose and second cancer risk. Radiat. Oncol. 2:13 (2007). [abstract] [PDF]
Brenner D.J. Induced second cancers after prostate-cancer radiotherapy: No cause for concern? Int. J. Radiat. Oncol. Biol. Phys. 65:637-639 (2006). [abstract] [PDF]
Brenner D.J. It is time to retire the computed tomography dose index (CTDI) for CT quality assurance and dose optimization. Med. Phys. 33:1189-1190 (2006). [abstract] [PDF]
Brenner D.J. and Sachs R.K. Estimating radiation-induced cancer risks at very low doses: rationale for using a linear no-threshold approach. Radiat. Environ. Biophys. 44:253-256 (2006). [abstract] [PDF]
Garty G., Ross G.J., Bigelow A.W., Randers-Pehrson G. and Brenner D.J. Testing the stand-alone microbeam at Columbia University. Radiat. Prot. Dosimetry 122:292-296 (2006). [abstract] [PDF]
Hall E.J., Worgul B.V., Smilenov L., Elliston C.D. and Brenner D.J. The relative biological effectiveness of densely ionizing heavy-ion radiation for inducing ocular cataracts in wild type versus mice heterzygous for the ATM gene. Radiat. Environ. Biophys. 45:99-104 (2006). [abstract] [PDF]
Shuryak I., Sachs R.K., Hlatky L., Little M.P., Hahnfeldt P. and Brenner D.J. Radiation-induced leukemia at doses relevant to radiation therapy: Modeling mechanisms and estimating risks. JNCI 98:1974-1806 (2006). [abstract] [PDF]
Ross G.J., Bigelow A.W., Randers-Pehrson G., Peng C.C. and Brenner D.J. Phase-based cell imaging techniques for microbeam irradiations. Nucl. Instrum. Methods Phys. Res. B 241:387-391 (2005). [PDF]
Garty G., Ross G.J., Bigelow A., Randers-Pehrson G. and Brenner D.J. A microbeam irradiator without an accelerator. Nucl. Instrum. Methods Phys. Res. B 241:392-396 (2005). [PDF]
Bigelow A.W., Randers-Pehrson G., Kelly R.P. and Brenner D.J. Laser ion source for Columbia University's microbeam. Nucl. Instrum. Methods Phys. Res. B 241: 874-879 (2005). [PDF]
Garty G., Randers-Pehrson G. and Brenner D.J. Development of a secondary-electron ion-microscope for microbeam diagnostics. Nucl. Instrum. Methods Phys. Res. B 231:60-64 (2005) [PDF]
Bigelow A.W., Ross G.J., Randers-Pehrson G. and Brenner D.J. The Columbia University Microbeam II endstation for cell imaging and irradiation. Nucl. Instrum. Methods Phys. Res. B 231:202-206 (2005) [PDF]
Ross G.J., Garty G., Randers-Pehrson G. and Brenner D.J. A single-particle/single-cell microbeam based on an isotopic alpha source. Nucl. Instrum. Methods Phys. Res. B 231:207-211 (2005) [PDF]
Zhou H., Ivanov V.N., Gillespie J., Geard C.R., Amundson S.A., Brenner D.J., Yu Z., Lieberman H.B. and Hei T.K. Mechanism of radiation-induced bystander effect: role of the cyclooxygenase-2 signaling pathway. PNAS 102:14641-14646 (2005) [abstract] [PDF]
Brenner D.J. Letter to the Editor: Is it time to retire the CTDI for CT quality assurance and dose optimization? Med. Phys. 32:3225-3226 (2005). [abstract] [PDF]
Belyakov O.V., Mitchell S.A., Parikh D., Randers-Pehrson G., Marino S.A., Amundson S.A., Geard C.R. and Brenner D.J. Biological effects in unirradiated human tissue induced by radiation damage up to 1 mm away. PNAS 102:14203-14208 (2005) [abstract] [PDF]
Sachs R.K. and Brenner D.J. Solid tumor risks after high doses of ionizing radiation. PNAS 102:13040-13045 (2005). [abstract] [PDF]
Brenner D.J. and Georgsson M.A. Mass Screening With CT Colonography: Should the radiation exposure be of concern? Gastroenterology 129:328-337 (2005). [abstract] [PDF]
