Epidemiology and Comorbidity of Psychiatric and Substance Use Disorders
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Research in this area has been conducted in clinical and general population samples.
In prospectively followed drug and alcohol patients, full syndromes of major depression clearly exceeding the expected effects of intoxication and/or withdrawal predict failure to remit from cocaine, heroin and/or alcohol dependence, while major depression during sustained abstinence is a risk factor for relapse of cocaine, heroin and/or alcohol dependence.
Among former drinkers in the general population, a history of alcohol dependence while they were drinkers predicts increased risk for current major depressive disorder.
Antisocial, borderline and schizoptypal personality disorders predict poor course of alcohol, cannabis and nicotine disorders in the U.S. general population, suggesting consideration of a broad range of personality disorders in understanding substance use disorders
Topics of current investigation in this area include the relationship of personality and Axis I disorders, particularly substance use disorders. Comorbidity research has been supported by the National Institute on Alcohol Abuse and Alcoholism (NIAAA) and the National Institute on Drug Abuse (NIDA).
Hasin D, Fenton MC, Skodol A, Keyes K, Geier T, Greenstein E, Blanco C, Grant BF: Relationship
of personality disorders to the three-year course of alcohol, cannabis and nicotine disorders
in the United States. In press, Archives of General Psychiatry.
Eaton NR, Krueger RF, Keyes KM, Skodol AE, Markon KE, Grant BF, Hasin DS: Borderline personality disorder co-morbidity: relationship to the internalizing-externalizing structure of common mental disorders. Psychol Med 41(5):1041-50, 2011. PDF
Skodol AE, Grilo CM, Keyes KM, Geier T, Grant BF, Hasin DS: Relationship of personality disorders to the course of major depressive disorder in a nationally representative sample. Am J Psychiatry 168(3):257-64, 2011. PDF
Hasin DS, Stinson FS, Ogburn E, Grant BF: Prevalence, correlates, disability, and comorbidity of DSM-IV alcohol abuse and dependence in the United States: results from the National Epidemiologic Survey on Alcohol and Related Conditions. Arch Gen Psychiatry 64(7):830-42, 2007. PDF
Hasin DS, Goodwin RD, Stinson FS, Grant BF: Epidemiology of major depressive disorder: results from the National Epidemiologic Survey on Alcoholism and Related Conditions. Arch Gen Psychiatry 62(10):1097-106, 2005. PDF
Caton C, Drake RE, Hasin D, Dominguez B, Shrout PE, Samet S, Schanzer B. Differences between early phase primary psychotic disorders with concurrent substance use and substance-induced psychoses. Arch Gen Psychiatry 62:137-145, 2005. PDF
Grant BF, Hasin D, Chou SP, Stinson FS, Dawson DA. Nicotine dependence and psychiatric disorders in the US: results from the national epidemiologic survey on alcohol and related conditions. Arch Gen Psychiatry 61:1107-1115, 2004. PDF
Hasin D, Grant B: Major depression in 6,050 former drinkers: association with past alcohol dependence. Archives of General Psychiatry 59:794-800, 2002. PDF
Hasin D, Liu X-H, Nunes E, McCloud S, Samet S, Endicott J: Effects of major depression on remission and relapse of substance dependence. Archives of General Psychiatry 59:375-380, 2002. PDF
Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: Five-year course of major depression: Effects of comorbid alcoholism. Journal of Affective Disorders 41:63-70, 1996. PDF
Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: The effects of major depression on alcoholism: five-year course. American Journal on Addictions 5:144-155, 1996. PDF
Hasin D, Endicott J, Keller MB: RDC alcoholism in patients with major affective syndromes: 2-year course. American Journal of Psychiatry 146:318-323, 1989. PDF
Hasin D, Endicott J, Lewis C: Alcohol and drug abuse in patients with affective syndromes. Comprehensive Psychiatry 26:283-295, 1985. PDF
Choose another research area: Adolescent substance use
Alcohol and nicotine use disorders in Israel
Measurement issues in substance use and psychiatric disorders
Natural history of substance use disorders
State-level influences on drug, alcohol and psychiatric conditions
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