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Publications

72

"A Highly Step-Economical Synthesis of Dictyostatin" Ho, S.; Bucher, C.; Leighton, J. L. Angew. Chem. Int. Ed. doi: 10.1002/anie.201302565 [Link]


71

"A New and More Powerfully Activating Diamine for Practical and Scalable Enantioselective Aldehyde Crotylsilylation Reactions" Suen, L. M.; Steigerwald, M. L.; Leighton, J. L. Chemical Science 2013, 4, 2413-2417. [Link]


70

"Toward a More Step-Economical and Scalable Synthesis of Spongistatin 1 to Facilitate Cancer Drug Development Efforts" Reznik, S. K.; Leighton, J. L. Chemical Science 2013, 4, 1497-1501. [Link]


69

"Complex Fragment Coupling by Crotylation: A Powerful Tool for Polyketide Natural Product Synthesis" Reznik, S. K.; Marcus, B. S.; Leighton, J. L. Chemical Science 2012, 3, 3326-3330. [Link]

  Graphical
                            abstract: Complex fragment coupling by
                            crotylation: a powerful tool for polyketide
                            natural product synthesis

68

"An “Aprotic” Tamao Oxidation/Syn-Selective Tautomerization Reaction for the Efficient Synthesis of the C(1)–C(9) Fragment of Fludelone" Harrison, T. J.; Rabbat, P. M. A.; Leighton, J. L. Org. Lett. 2012, 14, 4890-4893. [Link]




67

"Direct and highly regioselective and enantioselective allylation of β-diketones" Chalifoux, W. A.; Reznik, S. K.; Leighton, J. L. Nature 2012, 487, 86–89. [Link]


66

"A Tandem Cross-Metathesis/Semipinacol Rearrangement Reaction" Plummer, C. W.; Soheili, A.; Leighton, J. L. Org. Lett. 2012, 14, 2462-2464. [Link]


65

"Direct and Highly Enantioselective Iso-Pictet–Spengler Reactions with α-Ketoamides: Access to Underexplored Indole Core Structures" Schönherr, H.; Leighton, J. L. Org. Lett. 2012, 14, 2610-2613. [Link]


64

"A New Synthesis of Pyrrolidines by Way of an Enantioselective Mannich/Diastereoselective Hydroamination Reaction Sequence" Baxter Vu, J. M.; Leighton, J. L. Org. Lett. 2011, 13, 4056-4059. [Link]


63

"Toward More "Ideal" Polyketide Natural Product Synthesis: A Step-Economical Synthesis of Zincophorin Methyl Ester" Harrison, T. J.; Ho, S.; Leighton, J. L. J. Am. Chem. Soc. 2011, 133, 7308-7311. [Link]


62

"A More Comprehensive and Highly Practical Solution to Enantioselective Aldehyde Crotylation" Kim, H.; Ho, S.; Leighton, J. L. J. Am. Chem. Soc. 2011, 133, 6517-6520. [Link]


61

"Highly Enantioselective Mannich Reactions with α-Aryl Silyl Ketene Acetals and Imines" Notte, G. T.; Baxter Vu, J. M.; Leighton, J. L. Org. Lett 2011, 13, 816-818. [Link]


60

"Enantioselective (Formal) Aza-Diels−Alder Reactions with Non-Danishefsky-Type Dienes" Tambar, U. K.; Lee, S. K.; Leighton, J. L. J. Am. Chem. Soc. 2010, 132, 10248–10250. [Link]


59

"Highly enantioselective formal aza-Diels–Alder reactions with acylhydrazones and Danishefsky's diene promoted by a silicon Lewis acid" Lee, S. K.; Tambar, U. K.; Perl, N. R.; Leighton, J. L. Tetrahedron 2010, 66, 4769-4774. [Link]


58

"Asymmetric Allylation, Crotylation, and Cinnamylation of N-Heteroaryl Hydrazones" Feske, M. I.; Buitrago Santanilla, A.; Leighton, J. L. Org. Lett. 2010, 12, 688-6919. [Link]


