|Departmental Seminar: Dr. Hartmut Land
|Event Date: 11.25.2013
Time: 12:00 pm
Location: 700 Fairchild
Event Type: Departmental
DR. HARTMUT LAND
Department of Biomedical Genetics and
James P. Wilmot Cancer Center
University of Rochester Medical Center
Title: "Landscape of Cancer Cell Vulnerabilities Downstream of Oncogenic Mutations"
Carcinogenesis is a process driven by multiple co-operating
oncogenic mutations in which features of the cancer cell phenotype, such as
proliferative advantage, only emerge as a result of the interplay between these
mutations. This is consistent with the notion that many divergent cancers share
a limited number of disease mechanisms with common underlying signaling
networks, despite the many genes implicated in the disease. The Land
laboratory has pioneered investigation of the nature and underlying principles
of cancer gene cooperation originating with the discovery that multiple
oncogenic mutations are required for malignant cell transformation. Using a
wide variety of experimental approaches, the laboratory has demonstrated that
the cooperation of cancer-promoting genetic lesions is strongly reflected by
synergistic modulation in signaling and the gene networks of malignant cells.
The lab has identified molecular events downstream of cooperating oncogenic
mutations that are critical to cell transformation. Using genomic approaches,
approximately 100 genes that alter their expression synergistically in response
to the combined effect of two oncogenic mutations were identified. Importantly,
the regulation of these ‘cooperation response genes' (CRG) is critical for the
cancer phenotype at surprisingly high frequency, indicating that oncogenic
mutations cooperate through synergistic regulation of downstream gene networks.
CRGs control diverse cellular processes, including cell signaling, motility,
survival and cell metabolism etc., thus indicating how cooperating oncogenic
mutations ultimately affect multiple parallel cancer cell traits.
Host: Dr. Ron Prywes