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Recent Contributions from the Leighton Group

72

"A Highly Step-Economical Synthesis of Dictyostatin" Ho, S.; Bucher, C.; Leighton, J. L. Angew. Chem. Int. Ed. doi: 10.1002/anie.201302565 [Link]


71

"A New and More Powerfully Activating Diamine for Practical and Scalable Enantioselective Aldehyde Crotylsilylation Reactions" Suen, L. M.; Steigerwald, M. L.; Leighton, J. L. Chemical Science 2013, 4, 2413-2417. [Link]


70

"Toward a More Step-Economical and Scalable Synthesis of Spongistatin 1 to Facilitate Cancer Drug Development Efforts" Reznik, S. K.; Leighton, J. L. Chemical Science 2013, 4, 1497-1501. [Link]


69

"Complex Fragment Coupling by Crotylation: A Powerful Tool for Polyketide Natural Product Synthesis" Reznik, S. K.; Marcus, B. S.; Leighton, J. L. Chemical Science 2012, 3, 3326-3330. [Link]

  Graphical
                              abstract: Complex fragment coupling by
                              crotylation: a powerful tool for
                              polyketide natural product synthesis

68

"An “Aprotic” Tamao Oxidation/Syn-Selective Tautomerization Reaction for the Efficient Synthesis of the C(1)–C(9) Fragment of Fludelone" Harrison, T. J.; Rabbat, P. M. A.; Leighton, J. L. Org. Lett. 2012, 14, 4890-4893. [Link]




67

"Direct and highly regioselective and enantioselective allylation of β-diketones" Chalifoux, W. A.; Reznik, S. K.; Leighton, J. L. Nature 2012, 487, 86-89. [Link]



Also see a Nature News & Views perspective on this work: "Organic chemistry: Reactions at the end of a tether" Roesner, S.; Aggarwal, V. K. Nature 2012, 487, 48-49. [Link]


66

"A Tandem Cross-Metathesis/Semipinacol Rearrangement Reaction" Plummer, C. W.; Soheili, A.; Leighton, J. L. Org. Lett. 2012, 14, 2462-2464. [Link]


65

"Direct and Highly Enantioselective Iso-Pictet–Spengler Reactions with α-Ketoamides: Access to Underexplored Indole Core Structures" Schönherr, H.; Leighton, J. L. Org. Lett. 2012, 14, 2610-2613. [Link]


64

"A New Synthesis of Pyrrolidines by Way of an Enantioselective Mannich/Diastereoselective Hydroamination Reaction Sequence" Baxter Vu, J. M.; Leighton, J. L. Org. Lett. 2011, 13, 4056-4059. [Link]


63

"Toward More "Ideal" Polyketide Natural Product Synthesis: A Step-Economical Synthesis of Zincophorin Methyl Ester" Harrison, T. J.; Ho, S.; Leighton, J. L. J. Am. Chem. Soc. 2011, 133, 7308-7311. [Link]


62

"A More Comprehensive and Highly Practical Solution to Enantioselective Aldehyde Crotylation" Kim, H.; Ho, S.; Leighton, J. L. J. Am. Chem. Soc. 2011, 133, 6517-6520. [Link]


61

"Highly Enantioselective Mannich Reactions with α-Aryl Silyl Ketene Acetals and Imines" Notte, G. T.; Baxter Vu, J. M.; Leighton, J. L. Org. Lett 2011, 13, 816-818. [Link]

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Email: leighton@chem.columbia.edu



Maintained by Steven Schwartz | Last Updated: 11 May 2013