57

"Tandem Asymmetric Aza-Darzens/Ring-Opening Reactions: Dual Functionality from the Silane Lewis Acid" S. Corey Valdez; Leighton, J. L. J. Am. Chem. Soc. 2009, 131, 14638-14639. [Link]


56

"Highly Enantioselective Pictet-Spengler Reactions with α-Ketoamide-Derived Ketimines: Access to an Unusual Class of Quaternary α-Amino Amides"
Bou-Hamdan, F. R.; Leighton, J. L.
Angew. Chem. Int. Ed. 2009, 48, 2403-2406. [Link]


55

"Tandem Silylformylation-Crotylsilylation/Tamao Oxidation of Internal Alkynes: A Remarkable Example of Generating Complexity from Simplicity" Spletstoser, J. T.; Zacuto, M. J.; Leighton, J. L. Org. Lett. 2008, 10, 5593–5596. [Link]


54

"An Efficient Asymmetric Synthesis of Manzacidin C" Tran, K.; Lombardi, P. J.; Leighton, J. L. Org. Lett. 2008, 10, 3165-3167. [Link]


53

"A New Silicon Lewis Acid for Highly Enantioselective Mannich Reactions of Aliphatic Ketone-Derived Hydrazones" Notte, G. T.; Leighton, J. L. J. Am. Chem. Soc 2008, 130, 6676-6677. [Link]


52

"Allylsilane Vinylarene Cross-Metathesis Enables a Powerful New Approach to Enantioselective Imine Allylation" Huber, J. D.; Perl, N. R.; Leighton, J. L. Angew. Chem. Int. Ed. 2008, 47, Early View. [Link]


51

"Highly Enantioselective Imine Cinnamylation with a Remarkable Diastereochemical Switch" Huber, J. D.; Leighton, J. L. J. Am. Chem. Soc. 2007, 129(47), 14552-14553. [Link]


50

"Enantioselective Imidazole-Directed Allylation of Aldimines and Ketimines" Perl N. R.; Leighton, J. L. Org. Lett. 2007, 9, 3699-3701. [Link]


49

"A Modified Approach to the Phomoidrides: Synthesis of a Late-Stage Intermediate Containing a Key Carbon Quaternary Center" Castagner, B.; Leighton, J. L. Tetrahedron 2007, 63, 5895-5902. [Link]


48

"Phenol-Directed Enantioselective Allylation of Aldimines and Ketimines" Rabbat, P. M. A.; Valdez, S. C.; Leighton, J. L. Org. Lett. 2006, 7, 6119-6121. [Link]


47

"A Simple, Efficient, and Highly Enantioselective Synthesis of MS-153 Employing a Chiral Silane Lewis Acid-Promoted Acylhydrazone-Enol Ether [3+2] Cycloaddition" Tran, K.; Leighton, J. L. Adv. Synth. Catal. 2006, 348 2431. [Link]


46

"Strained Silacycle-Catalyzed Asymmetric Diels-Alder Cycloadditions: The First Highly Enantioselective Silicon Lewis Acid Catalyst" Kubota, K.; Hamblett, C. L.; Wang, X.; Leighton, J. L. Tetrahedron 2006, 62 11397-11401. [Link]


45

"A Method for the Enantioselective Allylation and Crotylation of Sterically Hindered and Functionalized Aryl Ketones: Convenient and Unprecedented Access to Unusual Tertiary Carbinol Structures" Burns, N. Z.; Hackman, B. M.; Ng, P. Y.; Powelson, I. A.; Leighton, J. L. Angew. Chem. Int. Ed. 2006, 45(23), 3811-3813. [Link]


44

"Total Synthesis of Dolabelide D" Park, P. K.; O'Malley, S. J.; Schmidt, D. R.; Leighton, J. L. J. Am. Chem. Soc. 2006, 128(9), 2796-2797. [Link]


43

"Divergent Synthesis of Complex Polyketide-Like Macrolides from a Simple Polyol Fragment" Zacuto, M. J.; Leighton, J. L. Org. Lett. 2005, 7, 5525-5527. [Link]