Hall E.J., Brenner D.J., Worgul B. and Smilenov L. Genetic susceptibility to radiation. Adv. Space Res. 35:249-253 (2005). [abstract] [PDF]
Hande M.P., Azizova T.V., Burak L.E., Khokhryakov V.F., Geard C.R. and Brenner D.J. Complex chromosome aberrations persist in individuals many years after occupational exposure to densely ionizing radiation: An mFISH study. Genes Chromosomes Cancer 44:1-9 (2005). [abstract] [PDF]
Vives S., Loucas B., Vazquez M., Brenner D.J., Sachs R.K., Hlatky L., Cornforth M., Arsuaga J. SCHIP: statistics for chromosome interphase positioning based on interchange data. Bioinformatics 21:3181-3182 (2005). [abstract] [PDF]
Worgul B.V., Smilenov L., Brenner D.J., Vazquez M., Hall E.J. Mice heterozygous for the ATM gene are more sensitive to both X-ray and heavy ion exposure than are wildtypes. Adv. Space Res. 35:254-259 (2005). [abstract] [PDF]
Brenner D.J. and Elliston C.D. In response to Radiation risk of body CT: What to tell our patients and other questions. (R.E. Levatter) Radiology 234:968-970 (2005). [abstract] [PDF]
Brenner D.J. Fractionation and late rectal toxicology. Int. J. Radiat. Oncol. Biol. Phys. 60:1013-1015 (2004). [abstract] [PDF]
Ponnaiya B., Jenkins-Baker G., Brenner D.J., Hall E.J., Randers-Pehrson G. and Geard C.R. Biological responses in known bystander cells relative to known microbeam-irradiated cells. Radiat. Res. 162:426-432 (2004). [abstract] [PDF]
Mitchell C.R., Azizova T.V., Hande M.P., Burak L.E., Tsakok J.M., Khokhryakov V.F., Geard C.R. and Brenner D.J. Stable intrachromosomal biomarkers of past exposure to densely ionizing radiation in several chromosomes of exposed individuals. Radiat. Res. 162:257-263 (2004). [abstract] [PDF]
Arsuaga J., Greulich-Bose K.M., Vazquez M., Bruckner M., Hahnfeldt P., Brenner D.J., Sachs R. and Hlatky L. Chromosome spatial clustering inferred from radiogenic aberrations. Int. J. Radiat. Biol. 80:507-515 (2004). [abstract] [PDF]
Brenner D.J. and Elliston C.D. Estimated radiation risks potentially associated with full-body CT screening. Radiology 232:735-738 (2004). [abstract] [PDF]
Mitchell S.A., Marino S.A., Brenner D.J. and Hall E.J. Bystander effect and adaptive response in C3H 10T½ cells. Int. J. Radiat. Biol. 80:465-472 (2004). [PDF]
Brenner D.J. and Hall E.J. Risk of cancer from diagnostic X-rays. Lancet 363:2192 (2004). [abstract] [PDF]
Brenner D.J. Radiation risks potentially associated with low-dose CT screening of adult smokers for lung cancer. Radiology 231:440-445 (2004). [abstract] [PDF]
Mitchell S.A., Randers-Pehrson G., Brenner D.J. and Hall E.J. The Bystander Response in C3H 10T(1/2) Cells: The Influence of Cell-to-Cell Contact. Radiat. Res. 161:397-401 (2004). [abstract] [PDF]
Bigelow A.W., Randers-Pehrson G. and Brenner D.J. Proposed laser ion source for the Columbia University microbeam. Nucl. Instrum. Methods Phys. Res. B 210:65-69 (2003).[PDF]
Brenner D.J., Doll R., Goodhead D.T., Hall E.J., et al. Cancer risks attributable to low doses of ionizing radiation: Assessing what we really know. Proc. Natl. Acad. Sci. USA 100:13761-13766 (2003). [abstract] [PDF]
Brenner D.J. Hypofractionation for prostate cancer radiotherapy––what are the issues? Int. J. Radiat. Oncol. Biol. Phys. 57:912-914 (2003). [abstract] [PDF]
Zhou H., Randers-Pehrson G., Geard C.R., Brenner D.J., Hall E.J. and Hei T.K. Interaction between radiation-induced adaptive response and bystander mutagenesis in mammalian cells. Radiat. Res. 160:512-516 (2003). [abstract] [PDF]
