Lesson 5: Profile Analysis

PSIBLAST and DELTABLAST

Prosite Profiles

Meme and a Motifsearch-like program called Mast

Blocks database

SMART database

Interpro: Combined protein sequence and motif site

CD-Search: Searches libraries of profiles

DART: Gives block domain diagrams of protein and its homologs

SUPERFAMILY: Classifies Proteins According to Superfamily

Clustal to Stockholm conversion

Hmmscan: Searches sequence against Hidden Markov Model protein family database

Phmmer: Searches sequence against sequence database by means of hidden Markov models

Hmmsearch: Searches multiple sequence alignment against sequence database by means of hidden Markov models

Jackhmmer: Iterative hidden Markov model search

SH2 Meme result

SH2 Domains aligned by T-Coffee in Clustal format

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