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Dr. Allan Drummond Assistant Professor Department of Biochemistry & Molecular Biology Department of Human Genetics University of Chicago Title: “You err what you eat? Evidence that a nutrient alters translational fidelity and genome-wide protein encoding" Host: Dr. Guy Sella Abstract: We have discovered a large-scale reversal in the relative translational accuracy of codons across twelve fly species. Because the reversal involves pairs of codons which are read by the same genomically encoded tRNAs, we hypothesize, and show experimentally, that a tRNA anticodon modification—from guanosine to queuosine—has coevolved with these genomic changes. This modification is present in most organisms but its function remains unclear. Levels of queuosine modification in flies reflect bioavailability of the precursor nutrient queuine, which eukaryotes scavenge from the tRNAs of bacteria. These results reveal a strikingly direct link between nutrient intake, translational fidelity, and genome-wide exon recoding. |
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