Hall E.J. and Brenner D.J. The weight of evidence does not support the suggestion that exposure to low doses of X rays increases longevity. Radiology 229:18-19 (2003). [abstract] [PDF]
Fowler J.F., Ritter M.A., Chappell R.J. and Brenner D.J. What hypofractionated protocols should be tested for prostate cancer? Int. J. Radiat. Oncol. Biol. Phys. 56:1093-1104 (2003). [abstract] [PDF]
Brenner D.J. and Sachs R.K. Domestic radon risks may be dominated by bystander effects- But the risks are unlikely to be greater than we thought. Heath Phys 85:103-108 (2003). [abstract] [PDF]
Hande M.P., Azizova T.V., Geard C.R., Burak L.E., Mitchell C.R., Khokhryakov V.F., Vasilenko E.K. and Brenner D.J. Past exposure to densely ionizing radiation leaves a unique permanent signature in the genome. Am. J. Hum. Genet. 72:1162-1170 (2003). [abstract] [PDF]
Brenner D.J. and Hall E.J. Mortality patterns in British and US radiologists: what can we really conclude? BJR 76:1-2 (2003). [abstract] [PDF]
Cornforth M.N., Greulich-Bode K.M., Loucas B.D., Arsuaga J., Vázquez M., Sachs R.K., Brückner M., Molls M., Hahnfeldt P., Hlatky L. and Brenner D.J. Chromosomes are predominantly located randomly with respect to each other in interphase human cells. J. Cell Biol. 159:237-244 (2002). [abstract] [PDF]
Brenner D.J., Sawant S.G., Hande M.P., Miller R.C., Elliston C.D., Fu Z., Randers-Pehrson G. and Marino SA. Routine screening mammography: how important is the radiation-risk side of the benefit-risk equation? Int. J. Radiat. Biol. 78:1065-1067 (2002) [abstract] [PDF]
Brenner D.J. and Hall E.J. Microbeams: a potent mix of physics and biology. Summary of the 5th International Workshop on Microbeam Probes of Cellular Radiation Response. Radiat. Prot. Dosimetry 99:283-286 (2002) [abstract] [PDF]
Worgul B.V., Smilenov L., Brenner D.J., Junk A., Zhou W. and Hall E.J. Atm heterozygous mice are more sensitive to radiation-induced cataracts than are their wild-type counterparts. Proc. Natl. Acad. Sci. USA 99:9836-9839 (2002). [abstract] [PDF]
Brenner D.J. and Sachs R.K. Do low dose-rate bystander effects influence domestic radon risks? Int. J. Radiat. Biol. 78:593-604 (2002). [abstract] [PDF]
Brenner D.J., Martinez A.A., Edmundson G.K., Mitchell C., Thames H.D. and Armour E.P. Direct evidence that prostate tumors show high sensitivity to fractionation (low a/b ratio), similar to late-responding normal tissue. Int. J. Radiat. Oncol. Biol. Phys. 52:6-13 (2002). [abstract] [PDF]
Brenner D.J., Martinez A.A., Edmundson G.K., Mitchell C., Thames H.D. and Armour E.P. In response to Dr. Lee. Int. J. Radiat. Oncol. Biol. Phys. 53:1393 [abstract] [PDF]
Brenner D.J. Estimating cancer risks from pediatric CT: Going from the qualitative to the quantitative.. Pediatr. Radiol. 32:228-231 (2002). [abstract] [PDF]
Brenner D.J. and Elliston C.D. The potential impact of bystander effects on radiation risks in a Mars mission. Radiat. Res. 156:612-617 (2001). [abstract] [PDF]
Brenner D.J., Elliston C.D., Hall E.J. and Berdon W.E. Estimated risks of radiation-induced fatal cancer from pediatric CT. AJR 176:289-296 (2001). [abstract] [PDF]
Brenner D.J. and Hall E.J. Dose rate does matter in endovascular brachytherapy. Cardiovasc. Radiat. Med. 2:254-255 (2001). [abstract] [PDF]
Brenner D.J., Little J.B. and Sachs R.K. The bystander effect in radiation oncogenesis II. A quantitative model. Radiat. Res. 155:402-408 (2001). [abstract] [PDF]
