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Comorbidity of Psychiatric and Substance Use Disorders |
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Research in this area has been conducted in several clinical and general population samples, and has largely focused on the relationship of major depression and alcohol and drug use disorders to each other.
Findings from this research include:
Among patients with both major depression and alcoholism, relapses and remissions in each disorder affect the other disorder.
In a follow-up study of hospitalized drug and alcohol patients, full syndromes of major depression clearly exceeding the expected effects of intoxication and/or withdrawal predict failure to remit from cocaine, heroin and/or alcohol dependence.
Major depression with lifetime onset prior to the earliest onset of cocaine, heroin and/or alcohol dependence prospectively predicts failure to remit from current episodes of alcohol, cocaine or heroin dependence disorders.
Major depression during sustained abstinence is a risk factor for relapse of cocaine, heroin and/or alcohol dependence.
Periods of major depression during sustained abstinence are a risk factor for increased number of suicide attempts over the lifetime. Major depression with onset before the onset of substance dependence predicts severity of suicidal intent.
A history of alcohol dependence in former drinkers in the general population predicts major depressive disorder, as compared to former drinkers without a history of alcohol dependence.
Both primary and substance-induced major depression in substance abusers prospectively predict ongoing problems with depression, even when substance use is controlled.
Topics of current investigation in this area include predictors of the outcome of major depression in these patients, and identification of factors that potentiate the effects of depression during abstinence on relapse of substance dependence and suicide attempts. This research is supported by the National Institute on Drug Abuse (NIDA) and the National Institute on Alcohol Abuse and Alcoholism (NIAAA).
Selected Publications:
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Hasin D, Goodwin R, Stinson F, Grant BF: The epidemiology of major depressive disorder: results from
the National Epidemiologic Survey on Alcohol and Related Conditions. In press, Arch Gen Psychiatry.
Grant B, Stinson F, Hasin D, Dawson D, Chou P, Ruan J, Huang B; Prevalence, Correlates and Comorbidity of Bipolar I Disorder and Axis I and II Disorders: Results from the National Epidemiologic Survey on Alcohol and Related Conditions. In press, J Clin Psychiatry. Meydan J, Liu X, Hasin D: Alcohol and drug use in schizophrenia as predictors of functional impairment. In press, Schizophrenia Research.
Caton C, Drake RE, Hasin D, Dominguez B, Shrout PE, Samet S, Schanzer B. Differences between early phase primary psychotic disorders with concurrent substance use and substance-induced psychoses. Arch Gen Psychiatry. 62:137-145, 2005. Grant BF, Hasin DS, Stinson FS, Dawson DA, Patricia Chou S, June Ruan W, Huang B. Co-occurrence of 12-month mood and anxiety disorders and personality disorders in the US: results from the national epidemiologic survey on alcohol and related conditions. J Psychiatr Res. 2005 Jan;39(1):1-9. Grant BF, Stinson FS, Hasin D, Dawson DA, Chou SP: Immigration and lifetime prevalence of DSM-IV psychiatric disorders among Mexican Americans and non-Hispanic whites in the US: results from the NESARC. Arch Gen Psychiatry 61:1226-1233, 2004. Grant BF, Hasin D, Chou SP, Stinson FS, Dawson DA. Nicotine dependence and psychiatric disorders in the US: results from the NESARC. Arch Gen Psychiatry 61:1107-1115, 2004. Grant BF, Stinson FS, Hasin D, Dawson DA, Chou SP, Ruan WJ, Pickering RP: Prevalence, correlates, and disability of personality disorders in the U.S.: results from the NESARC. J Clin Psychiatry 65:948-958, 2004. Samet S, Hasin D, Nunes E: Diagnosing comorbidity: concepts, criteria, and methods: a review. Acta Neuropsychiatrica, 16:9-18,2004. Hasin D, Nunes E, Meydan J: "Epidemiology: Comorbidity of Substance Use and Psychiatric Disorders." In: Dual Diagnosis and Treatment, eds. H.R. Kranzler and J.A. Tinsley; Marcel Dekker, Inc, 2004. Aharonovich E, Nunes E, Hasin D: Cognitive impairment, retention and abstinence among cocaine abusers in cognitive-behavioral treatment. Drug and Alcohol Dependence 71:207-211, 2003. Nunes EV, Liu X, Samet S, Matseoane K, Hasin D: Primary vs. substance-induced major depression in substance-dependent patients: course during follow-up. Submitted. Hasin D, Grant B: Major depression in 6,050 former drinkers: association with past alcohol dependence. Archives of General Psychiatry 59:794-800, 2002.PDF Aharonovich E, Liu X, Nunes E, Hasin D: Suicide attempts in substance abusers: Effects of major depression in relation to substance use disorders. American Journal of Psychiatry 159:1600-1602, 2002.PDF Hasin D, Liu X-H, Nunes E, McCloud S, Samet S, Endicott J: Effects of major depression on remission and relapse of substance dependence. Archives of General Psychiatry 59:375-380, 2002.PDF Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: Five-year course of major depression: Effects of comorbid alcoholism. Journal of Affective Disorders 41:63-70, 1996. Hasin D, Tsai W-Y, Endicott J, Muller T, Coryell W, Keller M: The effects of major depression on alcoholism: five-year course. American Journal on Addictions 5:144-155, 1996. PDF Hasin D, Endicott J, Keller MB: RDC alcoholism in patients with major affective syndromes: 2-year course. American Journal of Psychiatry 146:318-323, 1989. Hasin D, Endicott J, Lewis C: Alcohol and drug abuse in patients with affective syndromes. Comprehensive Psychiatry 26:283-295, 1985. |
Choose another research area: Genetics and epidemiology of alcohol consumption and dependence symptoms in Israel
Natural history of alcohol use disorders
Measurement issues in substance use and psychiatric disorders
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Tel. (212) 543-5035 |
E-mail: dsh2@columbia.edu |