I am a bioinformatics analyst in Shen lab in the Department of Systems Biology at Columbia University and in Dr. Wendy Chung’s lab at Boston Children’s Hospital. I work at the interface of computational genomics and human genetics, focusing on rare, early-onset diseases.

My work centers on three main areas in computational genomics: (1) using selection-based metrics and large-scale sequencing data to prioritize candidate pathogenic variants in early-onset diseases, especially in singleton and duo families where parental genotypes are unavailable; (2) building scalable pipelines for variant calling, quality control, and functional annotation that support both rare disease studies and resources such as Mutable.wiki, a public gene-centric database of curated de novo variants; and (3) leading computational analyses for a polymorphism-targeted antisense oligonucleotide (ASO) program in KIF1A-associated neurological disorder, using long-read sequencing data to determine cis phase between pathogenic variants and common polymorphisms and to identify shared targetable sites across patients.

I completed my B.S. and M.S. in Electrical Engineering at Beijing Jiaotong University and Columbia University, respectively, and I bring that engineering perspective into genomics by treating complex biological problems as structured, analyzable systems. I’m broadly motivated by biological questions that connect data analysis, statistical modeling, evolutionary constraint, and clinical impact.

Outside of work, I enjoy long-distance running and reading, especially Chinese wuxia and classic detective fiction. My favorite fictional characters are Linghu Chong and Miss Marple.