Brenner D.J. and Miller R.C. Long-term efficacy of intracoronary irradiation in inhibiting in-stent restenosis. Circulation 103:1330-1332 (2001). [abstract] [PDF]
Brenner D.J., Okladnikova N., Hande P., Burak L., Geard C.R. and Azizova T. Biomarkers specific to densely-ionising (high LET) radiations. Radiat. Prot. Dosimetry 97:69-73 (2001). [abstract] [PDF]
Brenner D.J. and Raabe O.G. Topics Under Debate: Is the Linear-No-Threshold Hypothesis Appropriate for Use in Radiation Protection? Radiat. Prot. Dosim. 97: 279-285 (2001). [abstract] [PDF]
Ponomarev A.L., Cucinotta F.A., Sachs R.K., Brenner D.J. and Peterson L.E. Extrapolation of the DNA fragment-size distribution after high-dose irradiation to predict effects at low doses. Radiat. Res. 156:594-597 (2001). [abstract] [PDF]
Ponomarev A.L., Cucinotta F.A., Sachs R.K. and Brenner D.J. Monte Carlo predictions of DNA fragment-sized distributions for large sizes after HZE particle irradiation. Phys. Med. 17:153-6 Suppl. (2001). [abstract] [PDF]
Randers-Pehrson G., Geard C.R., Johnson G., Elliston C.D. and Brenner D.J. The Columbia University single-ion microbeam. Radiat. Res. 156:210-214 (2001). [abstract] [PDF]
Sawant S.G., Randers-Pehrson G., Geard C.R., Brenner D.J. and Hall E.J. The bystander effect in radiation oncogenesis I. Transformation in C3H 10T1/2 cells in vitro can be initiated in the unirradiated neighbors of irradiated cells. Radiat. Res. 155:397-401 (2001). [abstract] [PDF]
Smilenov L.B., Brenner D.J. and Hall E.J. Modest increased sensitivity to radiation oncogenesis in ATM heterozygous versus wild-type mammalian cells. Cancer Res. 61:5710-5713 (2001). [abstract] [PDF]
Brenner D.J. Rutherford, the Curies, and Radon. Med. Phys. 27:618 (2000). [abstract] [PDF]
Brenner D.J. Towards optimal external-beam fractionation for prostate cancer. Int. J. Radiat. Oncol. Biol. Phys. 48:315-316 (2000). [abstract] [PDF]
Brenner D.J., Curtis R.E., Hall E.J. and Ron E. Second Malignancies in Prostate Cancer Patients After Radiotherapy Compared to Surgery. Cancer 88:398-406 (2000). [abstract] [PDF]
Brenner D.J. and Sachs R.K. Protraction effects in radiation studies: basic biophysics. Radiat. Res. 156:736-737 (2000). [abstract] [PDF]
Brenner D.J., Schiff P.B. and Zablotska L.B. Adjuvant radiotherapy for DCIS. Lancet 355:2071 (2000). [abstract] [PDF]
Dymnikov A.D., Brenner D.J., Johnson G. and Randers-Pehrson G. Theoretical study of short electrostatic lens for the Columbia ion microprobe. Rev. Sci. Instr. 71:1646-1650 (2000). [abstract] [PDF]
Miller R.C., Marino, S.A., Napoli J., Shah H., Hall, E.J., Geard C.R. and Brenner D.J. Oncogenic transformation in C3H10T½ cells by low-energy neutrons. Int. J. Radiat. Biol. 76:327-334 (2000). [abstract] [PDF]
Ponomarev A.L., Brenner D.J., Hlatky L.R., and Sachs R.K. A polymer, random walk model for the size-distribution of large DNA fragments after high linear energy transfer radiation. Radiat. Environ. Biophys. 39:111-120 (2000). [abstract] [PDF]
Brenner D.J. Does fractionation decrease the risk of breast cancer induced by low-LET radiation? Radiat. Res. 151:225-229 (1999). [abstract] [PDF]
Brenner D.J. The relative effectiveness of exposure to 131I at low doses. Health Phys. 76:180-185 (1999). [abstract]
Brenner D.J. and Hall E.J. Fractionation and protraction for radiotherapy of prostate carcinoma. Int. J. Radiat. Oncol. Biol. Phys. 43:1095-1101 (1999). [abstract] [PDF]