42

"Tandem Aldol-Allylation and Aldol-Aldol Reactions with Ketone-Derived Enolsilanes: Highly Diastereoselective Single-Step Synthesis of Complex Tertiary Carbinols" Wang, X.; Meng Q.; Perl N. R.; Xu Y.; Leighton J. L. J. Am. Chem. Soc 2005, 127(37), 12806-12807. [Link]


41

"Efficient Asymmetric Synthesis of (+)-SCH 351448" Bolshakov, S.; Leighton, J. L. Org. Let 2005, 7(17), 3809-3812. [Link]


40

"A Simple and General Chiral Silicon Lewis Acid for Asymmetric Synthesis: Highly Enantioselective [3+2] Acylhydrazone-Enol Ether Cycloadditions" Shirakawa, S.; Lombardi, P. J.; Leighton, J. L. J. Am. Chem. Soc. 2005, 127, 9974-9975. [Link]


39

"Enantioselective Friedel-Crafts Alkylations with Benzoylhydrazones Promoted by a Simple Strained Silacycle Reagent" Shirakawa, S.; Berger, R.; Leighton, J. L. J. Am. Chem. Soc. 2005, 127, 2858-2859. [Link]


38

"Origins of Stereoselectivity in Strain-Release Allylations" Zhang, X.; Houk, K. N.; Leighton, J. L. Angew. Chem. Int. Ed. 2005, 44, 938-941. [Link]


37

"Highly Diastereo- and Enantioselective Reagents for Aldehyde Crotylation" Hackman, B. M.; Lombardi, P. J.; Leighton J.L. Org. Lett. 2004, 6, 4375-4377. [Link]


36

"Enantioselective Cu-Catalyzed Conjugate Addition of Diethylzinc to Acyclic Aliphatic Enones" Duncan, A. P.; Leighton, J. L. Org. Lett. 2004, 6, 4117-4119. [Link]


35

"Enantioselective Allylation of Ketone-Derived Benzoylhydrazones: Practical Synthesis of Tertiary Carbinamines" Berger, R.; Duff, K; Leighton, J. L. J. Am. Chem. Soc. 2004, 126, 5686-5687. [Link]


34

"An Approach to the Synthesis of Dolabelides A and B: Fragment Synthesis by Tandem Silylformylation-Crotylsilylation" Schmidt, D. R.; Park, P. K.; Leighton, J. L. Org. Lett. 2003, 5, 3535-3537. [Link]


33

"Tandem Silylformylation-Allyl(crotyl)silylation: A New Approach to Polyketide Synthesis" Zacuto, M. J.; O' Malley, S. L.; Leighton, J. L. Tetrahedron 2003, 59, 8889-8900. [Link]


32

"Highly Enantioselective Cu-Catalyzed Conjugate Addition of Alkylzinc Reagents to Cyclic Enones at Ambient Temperature" Krauss, I. J.; Leighton, J. L. Org. Lett. 2003, 5, 3201-3203. [Link]


31

"Toward a Versatile Allylation Reagent: Practical, Enantioselective Allylation of Acylhydazones Using Strained Silacycles" Berger, R.; Rabbat, P. M. A.; Leighton, J. L. J. Am. Chem. Soc. 2003, 32, 9596-9597. [Link]


30

"An Approach to the Synthesis of the Phomodrides" Bio, M. M.; Leighton, J. L. J. Org. Chem. 2003, 68, 1693-1700. [Link]


29

"A Highly Enantioselective and Practical Reagent for the Allylation of Aldehydes" Kubota, K.; Leighton, J. L. Angew. Chem. Int. Ed. 2003, 42, 946-948. [Link]


28

"Catalytic Asymmetric Silane Alcoholysis: Practical Access to Chiral Silanes" Schmidt, D.R.; O' Malley, S.L.; Leighton, J.L. J. Am. Chem. Soc. 2003, 125, 1190-1191. [Link]


27

"Strained Silacylces in Organic Synthesis: The Tandem Aldol-Allylation Reaction" Wang, X.; Meng, Q.; Nation, A. J.; Leighton. J. L. J. Am. Chem. Soc. 2002, 124, 10672-10673. [Link]


