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Automated Robotically-based High-throughput Radiation Biodosimetry Active Personnel:
This project is an ongoing collaboration between RARAF and the Mechanical Engineering Departmet (ARMA and MRL) on an NIH funded project (Principal Investigator David Brenner) . Our goal is to develop a fully automated ultra-high throughput radiation biodosimetry workstation, using purpose-built robotics with customized gripper and advanced automatic high-speed liquid handling system. This workstaion is desired to be able to test a large scale radiological exposure on the order of 30,000 individuals per day. Figure 1: An Overview of the High Throughput Workstation A key facet of the system will be that each individual¡¯s whole blood sample will be split into two, with one of the two split samples being irradiated to a dose of 1.8 Gy, before being analyzed. Two lymphocyte samples for the same person will be taken from the whole blood by centrifugation. This will allow a positive control for each individual, providing an internal calibration to take into account inter-individual variability in radiosensitivity. Our Specific Aims, which will run in parallel throughout the project, are Figure 2 shows a working prototype of our Phase I system. This system is capable of handeling 6000 samples/day without human intervention.
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