Brenner D.J., Leu C-S, Beatty J.F., and Shefer R.E. Clinical relative biological effectiveness of low-energy x-ray emitted by miniature x-ray devices. Phys. Med. Biol. 44:323-333 (1999). [abstract] [PDF]
Brenner D.J. and Sachs R.K. A more robust biologically based ranking criterion for treatment plans. Int. J. Radiat. Oncol. Biol. Phys. 43:697-698 (1999). [abstract] [PDF]
Hall E.J., Miller R.C. and Brenner D.J. Radiobiological principles in intravascular irradiation. Cardiovasc. Radiat. Med. 1:42-47 (1999). [abstract] [PDF]
Johnson K.L., Brenner D.J., Geard C.R., Nath J., and Tucker J.D. Chromosome aberrations of clonal origin in irradiated and unexposed individuals: Assessment and implications. Radiat. Res. 152:1-5 (1999). [abstract] [PDF]
Johnson K.L., Brenner D.J., Nath J., Tucker J.D., and Geard C.R. Radiation-induced breakpoint misrejoining in human chromosomes: Random or non-random? Int. J. Radiat. Biol. 75:131-141 (1999). [abstract] [PDF]
Miller R.C., Marino S.A., Martin S.G., Komatsu K., Geard C.R., Brenner D.J. and Hall E.J. Neutron-energy-dependent cell survival and oncogenic transformation. J. Radiat. Res. 40:53-59 Suppl (1999). [abstract] [PDF]
Miller R.C., Randers-Pehrson G., Geard C.R., Hall E.J., and Brenner D.J. The oncogenic transforming potential of the passage of single alpha particles through mammalian cell nuclei. Proc. Nat. Acad. Sci. USA 96:18-22 (1999). [abstract] [PDF]
Smith L.G., Miller R.C., Richards M., Brenner D.J. and Hall E.J. Investigation of hypersensitivity to fractionated low-dose radiation exposure. Int. J. Radiat. Oncol. Biol. Phys. 45:187-191 (1999). [abstract] [PDF]
Brenner D.J. and Zaider M. Estimating RBEs at clinical doses from microdosimetric spectra. Med Phys. 25:1055-1057 (1998). [abstract] [PDF]
Brenner D.J., Hlatky L.R., Hahnfeldt P.J., Huang Y., and Sachs R.K. The linear-quadratic model and most other common radiobiological models result in similar predictions of time-dose relationships. Radiat. Res. 150:83-91 (1998). [abstract] [PDF]
Brenner D.J., Lubin, J.H. and Ron E. Moving from under the lamppost: can epidemiologists and radiobiologists work together? Nucl Med 37:25-31 (1998). [abstract] [PDF]
Hall E.J., Schiff P.B., Hanks G.E., Brenner D.J., Russo J., Chen J. Sawant S.G., and Pandita T.K. A preliminary report: Frequency of A-T heterozygotes among prostate cancer patients with severe late responses to radiation therapy. Cancer J. Sci. Am. 4:385-389 (1998). [abstract]
Randers-Pehrson G. and Brenner D.J. A practical target system for accelerator-based BNCT which may effectively double the dose rate. Med. Phys. 25:894-6 (1998). [abstract] [PDF]
Sachs R.K., Brenner D.J., Hahnfeldt P.J. and Hlatky L.R. A formalism for analysing large-scale clustering of radiation-induced breaks along chromosomes. Int. J. Radiat. Biol. 74:185-206 (1998). [abstract] [PDF]
Brenner D. J. Radiation biology in brachytherapy. J. Surg. Oncol. 65:66-70 (1997). [abstract] [PDF]
Brenner D.J., Schiff P.B., Huang Y., and Hall E.J. Pulsed dose-rate (PDR) brachytherapy: Design of convenient (daytime only) schedules. Int. J. Radiat. Oncol. Biol. Phys. 39: 809-815 (1997). [abstract] [PDF]
Sachs R.K., Hahnfeld P., and Brenner D.J. Review: The link between low-LET dose-response relations and the underlying kinetics of damage production/repair/misrepair. Int. J. Radiat. Biol. 72:351-374 (1997). [abstract] [PDF]
Sachs R.K., Chen A.M., and Brenner D.J. Review: Proximity effects in the production of chromosome aberrations by ionizing radiation. Int. J. Radiat. Biol. 71:1-19 (1997). [abstract] [PDF]
