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DR. ANNE BERTOLOTTI Neurobiology Division MRC Laboratory of Molecular Biology Cambridge, UK. Title: Protein Misfolding: Initiation, Propagation and Potential Cure. Implications for Neurodegenerative Diseases. Abstract
The deposition of misfolded proteins is a defining feature of many age-dependent human diseases, including the increasingly prevalent neurodegenerative diseases. Why aggregation-prone proteins accumulate in aged cells remains largely unclear. In fact, cells normally strive to ensure that proteins get correctly folded and indeed all cells have powerful and sophisticated protein quality control systems that very efficiently handle potentially harmful proteins for decades. However, the protein quality control mechanisms seem to gradually fail with age, leading to the accumulation of misfolded proteins with the resulting catastrophic consequences for cells and organisms. I will discuss our recent progress towards understanding the mechanisms that govern the deposition of misfolding-prone proteins, how they propagate in a manner reminiscent of prions and the strategies we have uncovered that reduce the burden of misfolded proteins in cells. Host: Dr. Liz Miller |
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