Natural History of Substance Use Disorders
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This work has encompassed prospective longitudinal research with treated and untreated national and community samples, with follow-ups ranging from 1 to 10 years. This research has been supported by the National Institute on Alcohol Abuse and Alcoholism ( NIAAA ) and the National Institute on Drug Abuse ( NIDA ).
(See Epidemiology and comorbidity of psychiatric and substance use disorders for studies of the relationship between psychiatric disorders and the prospective course of substance use disorders)
Findings from this research include:
Many cases of alcohol abuse remit naturally without developing into cases of dependence, indicating that abuse is not merely a prodromal stage of dependence.
A family history of alcohol problems, alcohol withdrawal symptoms, and a heavy drinker in the household (related or unrelated) predict chronicity of DSM-IV alcohol dependence.
Drinking to cope with negative affect predicts first-time occurrence of DSM-IV alcohol dependence after one and ten years of follow-up, but does not predict DSM-IV alcohol abuse.
Cannabis use predicted poor course of treated cocaine, alcohol and heroin abusers.
Baseline drinking motives (coping, enjoyment) predicted increased drinking ten years later after exposure to the events of September 11, 2001.
Topics of current investigation in this area include investigation of the onset of alcohol dependence and likelihood of chronic heavy drinking and alcohol use disorders among subjects not in treatment.
Beseler CL, Aharonovich E, Keyes KM, Hasin DS: Adult transition from at-risk drinking to alcohol dependence: the
relationship of family history and drinking motives. Alcohol Clin Exp Res 32(4):607-16, 2008.
Aharonovich E, Liu X, Samet S, Nunes E, Hasin D: Postdischarge cannabis use and its relationship to cocaine, alcohol and heroin use: a prospective study. Am J Psychiatry 162(8):1507-14, 2005. PDF
Hasin D: Still difficult to know what alcohol dependent individuals can return to controlled drinking: comments on Dawson et al. (2005). Addiction 100(3):295-6, 2005. PDF
Hasin D, Paykin A, Endicott J: Course of DSM-IV alcohol dependence in a community sample: effects of parental history and binge drinking. Alcoholism: Clinical and Experimental Research 25: 411-414, 2001. PDF
Hasin D, Paykin A, Meydan K, Grant B: Withdrawal and tolerance: prognostic significance in DSM-IV alcohol dependence. Journal of Studies on Alcohol 61(3):431-438, 2000. PDF
Hasin D, Carpenter KM, Paykin A: At-risk drinkers in the household and short-term course of alcohol dependence. Journal of Studies on Alcohol 60(6):769-75, 1999. PDF
Carpenter K, Hasin D: A prospective evaluation of the relationship between reasons for drinking and DSM-IV alcohol use disorders. Addictive Behaviors 23: 41-46, 1998. PDF
Hasin D, Van Rossem R, McCloud S, Endicott J: Differentiating DSM-IV alcohol dependence and abuse by course: community heavy drinkers. Journal of Substance Abuse 9:127-135, 1997. PDF
Hasin D, Grant BF, Endicott J: The natural history of alcohol abuse; implications for definitions of alcohol use disorders. American Journal of Psychiatry 147:1537-1541, 1990. PDF
Choose another research area: Adolescent substance use
Alcohol and nicotine use disorders in Israel
Epidemiology and comorbidity of psychiatric and substance use disorders
Measurement issues in substance use and psychiatric disorders
State-level influences on drug, alcohol and psychiatric conditions
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