26

"Strained Silacylces in Organic Synthesis: A New Reagent for the Enantioselective Allylation of Aldehydes" Kinnaird, J. W. A.; Ng, P. Y.; Kubota, K.; Leighton, J. L. J. Am. Chem. Soc. 2002, 124, 7920-2921. [Link]


25

"Tandem Intramolecular Silylformylation-Crotosilylation: Highly Efficient Synthesis of Polyketide Fragments" Zacuto, M. J.; O'Malley, S. J.; Leighton, J. L. J. Am. Chem. Soc. 2002, 124, 7890-7891. [Link]


24

"Highly Regioselective and Diastereoselective Directed Hydroformylation of Allylic Ethers: A New Approach to Propionate Aldol Synthesis" Krauss, I. J.; Wang, C. C.-Y.; Leighton, J. L. J. Am. Chem. Soc. 2001, 123, 11514-11515. [Link]


23

"Tandem Intramolecular Alkyne Silylformylation-Allylsilylation: A Case of Remote 1,5-Asymmetric Induction" O'Malley, S. J.; Leighton, J. L. Angew. Chem. Int. Ed. Engl. 2001, 40, 2915-2917. [PDF file]


22

"Formal Total Synthesis of Mycoticin A" Dreher, S. D.; Leighton, J. L. J. Am. Chem. Soc. 2001, 123, 341-342. [Link]


21

"Total Synthesis of Leucascandrolide A" Hornberger, K. R.; Hamblett, C. L.; Leighton, J. L. J. Am. Chem. Soc. 2000, 122, 12894-12895. [Link]


20

"Rhodium-Catalyzed Formylation of Organomercurials: Application to Efficient Polyol Synthesis" Sarraf, S.T.; Leighton, J.L. Org. Lett. 2000, 2, 3205-3208. [Link]


19

"Yb(OTf)3-Catalyzed Oxymercuration of Homoallylic Alcohol-Derived Hemiacetals and Hemiketals" Dreher, S. D.; Hornberger, K. R.; Sarraf, S. T.; Leighton, J. L. Org. Lett. 2000, 2, 3197-3199. [Link]


18

"Tandem Intramolecular Silylformylation-Allylsilylation" Zacuto, M.J.; Leighton, J.L. J. Am. Chem. Soc. 2000, 122, 8587-8588. [Link]


17

"Stereoconvergent Palladium-Catalyzed Carbonylation of both E and Z Isomers of a 2-Trifloxy-1,3-Butadiene" Bio, M. M.; Leighton, J. L. Org. Lett. 2000, 2, 2905-2907. [Link]


16

"Oxymercuration of Homoallylic Alcohol-Derived Hemiacetals: Diastereoselective Synthesis of Protected 1,3-Diols" Sarraf, S.T.; Leighton, J.L. Org. Lett., 2000, 2, 403-405. [Link]


15

"An Approach to the Synthesis of CP-263,114: A Remarkably Facile Silyloxy-Cope Rearrangement" Bio, M. M.; Leighton, J. L. J. Am. Chem. Soc., 1999, 121, 890-891. [Link]


14

"Unusual Conformational Effects on the Regioselectivity of Olefin Insertion in the Rhodium-Catalyzed Hydroformylation of 4-Methylene-1,3-Dioxanes" Sarraf, S.T.; Leighton, J.L. Tetrahedron Lett., 1998, 39, 6423-6426. [Link]


13

"Rhodium-Catalyzed Intramolecular Silylformylation of Alkenes" Leighton, J.L.; Chapman, E. J. Am. Chem. Soc. , 1997, 119, 12416-12417. [Link]


12

"Highly Diastereoselective Rhodium-Catalyzed Hydroformylation of Enol Ethers: A Carbonylation-Based Approach to Catalytic Aldol Synthesis" Leighton, J. L.; O'Neil, D. N. J. Am. Chem. Soc., 1997, 119, 11118-11119. [Link]


11

"On the Mechanism of Asymmetric Nucleophilic Ring-Opening of Epoxides Catalyzed by (Salen)Cr(III) Complexes" Hansen, K. B.; Leighton, J. L.; Jacobsen, E. N. J. Am. Chem. Soc., 1996, 118, 10924-10925. [Link]


