Welcome to the Sims Lab at Columbia University!

Department of Systems Biology

Department of Biochemistry and Molecular Biophysics

Our group develops new tools for single cell and cell type-specific analysis, focusing mainly on transcriptional and translational regulation.  We apply cutting-edge microscopy, next-generation sequencing, and microfabrication to enable unbiased, genome-wide measurements in heterogeneous biological systems.

We are located on the 2nd floor of the Lasker Biomedical Research Building at Columbia University Medical Center in New York City.

Latest News:

05/22/2019 - Our work on synaptosome flow cytometry is published in eNeuro.

02/21/2019 - Our work on translational regulation in Fragile X Syndrome is in press at Cell Reports. For a preview, see our pre-print on bioRxiv.

01/21/2019 - Our work with David Blei on a powerful new tool for extracting gene signatures from single-cell RNA-seq data is in press at Molecular Systems Biology. For a preview, see our pre-print on bioRxiv.

01/04/2019 - The Sims Lab wins one of eight inaugural Emerging Leader Awards from the Mark Foundation to advance the application of single cell genomics in cancer.