Brenner D.J. Direct biological evidence for a significant neutron dose to survivors of the hiroshima A bomb. Radiat. Res. 145:501-507 (1996). [abstract] [PDF]
Brenner D.J., Hall E.J., Randers-Pehrson G., Huang Y., Johnson G.W., Miller R.W., Wu B., Vazquez M.E., Medvedovsky C. and Worgul B.V. Quantitative comparisons of continuous and pulsed low dose-rate regimens in a model late-effect system. Int. J. Radiat. Oncol. Biol. Phys. 34:905-910 (1996). [abstract] [PDF]
Brenner D.J., Hlatky L.R., Hahnfeldt P.J., Hall E.J., and Sachs R.K. A convenient extension of the linear-quadratic model to include redistribution and reoxygenation. Int. J. Radiat. Oncol. Biol. Phys. 32:379-390 (1995). [abstract] [PDF]
Brenner D.J., Miller R.C., Huang Y. and Hall E.J. The biological effectiveness of radon-progeny aplha particles. III. Quality factors. Radiat. Res. 142:61-69 (1995). [abstract] [PDF]
Brenner D.J. and Sachs R.K. Chromosomal 'fingerprints' of prior exposure to densely-ionizing radiation. Radiat. Res. 140:134-142 (1994). [abstract] [PDF]
Brenner D.J., Hall E.J., Huang Y.P., and Sachs R.K. Optimizing the time course of brachytherapy and other accelerated radiotherapeutic protocols. Int. J. Radiat. Oncol. Biol. Phys. 29:893-901 (1994). [abstract]
Brenner D.J. The significance of dose rate in assessing the hazards of domestic radon exposure. Health Physics 67:76-79 (1994). [abstract]
Hahnfeldt P., Hearst J.E., Brenner D.J., Sachs R.K., and Hlatky L.R. Polymer models for interphase chromosomes. Proc. Nat. Acad. Sci. USA 90:7854-7858 (1993). [abstract] [PDF]
RADIOLOGICAL SCIENCE IN THE CONTEXT OF RADIOLOGICAL TERRORISM
- Series of podcast based on a CME training course of the same name
- Features lectures from Eric Hall, Charles Geard, Sally Amundson, John Little, Joseph Ring, and Karestan Koenen in addition to David Brenner
- Audio and slides of all lectures are available at no charge
2008 Health Physics Society Morgan Lecture "Potential Risks Associated with CT Scans: Should we be Concerned? (Brenner-Morgan.ppt 22 MB, Powerpoint)
RADIOLOGICAL TERRORISM: WHAT IS IT? ARE WE PREPARED? (rddmethodist.ppt, 10.2 MB, Powerpoint)
Radiation-induced cancer risks from pediatric CT (ctrsna.ppt, 6.1 MB, Powerpoint)
Environmental Health Sciences Core Course: Ionizing Radiation plus Radon
- Download the slide show radlecture_radon.ppt here. (7.2 MB, Powerpoint).
Environmental Health Sciences Core Course: Ionizing Radiation plus Radiological Terrorism
- Download the slide show radlecturet.ppt here. (10.1 MB, Powerpoint).
Depleted Uranium (du.ppt, 12 MB, Powerpoint)
Other Publications of Interest
Is that imaging test really needed?, Consumer Reports, June 2008.
Take the A, C, or 1 subway train to West 168th Street. From the corner of 168th Street and Broadway, walk 1/2 block west along 168th Street to 630 West 168th Street (College of Physicians and Surgeons).
Check in with the guard, tell them you are visiting David Brenner (internal phone 5-5660). Get a pass, take the elevators up to the 11th floor. You'll be faced with a long corridor. Turn left at the corridor, walk all the way to the end, and stop at VC 11-230 (on the left).
Click on the map above
for an interactive map of the area.
David Brenner
Center for Radiological Research
VC 11-230
630 W. 168th St.
New York, NY 10032The map was provided by Mapquest.
This page was last updated October 1, 2009 .