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| POST DOCTORAL BIOGRAPHY |
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| Thomas Iskratsch |
| Postdoctoral Fellow |
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| The aim of my research is to understand how cells assemble a force sensing machinery to probe the local microenvironment. Testing of the mechanical properties influences amongst others cell morphology, differentiation or cell migration. The machinery is based on actomyosin arrays, which are connected to the substrate via surface receptors. Since actin is an integral part of this machinery, I investigate which proteins guide the assembly of the actin filaments that are formed from the surface receptors in the context of early cell spreading and during the initial steps of muscle differentiation. For my work I combine cell biology and biophysics with nanotechnological tools to measure or apply forces onto cells, to produce substrates with defined pattern and/or rigidities and to analyse protein localization with highest spatial and temporal resolution. |
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