10

"Efficient Synthesis of (R)-4-((Trimethylsilyl)oxy)-2-cyclopentenone by Enantioselective Catalytic Epoxide Ring Opening" Leighton, J. L.; Jacobsen, E. N. J. Org. Chem., 1996, 61, 389-390. [Link]


9

"Highly Enantioselective Ring Opening of Epoxides Catalyzed by (salen)Cr(III)Complexes" Martínez, L. E.; Leighton, J. L.; Carsten, D. H.; Jacobsen, E. N. J. Am. Chem. Soc., 1995, 117, 5897-5898. [PDF file]


8

"Asymmetric Synthesis of the Squalene Synthase Inhibitor Zaragozic Acid C" Evans, D. A.; Barrow, J. C.; Leighton, J. L.; Robichaud, A. J.; Sefkow, M. J. Am. Chem. Soc., 1994, 116, 12111-12112. [PDF file]


7

"Development of 1,4-Benzodiazepine Cholecystokinin Type B Antagonists" Bock, M.G.; DiPardo, R.M.; Evans, B.E.; Rittle, K.E.; Whitter, W.L.; Garsky, V.M.; Gilbert, K.F.; Leighton, J.L.; Carson, K.L.; Mellin, E.C.; Veber, D.F.; Chang, R.S.L.; Lotti, V.J.; Freedman, S.B.; Smith, A.J.; Patel, S.; Anderson, P.S.; Freidinger, R.M. J. Med. Chem. 1993, 36, 4276-4292. [PDF file]


6

"Nanomolar Affinity, Nonpeptide Oxytocin Receptor Antagonists" Evans, B.E.; Lundell, G.F.; Gilbert, K.F.; Bock, M.G.; Rittle, K.E.; Carroll, L.A.; Williams, P.D.; Pawluczyk, J.M.; Leighton, J.L.; Young, M.B.; Erb, J.M.; Hobbs, D.W.; Gould, N.P.; DiPardo, R.M.; Hoffman, J.B.; Perlow, D.S.; Whitter, W.L.; Veber, D.F.; Pettibone, D.J.; Clineschmidt, B.V.; Anderson, P.S.; Freidinger, R.M. J. Med. Chem. 1993, 36, 3993-4005. [PDF file]


5

"The Asymmetric Synthesis of (+)-Calyculin A, a Nanomolar Phosphatase 1 and 2A Inhibitor" Evans, D.A.; Leighton, J.L.; Gage, J.R. in "Recent Advances in the Chemistry of Anti-infective Agents," Bentley, P.H. and Ponsford, R. Ed.s, Royal Society of Chemistry, 1993, 117-134.


4

"Total Synthesis of (+)-Calyculin A" Evans, D.A.; Gage, J.R.; Leighton, J.L. J. Am. Chem. Soc., 1992, 114, 9434-9453. [PDF file]


3

"Asymmetric Synthesis of Calyculin A. 3. Assemblage of the Calyculin Skeleton and the Introduction of a New Phosphate Monoester Synthesis" Evans, D.A.; Gage, J.R.; Leighton, J.L. J. Org. Chem. 1992, 57, 1964-1966. [PDF file]


2

"Asymmetric Synthesis of Calyculin A. 2. The C26-C37 g-amino acid Fragments" Evans, D.A.; Gage, J.R.; Leighton, J. L.; Kim, A.S. J. Org. Chem. 1992, 57, 1961-1963. [PDF file]


1

"Orally Active, Nonpeptide Oxytocin Antagonists" Evans, B.E.; Leighton, J.L.; Rittle, K.E.; Gilbert, K.F.; Lundell, G.F.; Gould, N.P.; Hobbs, D.W.; DiPardo, R.M.; Veber, D.F.; Pettibone, D.J.; Clineschmidt, B.V.; Anderson, P.S.; Freidinger, R.M. J. Med. Chem. 1992, 35, 3919-3927. [PDF file ]



Maintained by Steven Schwartz | Last Updated: 11 May 2013